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Rfc1 replication factor C (activator 1) 1 [ Mus musculus (house mouse) ]

Gene ID: 19687, updated on 21-Apr-2024

Summary

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Official Symbol
Rfc1provided by MGI
Official Full Name
replication factor C (activator 1) 1provided by MGI
Primary source
MGI:MGI:97891
See related
Ensembl:ENSMUSG00000029191 AllianceGenome:MGI:97891
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Recc1; 140kDa; Alp145; RFC140
Summary
Predicted to enable DNA binding activity; DNA clamp unloader activity; and protein domain specific binding activity. Predicted to be involved in DNA clamp unloading; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription, DNA-templated. Located in nucleus. Is expressed in several structures, including adrenal gland; alimentary system; central nervous system; genitourinary system; and retina. Human ortholog(s) of this gene implicated in West Nile fever. Orthologous to human RFC1 (replication factor C subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 10.8), limb E14.5 (RPKM 8.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 C3.1; 5 33.61 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (65419195..65492988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (65261852..65338617, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene kelch-like 5 Neighboring gene predicted gene, 54287 Neighboring gene STARR-positive B cell enhancer ABC_E849 Neighboring gene WD repeat domain 19 Neighboring gene STARR-seq mESC enhancer starr_13260 Neighboring gene STARR-positive B cell enhancer ABC_E6334 Neighboring gene klotho beta Neighboring gene STARR-positive B cell enhancer ABC_E3577 Neighboring gene ribosomal protein L9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning of the large subunit of activator 1 (replication factor C) reveals homology with bacterial DNA ligases. Burbelo PD, et al. Proc Natl Acad Sci U S A, 1993 Dec 15. PMID 8265586, Free PMC Article
  2. Cloning of the murine cDNA encoding VDJP, a protein homologous to the large subunit of replication factor C and bacterial DNA ligases. Halligan BD, et al. Gene, 1995 Aug 19. PMID 7665082
  3. Differentiation-specific element binding protein (DSEB) binds to a defined element in the promoter of the angiotensinogen gene required for the irreversible induction of gene expression during differentiation of 3T3-L1 adipoblasts to adipocytes. McGehee RE Jr, et al. Mol Endocrinol, 1995 Apr. PMID 7659092
  4. Genetic mapping of gene encoding the large subunit of replication factor C (A1-p145) to mouse chromosome 5. Lyu MS, et al. Mamm Genome, 1995 Jul. PMID 7579896
  5. Evaluation of inter- and intramolecular primary structure homologies of interferons by a Monte Carlo method. Wagner F, et al. J Interferon Res, 1990 Feb. PMID 1691767

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC96526

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA clamp loader activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA clamp unloader activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA clamp unloader activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
  
enables double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA repair IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA-templated DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of DNA replication factor C complex ISO
Inferred from Sequence Orthology
more info
  
part_of Elg1 RFC-like complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
replication factor C subunit 1
Names
A1 140 kDa subunit
A1-P145
ISRE-binding protein
RF-C 140 kDa subunit
activator 1 140 kDa subunit
activator 1 large subunit
activator 1 subunit 1
differentiation-specific element-binding protein
replication factor C 1
replication factor C 140 kDa subunit
replication factor C large subunit
replication factor C, 140 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347357.2 → NP_001334286.1  replication factor C subunit 1 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC138654
    Consensus CDS
    CCDS84885.1
    UniProtKB/Swiss-Prot
    P35601
    UniProtKB/TrEMBL
    G3UXL4, Q5U4B1
    Related
    ENSMUSP00000144954.2, ENSMUST00000203471.3

  2. NM_001347358.2 → NP_001334287.1  replication factor C subunit 1 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses two alternate in-frame splice junctions compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC138654
    Consensus CDS
    CCDS84884.1
    UniProtKB/Swiss-Prot
    P35601
    UniProtKB/TrEMBL
    A0A0N5E9G7
    Related
    ENSMUSP00000134444.5, ENSMUST00000172732.8

  3. NM_001421208.1 → NP_001408137.1  replication factor C subunit 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC138654

  4. NM_001421209.1 → NP_001408138.1  replication factor C subunit 1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC138654
    UniProtKB/TrEMBL
    G3UWX1

  5. NM_011258.3 → NP_035388.2  replication factor C subunit 1 isoform 2

    See identical proteins and their annotated locations for NP_035388.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is 1 aa shorter compared to isoform 1.
    Source sequence(s)
    AC138654
    Consensus CDS
    CCDS39096.1
    UniProtKB/Swiss-Prot
    P35601
    UniProtKB/TrEMBL
    G3UZD0, G3X8Z6
    Related
    ENSMUSP00000144980.2, ENSMUST00000204965.3
    Conserved Domains (4) summary
    smart00382
    Location:632 → 762
    AAA; ATPases associated with a variety of cellular activities
    cd00027
    Location:406 → 477
    BRCT; Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo ...
    pfam00004
    Location:632 → 760
    AAA; ATPase family associated with various cellular activities (AAA)
    pfam08519
    Location:899 → 1052
    RFC1; Replication factor RFC1 C terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    65419195..65492988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35601.2 GenPept UniProtKB/Swiss-Prot:P35601

Gene LinkOut

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