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Rfng RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase [ Mus musculus (house mouse) ]

Gene ID: 19719, updated on 5-Mar-2024

Summary

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Official Symbol
Rfngprovided by MGI
Official Full Name
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferaseprovided by MGI
Primary source
MGI:MGI:894275
See related
Ensembl:ENSMUSG00000025158 AllianceGenome:MGI:894275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity. Involved in regulation of Notch signaling pathway. Acts upstream of or within positive regulation of Notch signaling pathway and positive regulation of protein binding activity. Predicted to be located in Golgi apparatus and membrane. Predicted to be integral component of Golgi membrane. Is expressed in several structures, including central nervous system; genitourinary system; limb; retina; and small intestine. Orthologous to human RFNG (RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 67.3), adrenal adult (RPKM 54.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rfng in Genome Data Viewer
Location:
11 E2; 11 84.53 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (120671571..120675077, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (120780745..120784251, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene high mobility group AT-hook 1B Neighboring gene STARR-seq mESC enhancer starr_31367 Neighboring gene NADPH-dependent carbonyl reductase pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120637476-120637735 Neighboring gene STARR-seq mESC enhancer starr_31368 Neighboring gene G protein pathway suppressor 1 Neighboring gene dihydrouridine synthase 1 like Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:120657732-120657915 Neighboring gene fatty acid synthase Neighboring gene STARR-positive B cell enhancer ABC_E9039

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Limbs move beyond the radical fringe. Moran JL, et al. Nature, 1999 Jun 24. PMID 10391239
  2. Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development. Song Y, et al. J Immunol, 2016 Jan 1. PMID 26608918, Free PMC Article
  3. Lunatic fringe, manic fringe, and radical fringe recognize similar specificity determinants in O-fucosylated epidermal growth factor-like repeats. Rampal R, et al. J Biol Chem, 2005 Dec 23. PMID 16221665
  4. Radical and lunatic fringes modulate notch ligands to support mammalian intestinal homeostasis. Kadur Lakshminarasimha Murthy P, et al. Elife, 2018 Apr 9. PMID 29629872, Free PMC Article
  5. Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype. Ryan MJ, et al. Hepatology, 2008 Dec. PMID 19026002

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fringe modifications at EGF8 and EGF12 enhanced Notch1 binding to and activation from Delta-like 1, while modifications at EGF6 and EGF36 (added by Manic and Lunatic but not Radical) inhibited Notch1 activation from Jagged1.
    Title: Deciphering the Fringe-Mediated Notch Code: Identification of Activating and Inhibiting Sites Allowing Discrimination between Ligands.
  2. each Fringe contributes to T and B cell development, and Fringe is required for optimal in vitro stimulation of T and B cells.
    Title: Lunatic, Manic, and Radical Fringe Each Promote T and B Cell Development.
  3. No obvious synergistic defects in mice in the absence of two, or all three, fringe genes during development of the axial skeleton, limbs, hindbrain, and cranial nerves.
    Title: Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain.
  4. Jag1/fringe genes (Lfng, Rfng, and Mfng) may regulate postnatal bile duct growth and remodeling, and serve as candidate modifiers of the hepatic phenotype in Alagille syndrome.
    Title: Bile duct proliferation in Jag1/fringe heterozygous mice identifies candidate modifiers of the Alagille syndrome hepatic phenotype.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC90122

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in pattern specification process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
beta-1,3-N-acetylglucosaminyltransferase radical fringe
Names
O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
radical fringe gene homolog
NP_033079.1
XP_006532669.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009053.2 → NP_033079.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe

    See identical proteins and their annotated locations for NP_033079.1

    Status: VALIDATED

    Source sequence(s)
    BC066023
    Consensus CDS
    CCDS25757.1
    UniProtKB/Swiss-Prot
    B1ATU3, O09009
    Related
    ENSMUSP00000026156.8, ENSMUST00000026156.8
    Conserved Domains (1) summary
    pfam02434
    Location:56 → 306
    Fringe; Fringe-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    120671571..120675077 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532606.3 → XP_006532669.1  beta-1,3-N-acetylglucosaminyltransferase radical fringe isoform X1

    Conserved Domains (1) summary
    pfam02434
    Location:56 → 249
    Fringe; Fringe-like

RNA

  1. XR_003949362.1 RNA Sequence

  2. XR_001779932.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O09009.1 GenPept UniProtKB/Swiss-Prot:O09009

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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