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Renbp renin binding protein [ Mus musculus (house mouse) ]

Gene ID: 19703, updated on 25-Apr-2024

Summary

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Official Symbol
Renbpprovided by MGI
Official Full Name
renin binding proteinprovided by MGI
Primary source
MGI:MGI:105940
See related
Ensembl:ENSMUSG00000031387 AllianceGenome:MGI:105940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Age; Rnbp
Summary
Enables N-acylglucosamine 2-epimerase activity. Acts upstream of or within N-acetylglucosamine metabolic process. Orthologous to human RENBP (renin binding protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in placenta adult (RPKM 61.2), kidney adult (RPKM 37.8) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A7.3; X 37.49 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (72965727..72974408, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (73922121..73930850, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene Rho GTPase activating protein 4 Neighboring gene arginine vasopressin receptor 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chrX:71157031-71157252 Neighboring gene STARR-seq mESC enhancer starr_47360 Neighboring gene N(alpha)-acetyltransferase 10, NatA catalytic subunit Neighboring gene STARR-seq mESC enhancer starr_47361 Neighboring gene host cell factor C1 Neighboring gene STARR-seq mESC enhancer starr_47362 Neighboring gene STARR-seq mESC enhancer starr_47363 Neighboring gene STARR-seq mESC enhancer starr_47364 Neighboring gene predicted gene 8545

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. Schmitz C, et al. J Biol Chem, 2000 May 19. PMID 10809771
  2. The chromosome localization and the HCF repeats of the human host cell factor gene (HCFC1) are conserved in the mouse homologue. Frattini A, et al. Genomics, 1996 Mar 1. PMID 8833156
  3. Metabolism of vertebrate amino sugars with N-glycolyl groups: elucidating the intracellular fate of the non-human sialic acid N-glycolylneuraminic acid. Bergfeld AK, et al. J Biol Chem, 2012 Aug 17. PMID 22692205, Free PMC Article
  4. Galnt11 regulates kidney function by glycosylating the endocytosis receptor megalin to modulate ligand binding. Tian E, et al. Proc Natl Acad Sci U S A, 2019 Dec 10. PMID 31740596, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Targeted (1)  1 citation

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables N-acylglucosamine 2-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acylglucosamine 2-epimerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables N-acylglucosamine 2-epimerase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables N-acylglucosamine 2-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables enzyme inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables purine nucleotide binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in N-acetylglucosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within N-acetylglucosamine metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in N-acetylglucosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylmannosamine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in N-acetylmannosamine metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in N-acetylneuraminate catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acylglucosamine 2-epimerase
Names
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
NP_001158176.1
NP_001412884.1
NP_001412885.1
NP_001412886.1
NP_001412887.1
NP_001412888.1
NP_075621.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164704.2 → NP_001158176.1  N-acylglucosamine 2-epimerase isoform 2

    See identical proteins and their annotated locations for NP_001158176.1

    Status: VALIDATED

    Description
    Transcript Variant:
    Source sequence(s)
    AL672002
    Consensus CDS
    CCDS57763.1
    UniProtKB/TrEMBL
    A0A8Z1S8W2
    Related
    ENSMUSP00000110020.2, ENSMUST00000114379.8
    Conserved Domains (1) summary
    cd00249
    Location:15 → 394
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

  2. NM_001425955.1 → NP_001412884.1  N-acylglucosamine 2-epimerase isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), encodes the longest isoform (3).
    Source sequence(s)
    AL672002
    UniProtKB/Swiss-Prot
    P82343, Q3TIZ6, Q3UJ23, Q80Z67, Q91WI9, Q9CXI1
    UniProtKB/TrEMBL
    D6RHA2

  3. NM_001425956.1 → NP_001412885.1  N-acylglucosamine 2-epimerase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AL672002

  4. NM_001425957.1 → NP_001412886.1  N-acylglucosamine 2-epimerase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL672002

  5. NM_001425958.1 → NP_001412887.1  N-acylglucosamine 2-epimerase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672002

  6. NM_001425959.1 → NP_001412888.1  N-acylglucosamine 2-epimerase isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL672002

  7. NM_023132.4 → NP_075621.3  N-acylglucosamine 2-epimerase isoform 1

    See identical proteins and their annotated locations for NP_075621.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AL672002
    Consensus CDS
    CCDS41015.2
    UniProtKB/TrEMBL
    A0A8Z1SL50
    Related
    ENSMUSP00000112277.2, ENSMUST00000116578.8
    Conserved Domains (1) summary
    cd00249
    Location:15 → 408
    AGE; AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is ...

RNA

  1. NR_189639.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672002

  2. NR_189640.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL672002

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    72965727..72974408 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P82343.4 GenPept UniProtKB/Swiss-Prot:P82343

Gene LinkOut

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