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WDR90 WD repeat domain 90 [ Homo sapiens (human) ]

Gene ID: 197335, updated on 5-Mar-2024

Summary

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Official Symbol
WDR90provided by HGNC
Official Full Name
WD repeat domain 90provided by HGNC
Primary source
HGNC:HGNC:26960
See related
Ensembl:ENSG00000161996 MIM:618290; AllianceGenome:HGNC:26960
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
POC16; C16orf15; C16orf16; C16orf17; C16orf18; C16orf19
Summary
Involved in cilium assembly. Located in centriole. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 12.0), bone marrow (RPKM 4.3) and 23 other tissues See more
Orthologs
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Genomic context

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See WDR90 in Genome Data Viewer
Location:
16p13.3
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (648979..667830)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (653047..671905)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (699365..717830)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100287175 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:687335-688109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:690840-691751 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6931 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6932 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10209 Neighboring gene MAPK regulated corepressor interacting protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10210 Neighboring gene uncharacterized LOC105371038 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:699402-700224 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:709386-710276 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:717843-718524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6937 Neighboring gene ras homolog family member T2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:724963-725497 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6938 Neighboring gene rhomboid like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity. Steib E, et al. Elife, 2020 Sep 18. PMID 32946374, Free PMC Article
  2. Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis. Hamel V, et al. Curr Biol, 2017 Aug 21. PMID 28781053, Free PMC Article
  3. WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance. Valera-Pérez A, et al. Dev Comp Immunol, 2019 Nov. PMID 31276698
  4. Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. Chen Z, et al. Hum Mol Genet, 2013 Jun 15. PMID 23446634, Free PMC Article
  5. Novel Cul3 binding proteins function to remodel E3 ligase complexes. Wimuttisuk W, et al. BMC Cell Biol, 2014 Jul 10. PMID 25011449, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
    Title: WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.
  2. Study describes WD repeat containing protein 90 (WDR90) as a new inflammasome component. Reconstitution experiments of the human inflammasome in HEK293cells demonstrated that WDR90 was able to physically interact with and to alter the cellular distribution of NLRC4, but not of NLRP3 and AIM2.
    Title: WDR90 is a new component of the NLRC4 inflammasome involved in Salmonella Typhimurium resistance.
  3. This study identified POB15 and POC16 as two proteins of the central core region, the distribution of which correlates with that of tubulin glutamylation; POB15 is an inner barrel protein within this region. Two poc16 mutants exhibit flagellar defects, indicating that POC16 is important for flagellum biogenesis. Human WDR90 is required for ciliogenesis, echoing the findings in Chlamydomonas.
    Title: Identification of Chlamydomonas Central Core Centriolar Proteins Reveals a Role for Human WDR90 in Ciliogenesis.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ36483, FLJ44660, KIAA1924

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 90

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145294.5 → NP_660337.3  WD repeat-containing protein 90

    See identical proteins and their annotated locations for NP_660337.3

    Status: VALIDATED

    Source sequence(s)
    AB067511, AK091062, AK092719, AK126622, Z92544
    Consensus CDS
    CCDS42092.1
    UniProtKB/Swiss-Prot
    Q0VA87, Q0VA88, Q6P048, Q6ZMS1, Q6ZTH1, Q8N202, Q8N221, Q8NBB8, Q96KV7, Q96PW4, Q96S18
    Related
    ENSP00000293879.4, ENST00000293879.9
    Conserved Domains (4) summary
    COG2319
    Location:1155 → 1549
    WD40; WD40 repeat [General function prediction only]
    pfam05018
    Location:5 → 181
    DUF667; Protein of unknown function (DUF667)
    sd00039
    Location:1392 → 1433
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:697 → 991
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    648979..667830
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433744.1 → XP_047289700.1  WD repeat-containing protein 90 isoform X24

