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Trim10 tripartite motif-containing 10 [ Mus musculus (house mouse) ]

Gene ID: 19824, updated on 5-Mar-2024

Summary

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Official Symbol
Trim10provided by MGI
Official Full Name
tripartite motif-containing 10provided by MGI
Primary source
MGI:MGI:1338757
See related
Ensembl:ENSMUSG00000073400 AllianceGenome:MGI:1338757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnf9; Herf1
Summary
Predicted to enable ubiquitin protein ligase activity. Involved in innate immune response and negative regulation of viral entry into host cell. Acts upstream of or within erythrocyte differentiation. Located in cytoplasm. Is expressed in bone marrow; embryo; liver; spleen; and ureter. Orthologous to human TRIM10 (tripartite motif containing 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E14 (RPKM 70.7), liver E14.5 (RPKM 69.9) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 19.16 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (37180388..37188725)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (36869496..36877833)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene tripartite motif-containing 26 Neighboring gene predicted gene, 25973 Neighboring gene tripartite motif-containing 15 Neighboring gene phosphatidylethanolamine binding protein 1 pseudogene Neighboring gene tripartite motif-containing 40

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway. Yang H, et al. J Cell Mol Med, 2020 Jun. PMID 32343488, Free PMC Article
  2. Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival. Blaybel R, et al. Cell Res, 2008 Aug. PMID 18560381
  3. Species-specific class I gene expansions formed the telomeric 1 mb of the mouse major histocompatibility complex. Takada T, et al. Genome Res, 2003 Apr. PMID 12671000, Free PMC Article
  4. HERF1, a novel hematopoiesis-specific RING finger protein, is required for terminal differentiation of erythroid cells. Harada H, et al. Mol Cell Biol, 1999 May. PMID 10207104, Free PMC Article
  5. TRIM E3 ligases interfere with early and late stages of the retroviral life cycle. Uchil PD, et al. PLoS Pathog, 2008 Feb 8. PMID 18248090, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
    Title: The ubiquitin E3 ligase TRIM10 promotes STING aggregation and activation in the Golgi apparatus.
  2. Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway.
    Title: Tripartite motif 10 regulates cardiac hypertrophy by targeting the PTEN/AKT pathway.
  3. Primary Spi-1/PU.1 downregulation acts on late erythroid differentiation through at least two pathways, one of which requires TRIM10/HERF1 upregulation and parallels the Spi-1/PU.1-induced Fli-1 shutoff regulatory cascade.
    Title: Downregulation of the Spi-1/PU.1 oncogene induces the expression of TRIM10/HERF1, a key factor required for terminal erythroid cell differentiation and survival.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within erythrocyte differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of viral entry into host cell IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tripartite motif-containing protein 10
Names
hematopoietic RING finger 1
ring finger protein 9
tripartite motif protein 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424810.1 → NP_001411739.1  tripartite motif-containing protein 10 isoform 1

    Status: VALIDATED

    Source sequence(s)
    CR956641

  2. NM_011280.2 → NP_035410.2  tripartite motif-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_035410.2

    Status: VALIDATED

    Source sequence(s)
    AI324236, AK011082, BY712181
    Consensus CDS
    CCDS37614.1
    UniProtKB/Swiss-Prot
    Q80WA9, Q9CY03, Q9WUH5
    Related
    ENSMUSP00000057928.10, ENSMUST00000060524.11
    Conserved Domains (3) summary
    cd00021
    Location:97 → 135
    BBOX; B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction.
    pfam15227
    Location:16 → 60
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15827
    Location:309 → 480
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    37180388..37188725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317359.1 → XP_017172848.1  tripartite motif-containing protein 10 isoform X1

    Conserved Domains (3) summary
    cd15827
    Location:324 → 495
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cd16593
    Location:13 → 61
    RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
    cl00034
    Location:99 → 135
    Bbox_SF; B-box-type zinc finger superfamily

  2. XM_017317361.1 → XP_017172850.1  tripartite motif-containing protein 10 isoform X3

    Conserved Domains (3) summary
    cd15827
    Location:316 → 487
    SPRY_PRY_TRIM10; PRY/SPRY domain of tripartite motif-binding protein 10 (TRIM10) also known as hematopoietic RING finger 1 (HERF1)
    cd16593
    Location:13 → 61
    RING-HC_TRIM10_C-IV; RING finger, HC subclass, found in tripartite motif-containing protein 10 (TRIM10) and similar proteins
    cl00034
    Location:99 → 135
    Bbox_SF; B-box-type zinc finger superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WUH5.2 GenPept UniProtKB/Swiss-Prot:Q9WUH5

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