Ralgds ral guanine nucleotide dissociation stimulator [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ralgdsprovided by MGI
Official Full Name: ral guanine nucleotide dissociation stimulatorprovided by MGI
Primary source: MGI:MGI:107485
See related: Ensembl:ENSMUSG00000026821 AllianceGenome:MGI:107485
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gnds; Rgds; mKIAA1308
Summary: Predicted to enable GTPase regulator activity. Predicted to be involved in small GTPase mediated signal transduction. Predicted to act upstream of or within regulation of catalytic activity. Predicted to be located in brush border; cytosol; and nucleus. Is expressed in several structures, including blastocyst; early embryo; nervous system; ovary; and retina. Orthologous to human RALGDS (ral guanine nucleotide dissociation stimulator). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in testis adult (RPKM 54.6), colon adult (RPKM 48.6) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 19.38 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (28403037..28443085)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (28513089..28553082)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

In this paper, we demonstrate a potential biochemical mechanism for such phenomena by showing that c-Met receptors promote the tyrosine phosphorylation of RalGDS at Y752 in its RBD, which blocks the binding of Ras to RalGDS.
Title: Tyrosine phosphorylation of RalGDS by c-Met receptor blocks its interaction with Ras.
Data implicate RalGDS-mediated induction of autophagy and exocyst function as a critical feature of load-induced cardiac hypertrophy.
Title: RalGDS-dependent cardiomyocyte autophagy is required for load-induced ventricular hypertrophy.
constitutive RalGEF activation had a major impact on several malignant phenotypes, particularly anchorage-independent growth, indicating that this often overlooked pathway should be more carefully evaluated as a possible therapeutic target.
Title: Dissection of RAS downstream pathways in melanomagenesis: a role for Ral in transformation.
Results identify RalGDS as a key component in Ras-dependent carcinogenesis in vivo.
Title: RalGDS is required for tumor formation in a model of skin carcinogenesis.
we investigated the activation of RalGDS, one of the Ras effector proteins with guanine-nucleotide exchange factor activity for Ral.
Title: The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTPase regulator activity	ISO Inferred from Sequence Orthology more info
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in small GTPase-mediated signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in brush border	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: ral guanine nucleotide dissociation stimulator

Names: ral guanine nucleotide exchange factor; ralGEF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001145834.2 → NP_001139306.1 ral guanine nucleotide dissociation stimulator isoform 4

See identical proteins and their annotated locations for NP_001139306.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) uses an alternate in-frame splice site at the 5' end of an exon and differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (4) lacks an internal segment and has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL772249

UniProtKB/TrEMBL

Q3TXZ3, Q3UQY9

Conserved Domains (3) summary

cd00153
Location:724 → 809

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

smart00147
Location:308 → 575

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:57 → 181

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001145835.2 → NP_001139307.1 ral guanine nucleotide dissociation stimulator isoform 1

See identical proteins and their annotated locations for NP_001139307.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AL772249

Consensus CDS

CCDS50547.1

UniProtKB/TrEMBL

Q3TWC1, Q3TXZ3

Related

ENSMUSP00000097812.4, ENSMUST00000100241.10

Conserved Domains (3) summary

cd00153
Location:791 → 876

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

smart00147
Location:375 → 642

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 248

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001145836.2 → NP_001139308.1 ral guanine nucleotide dissociation stimulator isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site at the 5' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AL772249

Consensus CDS

CCDS50548.1

UniProtKB/TrEMBL

A2AK33, Q3TXZ3

Related

ENSMUSP00000109526.2, ENSMUST00000113893.8

Conserved Domains (3) summary

cd00153
Location:779 → 864

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

smart00147
Location:363 → 630

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 236

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
NM_001420861.1 → NP_001407790.1 ral guanine nucleotide dissociation stimulator isoform 5

Status: VALIDATED

Source sequence(s)

AL772249
NM_001420862.1 → NP_001407791.1 ral guanine nucleotide dissociation stimulator isoform 6

Status: VALIDATED

Source sequence(s)

AL772249
NM_001420863.1 → NP_001407792.1 ral guanine nucleotide dissociation stimulator isoform 7

Status: VALIDATED

Source sequence(s)

AL772249
NM_001420864.1 → NP_001407793.1 ral guanine nucleotide dissociation stimulator isoform 8

Status: VALIDATED

Source sequence(s)

AL772249
NM_001420865.1 → NP_001407794.1 ral guanine nucleotide dissociation stimulator isoform 9

Status: VALIDATED

Source sequence(s)

AL772249
NM_009058.3 → NP_033084.2 ral guanine nucleotide dissociation stimulator isoform 3

See identical proteins and their annotated locations for NP_033084.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.

Source sequence(s)

AL772249

Consensus CDS

CCDS15840.1

UniProtKB/Swiss-Prot

Q03385, Q8R077

UniProtKB/TrEMBL

Q6ZPU1

Related

ENSMUSP00000028170.9, ENSMUST00000028170.15

Conserved Domains (3) summary

cd00153
Location:736 → 821

RalGDS_RA; Ubiquitin domain of RalGDS-like factor (RLF) and related proteins

smart00147
Location:320 → 587

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:57 → 193

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

RNA

NR_185206.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772249
NR_185207.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AL772249

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

28403037..28443085

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159765.1 → XP_036015658.1 ral guanine nucleotide dissociation stimulator isoform X7

UniProtKB/TrEMBL

Q6ZPU1

Conserved Domains (3) summary

smart00147
Location:320 → 564

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:57 → 193

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd17209
Location:713 → 798

RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
XM_006497797.5 → XP_006497860.1 ral guanine nucleotide dissociation stimulator isoform X4

UniProtKB/TrEMBL

Q3TXZ3

Conserved Domains (3) summary

smart00147
Location:376 → 643

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 249

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd17209
Location:734 → 819

RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
XM_036159759.1 → XP_036015652.1 ral guanine nucleotide dissociation stimulator isoform X2

UniProtKB/TrEMBL

Q3TXZ3

Conserved Domains (3) summary

smart00147
Location:376 → 620

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 249

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd17209
Location:769 → 854

RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
XM_030248854.2 → XP_030104714.1 ral guanine nucleotide dissociation stimulator isoform X5

UniProtKB/TrEMBL

Q3TXZ3

Conserved Domains (3) summary

smart00147
Location:375 → 642

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 248

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd17209
Location:733 → 818

RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins
XM_006497796.4 → XP_006497859.1 ral guanine nucleotide dissociation stimulator isoform X1

UniProtKB/TrEMBL

Q3TXZ3

Conserved Domains (3) summary

smart00147
Location:376 → 643

RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases

smart00229
Location:112 → 249

RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif

cd17209
Location:792 → 877

RA_RalGDS; Ras-associating (RA) domain found in Ral guanine nucleotide dissociation stimulator (RalGDS) and similar proteins