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Recql RecQ protein-like [ Mus musculus (house mouse) ]

Gene ID: 19691, updated on 18-Apr-2024

Summary

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Official Symbol
Recqlprovided by MGI
Official Full Name
RecQ protein-likeprovided by MGI
Primary source
MGI:MGI:103021
See related
Ensembl:ENSMUSG00000030243 AllianceGenome:MGI:103021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RecQ1
Summary
Predicted to enable 3'-5' DNA helicase activity; ATP-dependent DNA/DNA annealing activity; and four-way junction helicase activity. Predicted to be involved in DNA unwinding involved in DNA replication and double-strand break repair via homologous recombination. Predicted to be located in nucleoplasm. Predicted to be active in chromosome and cytoplasm. Is expressed in cerebral cortex subventricular zone. Human ortholog(s) of this gene implicated in hepatocellular carcinoma; lung cancer; and pancreatic cancer. Orthologous to human RECQL (RecQ like helicase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.8), CNS E14 (RPKM 3.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 G2; 6 73.91 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (142296068..142332802, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (142350342..142387100, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene solute carrier organic anion transporter family, member 1a5 Neighboring gene STARR-seq mESC enhancer starr_17703 Neighboring gene islet amyloid polypeptide Neighboring gene 60S ribosomal protein L18 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6502 Neighboring gene pyridine nucleotide-disulphide oxidoreductase domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1716 Neighboring gene golgi transport 1B Neighboring gene spexin hormone

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability. Sharma S, et al. Mol Cell Biol, 2007 Mar. PMID 17158923, Free PMC Article
  2. Cloning of two isoforms of mouse DNA helicase Q1/RecQL cDNA; alpha form is expressed ubiquitously and beta form specifically in the testis. Wang WS, et al. Biochim Biophys Acta, 1998 Nov 26. PMID 9838113
  3. Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue. Puranam KL, et al. Genomics, 1995 Apr 10. PMID 7607686
  4. RecQ helicases: suppressors of tumorigenesis and premature aging. Bachrati CZ, et al. Biochem J, 2003 Sep 15. PMID 12803543, Free PMC Article
  5. Mapping of six germ-cell-specific genes to mouse chromosomes. Matsui M, et al. Mamm Genome, 1997. PMID 9337410

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Recql suppresses chromosomal instability.
    Title: RECQL, a member of the RecQ family of DNA helicases, suppresses chromosomal instability.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1)  1 citation
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 3'-5' DNA helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3'-5' DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA/DNA annealing activity ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA helicase activity ISO
Inferred from Sequence Orthology
more info
  
enables four-way junction helicase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA recombination IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA unwinding involved in DNA replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in double-strand break repair via homologous recombination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in replication fork processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in chromosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ATP-dependent DNA helicase Q1
Names
DNA-dependent ATPase Q1
recQ protein-like 1
NP_001191835.1
NP_001191836.1
NP_001342440.1
NP_001397234.1
NP_001397235.1
NP_001397236.1
NP_001397237.1
NP_001397238.1
NP_075529.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204906.2 → NP_001191835.1  ATP-dependent DNA helicase Q1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS57466.1
    UniProtKB/TrEMBL
    E9Q3N0, Q3UFL0
    Related
    ENSMUSP00000098394.4, ENSMUST00000100832.10
    Conserved Domains (5) summary
    TIGR00614
    Location:81 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family
    cd00079
    Location:285 → 417
    HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
    pfam00270
    Location:93 → 268
    DEAD; DEAD/DEAH box helicase
    pfam16124
    Location:422 → 478
    RecQ_Zn_bind; RecQ zinc-binding
    cl09632
    Location:484 → 576
    RQC; RQC domain

  2. NM_001204907.2 → NP_001191836.1  ATP-dependent DNA helicase Q1 isoform 3

    See identical proteins and their annotated locations for NP_001191836.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and uses an alternate splice site in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1. Variants 3 and 9 both encode the same isoform (3).
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS57465.1
    UniProtKB/TrEMBL
    Q3UFL0, Q3UUK0
    Related
    ENSMUSP00000032370.7, ENSMUST00000032370.13
    Conserved Domains (1) summary
    TIGR00614
    Location:81 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  3. NM_001355511.2 → NP_001342440.1  ATP-dependent DNA helicase Q1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1 and 4 encode the same protein (isoform 1).
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS39695.1
    UniProtKB/Swiss-Prot
    Q3TPI5, Q9Z128, Q9Z129
    UniProtKB/TrEMBL
    Q91YU1
    Conserved Domains (1) summary
    TIGR00614
    Location:81 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

  4. NM_001410305.1 → NP_001397234.1  ATP-dependent DNA helicase Q1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC102125, AC142413
    UniProtKB/Swiss-Prot
    Q3TPI5, Q9Z128, Q9Z129

  5. NM_001410306.1 → NP_001397235.1  ATP-dependent DNA helicase Q1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC102125, AC142413

  6. NM_001410307.1 → NP_001397236.1  ATP-dependent DNA helicase Q1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102125, AC142413

  7. NM_001410308.1 → NP_001397237.1  ATP-dependent DNA helicase Q1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC102125, AC142413

  8. NM_001410309.1 → NP_001397238.1  ATP-dependent DNA helicase Q1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC102125, AC142413
    UniProtKB/TrEMBL
    Q3UUK0

  9. NM_023042.4 → NP_075529.2  ATP-dependent DNA helicase Q1 isoform 1

    See identical proteins and their annotated locations for NP_075529.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC102125, AC142413
    Consensus CDS
    CCDS39695.1
    UniProtKB/Swiss-Prot
    Q3TPI5, Q9Z128, Q9Z129
    UniProtKB/TrEMBL
    Q91YU1
    Related
    ENSMUSP00000107434.3, ENSMUST00000111803.9
    Conserved Domains (1) summary
    TIGR00614
    Location:81 → 543
    recQ_fam; ATP-dependent DNA helicase, RecQ family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    142296068..142332802 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z129.2 GenPept UniProtKB/Swiss-Prot:Q9Z129

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