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Rce1 Ras converting CAAX endopeptidase 1 [ Mus musculus (house mouse) ]

Gene ID: 19671, updated on 21-Apr-2024

Summary

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Official Symbol
Rce1provided by MGI
Official Full Name
Ras converting CAAX endopeptidase 1provided by MGI
Primary source
MGI:MGI:1336895
See related
Ensembl:ENSMUSG00000024889 AllianceGenome:MGI:1336895
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D19Ertd98e; D19Ertd283e
Summary
Predicted to enable exopeptidase activity and metalloendopeptidase activity. Predicted to be involved in CAAX-box protein processing and protein prenylation. Predicted to act upstream of or within proteolysis. Predicted to be located in endoplasmic reticulum membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human RCE1 (Ras converting CAAX endopeptidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 53.2), ovary adult (RPKM 49.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.07 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (4672621..4675673, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (4622593..4625645, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 2010003K11 gene Neighboring gene STARR-positive B cell enhancer ABC_E778 Neighboring gene STARR-seq mESC enhancer starr_45350 Neighboring gene pyruvate carboxylase Neighboring gene leucine rich repeat and fibronectin type III domain containing 4 Neighboring gene microRNA 6986 Neighboring gene TOP6B like initiator of meiotic double strand breaks Neighboring gene spectrin beta, non-erythrocytic 2 Neighboring gene predicted gene 21992

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b. Karlsson C, et al. Leukemia, 2021 Feb. PMID 32398789
  2. Postprenylation CAAX processing is required for proper localization of Ras but not Rho GTPases. Michaelson D, et al. Mol Biol Cell, 2005 Apr. PMID 15659645, Free PMC Article
  3. Hematologic effects of inactivating the Ras processing enzyme Rce1. Aiyagari AL, et al. Blood, 2003 Mar 15. PMID 12433685
  4. Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. Bergo MO, et al. Mol Cell Biol, 2002 Jan. PMID 11739732, Free PMC Article
  5. Rce1 deficiency accelerates the development of K-RAS-induced myeloproliferative disease. Wahlstrom AM, et al. Blood, 2007 Jan 15. PMID 16973961, Free PMC Article

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
    Title: Knockout of the RAS endoprotease RCE1 accelerates myeloid leukemia by downregulating GADD45b.
  2. RCE1 is essential for the intracellular trafficking of PDE6 and survival of photoreceptor cells.
    Title: RAS-converting enzyme 1-mediated endoproteolysis is required for trafficking of rod phosphodiesterase 6 to photoreceptor outer segments.
  3. USP17 modulates Ras processing and activation, at least in part, by regulating RCE1 activity
    Title: USP17 regulates Ras activation and cell proliferation by blocking RCE1 activity.
  4. Hearts from heart-specific Rce1 knockout mice manifested reduced levels of both the Rce1 mRNA and CAAX endoprotease activity, and the hearts manifested an accumulation of CAAX protein substrates. Rce1 knockout mice had a dilated cardiomyopathy.
    Title: On the physiological importance of endoproteolysis of CAAX proteins: heart-specific RCE1 knockout mice develop a lethal cardiomyopathy.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables exopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CAAX-box protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CAAX-box protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein prenylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
CAAX prenyl protease 2
Names
FACE-2
RCE1 homolog, prenyl protein peptidase
Ras and a-factor-converting enzyme 1 homolog
farnesylated proteins-converting enzyme 2
prenyl protein-specific endoprotease 2
NP_001355641.1
NP_001355642.1
NP_001355643.1
NP_001355644.1
NP_075620.1
XP_030106653.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368712.1 → NP_001355641.1  CAAX prenyl protease 2 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC128739
    Conserved Domains (1) summary
    pfam02517
    Location:171 → 216
    Abi; CAAX protease self-immunity

  2. NM_001368713.1 → NP_001355642.1  CAAX prenyl protease 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89304.1
    UniProtKB/TrEMBL
    A0A494B9U4
    Related
    ENSMUSP00000157811.2, ENSMUST00000237022.2
    Conserved Domains (1) summary
    pfam02517
    Location:67 → 112
    Abi; CAAX protease self-immunity

  3. NM_001368714.1 → NP_001355643.1  CAAX prenyl protease 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variant 5, encodes isoform d.
    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89303.1
    UniProtKB/TrEMBL
    A0A286YD70, A0A494BAL8, Q99KQ3
    Conserved Domains (1) summary
    pfam02517
    Location:67 → 162
    Abi; CAAX protease self-immunity

  4. NM_001368715.1 → NP_001355644.1  CAAX prenyl protease 2 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variant 4, encodes isoform d.
    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS89303.1
    UniProtKB/TrEMBL
    A0A286YD70, A0A494BAL8, Q99KQ3
    Related
    ENSMUSP00000153695.2, ENSMUST00000224707.2
    Conserved Domains (1) summary
    pfam02517
    Location:67 → 162
    Abi; CAAX protease self-immunity

  5. NM_023131.2 → NP_075620.1  CAAX prenyl protease 2 isoform b

    See identical proteins and their annotated locations for NP_075620.1

    Status: VALIDATED

    Source sequence(s)
    AC128739
    Consensus CDS
    CCDS29432.1
    UniProtKB/Swiss-Prot
    P57791, Q9CSF8, Q9EP68
    Related
    ENSMUSP00000025823.4, ENSMUST00000025823.6
    Conserved Domains (2) summary
    COG1266
    Location:169 → 269
    YdiL; Membrane protease YdiL, CAAX protease family [Posttranslational modification, protein turnover, chaperones]
    pfam02517
    Location:164 → 267
    Abi; CAAX protease self-immunity

RNA

  1. NR_160877.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  2. NR_160878.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  3. NR_160879.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  4. NR_160880.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  5. NR_160881.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  6. NR_160882.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  7. NR_160883.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739, BC048686
    Related
    ENSMUST00000225476.2

  8. NR_160884.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

  9. NR_160885.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC128739

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    4672621..4675673 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250793.2 → XP_030106653.1  CAAX prenyl protease 2 isoform X1

    UniProtKB/TrEMBL
    A0A494B9U4
    Conserved Domains (1) summary
    pfam02517
    Location:67 → 112
    Abi; CAAX protease self-immunity
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57791.1 GenPept UniProtKB/Swiss-Prot:P57791

Gene LinkOut

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