U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rnps1 RNA binding protein with serine rich domain 1 [ Mus musculus (house mouse) ]

Gene ID: 19826, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rnps1provided by MGI
Official Full Name
RNA binding protein with serine rich domain 1provided by MGI
Primary source
MGI:MGI:97960
See related
Ensembl:ENSMUSG00000034681 AllianceGenome:MGI:97960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable mRNA 3'-UTR binding activity. Predicted to be involved in mRNA metabolic process; positive regulation of apoptotic process; and regulation of mRNA splicing, via spliceosome. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in nucleus. Predicted to be part of ASAP complex. Predicted to be active in cytoplasm and nucleoplasm. Is expressed in central nervous system; sensory organ; thymus; and tooth. Orthologous to human RNPS1 (RNA binding protein with serine rich domain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 88.5), CNS E14 (RPKM 86.1) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rnps1 in Genome Data Viewer
Location:
17 A3.3; 17 12.39 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (24633620..24644872)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (24414646..24425898)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ATP-binding cassette, sub-family A member 3 Neighboring gene predicted gene, 25618 Neighboring gene STARR-seq mESC enhancer starr_42084 Neighboring gene RIKEN cDNA D330041H03 gene Neighboring gene STARR-positive B cell enhancer ABC_E3188 Neighboring gene enoyl-Coenzyme A delta isomerase 1 Neighboring gene deoxyribonuclease 1-like 2

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice. Zhong X, et al. Proc Natl Acad Sci U S A, 2022 May 3. PMID 35482923, Free PMC Article
  2. RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death. Zhang Z, et al. Biochem Biophys Res Commun, 2020 Feb 26. PMID 31831174
  3. Cell type-specific expression of hnRNP proteins. Kamma H, et al. Exp Cell Res, 1995 Nov. PMID 7589244
  4. Sequence of a complete murine cDNA reflecting an S phase-prevalent transcript encoding a protein with two types of nucleic acid binding motifs. Schmidt G, et al. Biochim Biophys Acta, 1993 Nov 16. PMID 8241277
  5. Exon Junction Complex Shapes the Transcriptome by Repressing Recursive Splicing. Blazquez L, et al. Mol Cell, 2018 Nov 1. PMID 30388411, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
    Title: RNPS1 inhibits excessive tumor necrosis factor/tumor necrosis factor receptor signaling to support hematopoiesis in mice.
  2. RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death.
    Title: RNPS1 inhibition aggravates ischemic brain injury and promotes neuronal death.
Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of ASAP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ASAP complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RNA-binding protein with serine-rich domain 1
Names
ribonucleic acid binding protein S1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080127.1 → NP_001073596.1  RNA-binding protein with serine-rich domain 1 isoform 1

    See identical proteins and their annotated locations for NP_001073596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal exon in the 5' UTR, compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AK151150, BX526195, CJ058744
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Related
    ENSMUSP00000085867.6, ENSMUST00000088512.13
    Conserved Domains (1) summary
    cd12365
    Location:163 → 236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

  2. NM_001080128.1 → NP_001073597.1  RNA-binding protein with serine-rich domain 1 isoform 2

    See identical proteins and their annotated locations for NP_001073597.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' region, which results in an alternate translation start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK165905, BX526195, BY013195
    Consensus CDS
    CCDS37487.1
    UniProtKB/Swiss-Prot
    Q99M28
    Related
    ENSMUSP00000111028.2, ENSMUST00000115371.9
    Conserved Domains (1) summary
    cd12365
    Location:140 → 213
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

  3. NM_001357626.1 → NP_001344555.1  RNA-binding protein with serine-rich domain 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AC154237, BQ174147
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Conserved Domains (1) summary
    cd12365
    Location:163 → 236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

  4. NM_009070.2 → NP_033096.2  RNA-binding protein with serine-rich domain 1 isoform 1

    See identical proteins and their annotated locations for NP_033096.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2 and 4 encode the same isoform (1).
    Source sequence(s)
    AK151150, BB868062, BX526195
    Consensus CDS
    CCDS37488.1
    UniProtKB/Swiss-Prot
    Q3TMJ1, Q922H8, Q99M28
    Related
    ENSMUSP00000126345.2, ENSMUST00000163717.2
    Conserved Domains (1) summary
    cd12365
    Location:163 → 236
    RRM_RNPS1; RNA recognition motif (RRM) found in RNA-binding protein with serine-rich domain 1 (RNPS1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    24633620..24644872
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99M28.1 GenPept UniProtKB/Swiss-Prot:Q99M28

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous