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Rgl2 ral guanine nucleotide dissociation stimulator-like 2 [ Mus musculus (house mouse) ]

Gene ID: 19732, updated on 3-Apr-2024

Summary

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Official Symbol
Rgl2provided by MGI
Official Full Name
ral guanine nucleotide dissociation stimulator-like 2provided by MGI
Primary source
MGI:MGI:107483
See related
Ensembl:ENSMUSG00000041354 AllianceGenome:MGI:107483
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rlf; Rgt2; KE1.5; Rab2l
Summary
Enables guanyl-nucleotide exchange factor activity. Acts upstream of or within negative regulation of cardiac muscle cell apoptotic process; positive regulation of phosphatidylinositol 3-kinase signaling; and regulation of Ral protein signal transduction. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; integumental system; and nervous system. Orthologous to human RGL2 (ral guanine nucleotide dissociation stimulator like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 47.5), spleen adult (RPKM 34.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 B1; 17 17.98 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34148813..34156661)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33929514..33937687)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 22 Neighboring gene STARR-positive B cell enhancer ABC_E5592 Neighboring gene STARR-positive B cell enhancer ABC_E7521 Neighboring gene predicted gene, 19412 Neighboring gene TAP binding protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene prefoldin subunit 6 Neighboring gene WD repeat domain 46

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation. Popovic M, et al. J Struct Biol, 2013 Sep. PMID 23891840
  2. Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes. Post GR, et al. J Biol Chem, 2002 May 3. PMID 11847222
  3. The ral exchange factor rgl2 promotes cardiomyocyte survival and inhibits cardiac fibrosis. Scotland RL, et al. PLoS One, 2013. PMID 24069211, Free PMC Article
  4. RalGDS-like factor (Rlf) is a novel Ras and Rap 1A-associating protein. Wolthuis RM, et al. Oncogene, 1996 Jul 18. PMID 8710374
  5. Structure determination of the Ras-binding domain of the Ral-specific guanine nucleotide exchange factor Rlf. Esser D, et al. Biochemistry, 1998 Sep 29. PMID 9753431

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The crystal structure of the mouse Rgl2 REM- and a CDC25-homology domain.
    Title: The guanine nucleotide exchange factor Rlf interacts with SH3 domain-containing proteins via a binding site with a preselected conformation.
  2. induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses
    Title: Guanine nucleotide exchange factor-like factor (Rlf) induces gene expression and potentiates alpha 1-adrenergic receptor-induced transcriptional responses in neonatal rat ventricular myocytes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of cardiac muscle cell apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of Ral protein signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ral guanine nucleotide dissociation stimulator-like 2
Names
RalGDS-like factor
ralGDS-like 2
ras-associated protein RAB2L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001410640.1 → NP_001397569.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    CR974462

  2. NM_001410641.1 → NP_001397570.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    CR974462

  3. NM_001410645.1 → NP_001397574.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462

  4. NM_001410646.1 → NP_001397575.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462

  5. NM_001410647.1 → NP_001397576.1  ral guanine nucleotide dissociation stimulator-like 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    CR974462

  6. NM_009059.3 → NP_033085.2  ral guanine nucleotide dissociation stimulator-like 2 isoform 1

    See identical proteins and their annotated locations for NP_033085.2

    Status: VALIDATED

    Source sequence(s)
    CR974462
    Consensus CDS
    CCDS28635.1
    UniProtKB/Swiss-Prot
    Q61193, Q9QUJ2
    UniProtKB/TrEMBL
    A0A068BD34
    Related
    ENSMUSP00000041082.10, ENSMUST00000047503.16
    Conserved Domains (3) summary
    cd00153
    Location:649 → 734
    RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins
    smart00147
    Location:239 → 513
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:90 → 212
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RNA

  1. NR_177102.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462

  2. NR_177103.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462

  3. NR_177105.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    CR974462

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    34148813..34156661
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006523910.2 → XP_006523973.1  ral guanine nucleotide dissociation stimulator-like 2 isoform X1

    See identical proteins and their annotated locations for XP_006523973.1

    UniProtKB/TrEMBL
    A0A068BD34
    Conserved Domains (3) summary
    smart00147
    Location:126 → 400
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
    smart00229
    Location:1 → 99
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd17211
    Location:536 → 621
    RA_RGL2; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator-like 2 (RalGDS-like 2) and similar proteins

RNA

  1. XR_385304.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61193.2 GenPept UniProtKB/Swiss-Prot:Q61193

Gene LinkOut

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