  2. XM_047433722.1 → XP_047289678.1  WD repeat-containing protein 90 isoform X1

  3. XM_047433734.1 → XP_047289690.1  WD repeat-containing protein 90 isoform X14

  4. XM_047433724.1 → XP_047289680.1  WD repeat-containing protein 90 isoform X3

  5. XM_047433735.1 → XP_047289691.1  WD repeat-containing protein 90 isoform X15

  6. XM_047433758.1 → XP_047289714.1  WD repeat-containing protein 90 isoform X38

  7. XM_047433747.1 → XP_047289703.1  WD repeat-containing protein 90 isoform X27

  8. XM_047433749.1 → XP_047289705.1  WD repeat-containing protein 90 isoform X29

  9. XM_047433725.1 → XP_047289681.1  WD repeat-containing protein 90 isoform X4

  10. XM_047433738.1 → XP_047289694.1  WD repeat-containing protein 90 isoform X18

  11. XM_047433760.1 → XP_047289716.1  WD repeat-containing protein 90 isoform X40

  12. XM_047433740.1 → XP_047289696.1  WD repeat-containing protein 90 isoform X20

  13. XM_047433730.1 → XP_047289686.1  WD repeat-containing protein 90 isoform X10

  14. XM_047433750.1 → XP_047289706.1  WD repeat-containing protein 90 isoform X30

  15. XM_047433753.1 → XP_047289709.1  WD repeat-containing protein 90 isoform X33

  16. XM_047433723.1 → XP_047289679.1  WD repeat-containing protein 90 isoform X2

  17. XM_047433736.1 → XP_047289692.1  WD repeat-containing protein 90 isoform X16

  18. XM_047433751.1 → XP_047289707.1  WD repeat-containing protein 90 isoform X31

  19. XM_047433726.1 → XP_047289682.1  WD repeat-containing protein 90 isoform X5

  20. XM_047433739.1 → XP_047289695.1  WD repeat-containing protein 90 isoform X19

  21. XM_047433741.1 → XP_047289697.1  WD repeat-containing protein 90 isoform X21

  22. XM_047433731.1 → XP_047289687.1  WD repeat-containing protein 90 isoform X11

  23. XM_047433752.1 → XP_047289708.1  WD repeat-containing protein 90 isoform X32

  24. XM_047433733.1 → XP_047289689.1  WD repeat-containing protein 90 isoform X13

  25. XM_047433757.1 → XP_047289713.1  WD repeat-containing protein 90 isoform X37

  26. XM_047433759.1 → XP_047289715.1  WD repeat-containing protein 90 isoform X39

  27. XM_047433742.1 → XP_047289698.1  WD repeat-containing protein 90 isoform X22

  28. XM_047433763.1 → XP_047289719.1  WD repeat-containing protein 90 isoform X43

  29. XM_017023023.2 → XP_016878512.1  WD repeat-containing protein 90 isoform X6

  30. XM_047433743.1 → XP_047289699.1  WD repeat-containing protein 90 isoform X23

  31. XM_047433754.1 → XP_047289710.1  WD repeat-containing protein 90 isoform X34

  32. XM_047433728.1 → XP_047289684.1  WD repeat-containing protein 90 isoform X8

  33. XM_047433745.1 → XP_047289701.1  WD repeat-containing protein 90 isoform X25

  34. XM_047433764.1 → XP_047289720.1  WD repeat-containing protein 90 isoform X44

  35. XM_047433748.1 → XP_047289704.1  WD repeat-containing protein 90 isoform X28

  36. XM_047433732.1 → XP_047289688.1  WD repeat-containing protein 90 isoform X12

  37. XM_047433756.1 → XP_047289712.1  WD repeat-containing protein 90 isoform X36

  38. XM_047433727.1 → XP_047289683.1  WD repeat-containing protein 90 isoform X7

  39. XM_047433729.1 → XP_047289685.1  WD repeat-containing protein 90 isoform X9

  40. XM_047433746.1 → XP_047289702.1  WD repeat-containing protein 90 isoform X26

    UniProtKB/TrEMBL
    F8VUX9
    Related
    ENSP00000448122.1, ENST00000549091.5

  41. XM_047433765.1 → XP_047289721.1  WD repeat-containing protein 90 isoform X45

  42. XM_047433755.1 → XP_047289711.1  WD repeat-containing protein 90 isoform X35

  43. XM_047433761.1 → XP_047289717.1  WD repeat-containing protein 90 isoform X41

  44. XM_047433737.1 → XP_047289693.1  WD repeat-containing protein 90 isoform X17

  45. XM_047433762.1 → XP_047289718.1  WD repeat-containing protein 90 isoform X42

  46. XM_047433766.1 → XP_047289722.1  WD repeat-containing protein 90 isoform X46

  47. XM_047433767.1 → XP_047289723.1  WD repeat-containing protein 90 isoform X47

  48. XM_047433768.1 → XP_047289724.1  WD repeat-containing protein 90 isoform X48

  49. XM_017023024.2 → XP_016878513.1  WD repeat-containing protein 90 isoform X49

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    653047..671905
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054379776.1 → XP_054235751.1  WD repeat-containing protein 90 isoform X24

