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Rbpms RNA binding protein gene with multiple splicing [ Mus musculus (house mouse) ]

Gene ID: 19663, updated on 16-Apr-2024

Summary

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Official Symbol
Rbpmsprovided by MGI
Official Full Name
RNA binding protein gene with multiple splicingprovided by MGI
Primary source
MGI:MGI:1334446
See related
Ensembl:ENSMUSG00000031586 AllianceGenome:MGI:1334446
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RBP-MS; hermes; 2010300K22Rik; 2700019M19Rik
Summary
Predicted to enable RNA binding activity; protein homodimerization activity; and transcription coactivator activity. Predicted to be involved in positive regulation of SMAD protein signal transduction; positive regulation of pathway-restricted SMAD protein phosphorylation; and response to oxidative stress. Predicted to be located in cytoplasmic stress granule; cytosol; and nucleoplasm. Is expressed in several structures, including central nervous system; gut; heart; retina; and urinary system. Orthologous to human RBPMS (RNA binding protein, mRNA processing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 24.2), bladder adult (RPKM 22.5) and 20 other tissues See more
Orthologs
human all
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Genomic context

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See Rbpms in Genome Data Viewer
Location:
8 A4; 8 20.85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (34272671..34419925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (33782643..33929922, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700104B16 gene Neighboring gene general transcription factor II E, polypeptide 2 (beta subunit) Neighboring gene STARR-seq mESC enhancer starr_21117 Neighboring gene small integral membrane protein 18 Neighboring gene STARR-seq mESC enhancer starr_21127 Neighboring gene VISTA enhancer mm70 Neighboring gene STARR-seq mESC enhancer starr_21144 Neighboring gene STARR-seq mESC enhancer starr_21145 Neighboring gene predicted gene, 51528 Neighboring gene STARR-seq mESC enhancer starr_21150 Neighboring gene STARR-positive B cell enhancer mm9_chr8:35078702-35079003 Neighboring gene predicted gene, 33588 Neighboring gene STARR-seq mESC enhancer starr_21156 Neighboring gene predicted gene, 39157 Neighboring gene predicted gene, 57792

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Characterization of Sgo1 expression in developing and adult mouse. Song AT, et al. Gene Expr Patterns, 2017 Nov. PMID 28465207
  2. Diversification of multipotential postmitotic mouse retinal ganglion cell precursors into discrete types. Shekhar K, et al. Elife, 2022 Feb 22. PMID 35191836, Free PMC Article
  3. Maf1 regulates axonal regeneration of retinal ganglion cells after injury. Chen D, et al. Exp Neurol, 2022 Feb. PMID 34902358
  4. The RNA-binding protein gene, hermes, is expressed at high levels in the developing heart. Gerber WV, et al. Mech Dev, 1999 Jan. PMID 10096065
  5. Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells. Furukawa MT, et al. Genes Cells, 2015 Apr. PMID 25651939

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
    Title: Comparison of Brn3a and RBPMS Labeling to Assess Retinal Ganglion Cell Loss During Aging and in a Model of Optic Neuropathy.
  2. RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
    Title: RBPMS regulates cardiomyocyte contraction and cardiac function through RNA alternative splicing.
  3. RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
    Title: RBPMS is an RNA-binding protein that mediates cardiomyocyte binucleation and cardiovascular development.
  4. Cytoplasmic granule containing HERMES, NonO, PSF, and G3BP1 is a neuronal RNA-protein granule that is transported in neurites during retinal differentiation.
    Title: Interaction and colocalization of HERMES/RBPMS with NonO, PSF, and G3BP1 in neuronal cytoplasmic RNP granules in mouse retinal line cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA 3'-UTR binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA CDS binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables pre-mRNA intronic binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in SMAD protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in response to oxidative stress ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasmic stress granule ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
RNA-binding protein with multiple splicing
Names
HEart, RRM Expressed Sequence
RNA-binding protein with multiple splicing (RBP-MS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042674.2 → NP_001036139.1  RNA-binding protein with multiple splicing isoform 1

    See identical proteins and their annotated locations for NP_001036139.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    AC162523, AK003434, AK041118
    Consensus CDS
    CCDS40317.1
    UniProtKB/Swiss-Prot
    Q78HG1, Q9CPU5, Q9WVB0
    Related
    ENSMUSP00000055813.5, ENSMUST00000053251.12
    Conserved Domains (1) summary
    cd12682
    Location:23 → 98
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  2. NM_001042675.2 → NP_001036140.1  RNA-binding protein with multiple splicing isoform 3

    See identical proteins and their annotated locations for NP_001036140.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks several exons and includes an alternate 3' terminal exon, compared to variant 1. It encodes isoform 3 which is longer and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC162523, AK012265
    Consensus CDS
    CCDS40318.1
    UniProtKB/Swiss-Prot
    Q9WVB0
    Related
    ENSMUSP00000033995.7, ENSMUST00000033995.14
    Conserved Domains (1) summary
    cd12682
    Location:23 → 98
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  3. NM_001286168.1 → NP_001273097.1  RNA-binding protein with multiple splicing isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an exon in the 3' coding region, which results in a frameshift, compared to variant 1. This results in a shorter protein (isoform 4) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC162523, AK003434, AK079238
    Consensus CDS
    CCDS72112.1
    UniProtKB/TrEMBL
    Q8C586, T1ECW4
    Related
    ENSMUSP00000033994.9, ENSMUST00000033994.15
    Conserved Domains (1) summary
    cd12682
    Location:23 → 98
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  4. NM_019733.3 → NP_062707.1  RNA-binding protein with multiple splicing isoform 1

    See identical proteins and their annotated locations for NP_062707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC162523, AK003434, AK041118, AK079238
    Consensus CDS
    CCDS40317.1
    UniProtKB/Swiss-Prot
    Q78HG1, Q9CPU5, Q9WVB0
    Related
    ENSMUSP00000140387.2, ENSMUST00000191473.7
    Conserved Domains (1) summary
    cd12682
    Location:23 → 98
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    34272671..34419925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509037.4 → XP_006509100.3  RNA-binding protein with multiple splicing isoform X4

    Conserved Domains (1) summary
    cd12682
    Location:40 → 115
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  2. XM_006509035.5 → XP_006509098.1  RNA-binding protein with multiple splicing isoform X2

    Conserved Domains (1) summary
    cd12682
    Location:23 → 98
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  3. XM_006509034.5 → XP_006509097.1  RNA-binding protein with multiple splicing isoform X1

    Conserved Domains (1) summary
    cd12682
    Location:40 → 115
    RRM_RBPMS; RNA recognition motif in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

  4. XM_036153838.1 → XP_036009731.1  RNA-binding protein with multiple splicing isoform X3

    Conserved Domains (1) summary
    cd12682
    Location:40 → 115
    RRM_RBPMS; RNA recognition motif (RRM) found in vertebrate RNA-binding protein with multiple splicing (RBP-MS)

RNA

  1. XR_378783.4 RNA Sequence

  2. XR_378781.4 RNA Sequence

  3. XR_378782.3 RNA Sequence

  4. XR_378780.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WVB0.2 GenPept UniProtKB/Swiss-Prot:Q9WVB0

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