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Rbm3 RNA binding motif (RNP1, RRM) protein 3 [ Mus musculus (house mouse) ]

Gene ID: 19652, updated on 11-Apr-2024

Summary

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Official Symbol
Rbm3provided by MGI
Official Full Name
RNA binding motif (RNP1, RRM) protein 3provided by MGI
Primary source
MGI:MGI:1099460
See related
Ensembl:ENSMUSG00000031167 AllianceGenome:MGI:1099460
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2600016C11Rik
Summary
Enables ribosomal large subunit binding activity. Involved in regulation of translation. Acts upstream of or within production of miRNAs involved in gene silencing by miRNA; response to cold; and translation. Predicted to be located in cytoplasm; dendrite; and nucleoplasm. Predicted to be part of spliceosomal complex. Is expressed in several structures, including central nervous system; ovary; and sensory organ. Orthologous to human RBM3 (RNA binding motif protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 50.1), liver E14 (RPKM 45.8) and 22 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X A1.1; X 3.68 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (8005214..8012119, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (8138975..8145880, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene proteasome (prosome, macropain) subunit, beta type 7 pseudogene Neighboring gene proteasome (prosome, macropain) subunit, beta type 7, pseudogene 2 Neighboring gene STARR-positive B cell enhancer ABC_E7686 Neighboring gene WD repeat domain 13 Neighboring gene RNA binding motif protein 3, opposite strand Neighboring gene TBC1 domain family, member 25 Neighboring gene STARR-seq mESC enhancer starr_46689 Neighboring gene STARR-seq mESC enhancer starr_46690 Neighboring gene EBP cholestenol delta-isomerase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3). Hettinger ZR, et al. Physiol Rep, 2023 Feb. PMID 36750123, Free PMC Article
  2. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure. Liu Y, et al. Cell Stress Chaperones, 2022 Nov. PMID 36149580, Free PMC Article
  3. RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury. Feng J, et al. J Surg Res, 2021 May. PMID 33460967
  4. The Expression of the Cold Shock Protein RNA Binding Motif Protein 3 is Transcriptionally Responsive to Organ Temperature in Mice. Ushio A, et al. Protein Pept Lett, 2021. PMID 32972335
  5. The RNA-Binding Protein RBM3 Promotes Neural Stem Cell (NSC) Proliferation Under Hypoxia. Yan J, et al. Front Cell Dev Biol, 2019. PMID 31824945, Free PMC Article

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
    Title: RBM3 Accelerates Wound Healing of Skin in Diabetes through ERK1/2 Signaling.
  2. Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation/reoxygenation cell model.
    Title: Study on the protective effect of RNA-binding motif protein 3 in mild hypothermia oxygen-glucose deprivation/reoxygenation cell model.
  3. Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.
    Title: Chronic social stress blunts core body temperature and molecular rhythms of Rbm3 and Cirbp in mouse lateral habenula.
  4. RBM3 is associated with acute lung injury in septic mice and patients via the NF-kappaB/NLRP3 pathway.
    Title: RBM3 is associated with acute lung injury in septic mice and patients via the NF-κB/NLRP3 pathway.
  5. The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).
    Title: The transcript interactome of skeletal muscle RNA binding protein motif 3 (RBM3).
  6. RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
    Title: RNA binding motif protein 3 (RBM3) promotes protein kinase B (AKT) activation to enhance glucose metabolism and reduce apoptosis in skeletal muscle of mice under acute cold exposure.
  7. RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
    Title: RNA-binding protein RBM3 intrinsically suppresses lung innate lymphoid cell activation and inflammation partially through CysLT1R.
  8. Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.
    Title: Skeletal muscle RBM3 expression is associated with extended lifespan in Ames Dwarf and calorie restricted mice.
  9. TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
    Title: TrkB signaling regulates the cold-shock protein RBM3-mediated neuroprotection.
  10. RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury.
    Title: RBM3 Increases Cell Survival but Disrupts Tight Junction of Microvascular Endothelial Cells in Acute Lung Injury.
Submit: New GeneRIF Correction See all GeneRIFs (24)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC118410

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within miRNA processing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within response to cold IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within translation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite ISO
Inferred from Sequence Orthology
more info
  
part_of large ribosomal subunit ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNA-binding protein 3
Names
RNA binding motif protein 3
putative RNA-binding protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166409.2 → NP_001159881.1  RNA-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001159881.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site and alternate terminal exon in the 3' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AK133795, AL663032, BB050916, BC106176, CN696660
    Consensus CDS
    CCDS29987.1
    UniProtKB/TrEMBL
    Q8BG13
    Related
    ENSMUSP00000111280.4, ENSMUST00000115617.10
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  2. NM_001166410.2 → NP_001159882.1  RNA-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001159882.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region and alternate 3' terminal exon, compared to variant 1. The encoded protein (isoform 2) has a shorter protein, compared to isoform 1.
    Source sequence(s)
    AL663032, BB050916, BC106176
    Consensus CDS
    CCDS52988.1
    UniProtKB/Swiss-Prot
    O89086
    UniProtKB/TrEMBL
    Q545K5, Q5RJV3
    Related
    ENSMUSP00000111284.3, ENSMUST00000115621.9
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  3. NM_001166411.2 → NP_001159883.1  RNA-binding protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001159883.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 3' coding region and differs in the 3' UTR, compared to variant 1. The encoded protein (isoform 2) has a shorter protein, compared to isoform 1.
    Source sequence(s)
    AK133795, AL663032, BB050916, BC106176
    Consensus CDS
    CCDS52988.1
    UniProtKB/Swiss-Prot
    O89086
    UniProtKB/TrEMBL
    Q545K5, Q5RJV3
    Related
    ENSMUSP00000111277.3, ENSMUST00000115615.9
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  4. NM_001293658.1 → NP_001280587.1  RNA-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_001280587.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate terminal exon in the 3' UTR, compared to variant 1. Variants 1, 2, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AL663032, BB050916, BC086491, BC106176
    Consensus CDS
    CCDS29987.1
    UniProtKB/TrEMBL
    Q8BG13
    Related
    ENSMUSP00000111279.2, ENSMUST00000115616.8
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  5. NM_016809.6 → NP_058089.2  RNA-binding protein 3 isoform 1

    See identical proteins and their annotated locations for NP_058089.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer protein (isoform 1). Variants 1, 2, and 5 encode the same protein (isoform 1).
    Source sequence(s)
    AK011224, AK049575, AL663032, BC106176
    Consensus CDS
    CCDS29987.1
    UniProtKB/TrEMBL
    Q8BG13
    Related
    ENSMUSP00000038964.4, ENSMUST00000040010.10
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    8005214..8012119 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O89086.1 GenPept UniProtKB/Swiss-Prot:O89086

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