Rbp2 retinol binding protein 2, cellular [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rbp2provided by MGI
Official Full Name: retinol binding protein 2, cellularprovided by MGI
Primary source: MGI:MGI:97877
See related: Ensembl:ENSMUSG00000032454 AllianceGenome:MGI:97877
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rbp-2; Crbp-2; CrbpII
Summary: Predicted to enable fatty acid binding activity and retinol binding activity. Predicted to be involved in fatty acid transport. Predicted to act upstream of or within retinoid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Is expressed in embryo; intestine; lower jaw tooth; and tooth. Orthologous to human RBP2 (retinol binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 216.6), small intestine adult (RPKM 147.9) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 E3.3; 9 51.37 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (98372590..98391824)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (98490537..98509771)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.
Title: Retinol-binding protein 2 (RBP2) binds monoacylglycerols and modulates gut endocrine signaling and body weight.
study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses
Title: Chromatin remodeling: demethylating H3K4me3 of type I IFNs gene by Rbp2 through interacting with Piasy for transcriptional attenuation.
genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release
Title: Efficient stimulus-secretion coupling at ribbon synapses requires RIM-binding protein tethering of L-type Ca(2+) channels.
RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
Title: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes.
Title: Expression of histone H3 lysine 4 methylation and its demethylases in the developing mouse testis.
genetic ablation of Rbp2 decreases tumor formation and prolongs survival in Rb1(+/-) mice and Men1-defective mice.
Title: Loss of the retinoblastoma binding protein 2 (RBP2) histone demethylase suppresses tumorigenesis in mice lacking Rb1 or Men1.
DGAT1 is an important intestinal acyl-CoA:retinol acyltransferase; does not directly prevent retinol from being acted upon by DGAT1 or other intestinal ARATs in vivo
Title: The molecular basis of retinoid absorption: a genetic dissection.
RBP2 knockout mice have a higher rate of neonatal mortality and expression of CRBPII in the placenta
Title: Increased neonatal mortality in mice lacking cellular retinol-binding protein II.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:495477

NoName (e-PCR)
- UniSTS:484982

Rbp2 (e-PCR), detects polymorphism
- UniSTS:186535

D9Mit211 (e-PCR), detects polymorphism
- UniSTS:131767

D9Mit211.1 (e-PCR), detects polymorphism
- UniSTS:131768

D9Mit211.3 (e-PCR), detects polymorphism
- UniSTS:131769

D8Wox6 (e-PCR)
- UniSTS:118010

D9Kyo1 (e-PCR), detects polymorphism
- UniSTS:118010

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables binding	IDA Inferred from Direct Assay more info	PubMed
enables binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables fatty acid binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IDA Inferred from Direct Assay more info	PubMed
enables lipid binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables retinal binding	IEA Inferred from Electronic Annotation more info
enables retinoid binding	TAS Traceable Author Statement more info	PubMed
enables retinol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in fatty acid transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoid metabolic process	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: retinol-binding protein 2

Names: CRBP-II; cellular retinol-binding protein II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.