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Rdh16 retinol dehydrogenase 16 [ Mus musculus (house mouse) ]

Gene ID: 19683, updated on 21-Apr-2024

Summary

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Official Symbol
Rdh16provided by MGI
Official Full Name
retinol dehydrogenase 16provided by MGI
Primary source
MGI:MGI:1201375
See related
Ensembl:ENSMUSG00000069456 AllianceGenome:MGI:1201375
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CRAD; Rdh6; CRAD1
Summary
Enables NAD-retinol dehydrogenase activity and identical protein binding activity. Involved in retinoid metabolic process and steroid metabolic process. Acts upstream of or within 9-cis-retinoic acid biosynthetic process. Located in endoplasmic reticulum lumen and endoplasmic reticulum membrane. Is integral component of organelle membrane. Is expressed in alimentary system; embryo; future spinal cord; liver; and salivary gland. Orthologous to human RDH16 (retinol dehydrogenase 16). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in kidney adult (RPKM 24.2), liver adult (RPKM 21.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 75.7 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127636959..127651715)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127801090..127815846)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene retinol dehydrogenase 1 (all trans) Neighboring gene STARR-seq mESC enhancer starr_28237 Neighboring gene retinol dehydrogenase 9 Neighboring gene STARR-seq mESC enhancer starr_28238 Neighboring gene STARR-seq mESC enhancer starr_28239 Neighboring gene STARR-seq mESC enhancer starr_28240 Neighboring gene retinol dehydrogenase 18, pseudogene Neighboring gene retinol dehydrogenase 19

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1. Zhang M, et al. J Biol Chem, 2004 Dec 3. PMID 15355969
  2. cDNA cloning and characterization of a cis-retinol/3alpha-hydroxysterol short-chain dehydrogenase. Chai X, et al. J Biol Chem, 1997 Dec 26. PMID 9407098
  3. cis-Retinol/androgen dehydrogenase, isozyme 3 (CRAD3): a short-chain dehydrogenase active in a reconstituted path of 9-cis-retinoic acid biosynthesis in intact cells. Zhuang R, et al. Biochemistry, 2002 Mar 12. PMID 11876656
  4. Quantitative axial profiles of retinoic acid in the embryonic mouse spinal cord: 9-cis retinoic acid only detected after all-trans-retinoic acid levels are super-elevated experimentally. Ulven SM, et al. Dev Dyn, 2001 Nov. PMID 11747070
  5. The C-terminal region of cis-retinol/androgen dehydrogenase 1 (CRAD1) confers ER localization and in vivo enzymatic function. Lidén M, et al. Exp Cell Res, 2005 Dec 10. PMID 16223484

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rdh1, Crad1, and other short-chain dehydrogenases/reductases, which share similar N-terminal signaling sequences such as human Rdh5 and mouse Rdh4, orient with their catalytic domains facing the cytoplasm
    Title: Elements in the N-terminal signaling sequence that determine cytosolic topology of short-chain dehydrogenases/reductases. Studies with retinol dehydrogenase type 1 and cis-retinol/androgen dehydrogenase type 1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC107668

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 11-cis-retinol dehydrogenase IEA
Inferred from Electronic Annotation
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables androsterone dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within 9-cis-retinoic acid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of retinoic acid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in steroid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in steroid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in steroid metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum lumen IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in organelle membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
retinol dehydrogenase 16
Names
cis-retinol/androgen dehydrogenase 1
retinol dehydrogenase 6
retinol dehydrogenase type 6
NP_033066.1
XP_006513452.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009040.3 → NP_033066.1  retinol dehydrogenase 16

    See identical proteins and their annotated locations for NP_033066.1

    Status: VALIDATED

    Source sequence(s)
    AC131690, AF030513, AK149404, BY144003
    Consensus CDS
    CCDS24252.1
    UniProtKB/Swiss-Prot
    O54909
    UniProtKB/TrEMBL
    E9Q9P8
    Related
    ENSMUSP00000071573.2, ENSMUST00000071646.2
    Conserved Domains (1) summary
    cd09805
    Location:30 → 306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127636959..127651715
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513389.3 → XP_006513452.1  retinol dehydrogenase 16 isoform X1

    See identical proteins and their annotated locations for XP_006513452.1

    UniProtKB/Swiss-Prot
    O54909
    UniProtKB/TrEMBL
    E9Q9P8
    Conserved Domains (1) summary
    cd09805
    Location:30 → 306
    type2_17beta_HSD-like_SDR_c; human 17beta-hydroxysteroid dehydrogenase type 2 (type 2 17beta-HSD)-like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O54909.1 GenPept UniProtKB/Swiss-Prot:O54909

Gene LinkOut

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