  2. XM_054379753.1 → XP_054235728.1  WD repeat-containing protein 90 isoform X1

  3. XM_054379766.1 → XP_054235741.1  WD repeat-containing protein 90 isoform X14

  4. XM_054379755.1 → XP_054235730.1  WD repeat-containing protein 90 isoform X3

  5. XM_054379767.1 → XP_054235742.1  WD repeat-containing protein 90 isoform X15

  6. XM_054379790.1 → XP_054235765.1  WD repeat-containing protein 90 isoform X38

  7. XM_054379779.1 → XP_054235754.1  WD repeat-containing protein 90 isoform X27

  8. XM_054379781.1 → XP_054235756.1  WD repeat-containing protein 90 isoform X29

  9. XM_054379756.1 → XP_054235731.1  WD repeat-containing protein 90 isoform X4

  10. XM_054379770.1 → XP_054235745.1  WD repeat-containing protein 90 isoform X18

  11. XM_054379792.1 → XP_054235767.1  WD repeat-containing protein 90 isoform X40

  12. XM_054379772.1 → XP_054235747.1  WD repeat-containing protein 90 isoform X20

  13. XM_054379762.1 → XP_054235737.1  WD repeat-containing protein 90 isoform X10

  14. XM_054379782.1 → XP_054235757.1  WD repeat-containing protein 90 isoform X30

  15. XM_054379785.1 → XP_054235760.1  WD repeat-containing protein 90 isoform X33

  16. XM_054379754.1 → XP_054235729.1  WD repeat-containing protein 90 isoform X2

  17. XM_054379768.1 → XP_054235743.1  WD repeat-containing protein 90 isoform X16

  18. XM_054379783.1 → XP_054235758.1  WD repeat-containing protein 90 isoform X31

  19. XM_054379757.1 → XP_054235732.1  WD repeat-containing protein 90 isoform X5

  20. XM_054379771.1 → XP_054235746.1  WD repeat-containing protein 90 isoform X19

  21. XM_054379773.1 → XP_054235748.1  WD repeat-containing protein 90 isoform X21

  22. XM_054379763.1 → XP_054235738.1  WD repeat-containing protein 90 isoform X11

  23. XM_054379784.1 → XP_054235759.1  WD repeat-containing protein 90 isoform X32

  24. XM_054379765.1 → XP_054235740.1  WD repeat-containing protein 90 isoform X13

  25. XM_054379789.1 → XP_054235764.1  WD repeat-containing protein 90 isoform X37

  26. XM_054379791.1 → XP_054235766.1  WD repeat-containing protein 90 isoform X39

  27. XM_054379774.1 → XP_054235749.1  WD repeat-containing protein 90 isoform X22

  28. XM_054379795.1 → XP_054235770.1  WD repeat-containing protein 90 isoform X43

  29. XM_054379758.1 → XP_054235733.1  WD repeat-containing protein 90 isoform X6

  30. XM_054379775.1 → XP_054235750.1  WD repeat-containing protein 90 isoform X23

  31. XM_054379786.1 → XP_054235761.1  WD repeat-containing protein 90 isoform X34

  32. XM_054379760.1 → XP_054235735.1  WD repeat-containing protein 90 isoform X8

  33. XM_054379777.1 → XP_054235752.1  WD repeat-containing protein 90 isoform X25

  34. XM_054379796.1 → XP_054235771.1  WD repeat-containing protein 90 isoform X44

  35. XM_054379780.1 → XP_054235755.1  WD repeat-containing protein 90 isoform X28

  36. XM_054379764.1 → XP_054235739.1  WD repeat-containing protein 90 isoform X12

  37. XM_054379788.1 → XP_054235763.1  WD repeat-containing protein 90 isoform X36

  38. XM_054379759.1 → XP_054235734.1  WD repeat-containing protein 90 isoform X7

  39. XM_054379761.1 → XP_054235736.1  WD repeat-containing protein 90 isoform X9

  40. XM_054379778.1 → XP_054235753.1  WD repeat-containing protein 90 isoform X26

    UniProtKB/TrEMBL
    F8VUX9

  41. XM_054379797.1 → XP_054235772.1  WD repeat-containing protein 90 isoform X45

  42. XM_054379787.1 → XP_054235762.1  WD repeat-containing protein 90 isoform X35

  43. XM_054379793.1 → XP_054235768.1  WD repeat-containing protein 90 isoform X41

  44. XM_054379769.1 → XP_054235744.1  WD repeat-containing protein 90 isoform X17

  45. XM_054379794.1 → XP_054235769.1  WD repeat-containing protein 90 isoform X42

  46. XM_054379798.1 → XP_054235773.1  WD repeat-containing protein 90 isoform X46

  47. XM_054379799.1 → XP_054235774.1  WD repeat-containing protein 90 isoform X47

  48. XM_054379800.1 → XP_054235775.1  WD repeat-containing protein 90 isoform X48

  49. XM_054379801.1 → XP_054235776.1  WD repeat-containing protein 90 isoform X49

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_153239.2: Suppressed sequence

    Description
    NM_153239.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96KV7.2 GenPept UniProtKB/Swiss-Prot:Q96KV7

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