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RMST rhabdomyosarcoma 2 associated transcript [ Homo sapiens (human) ]

Gene ID: 196475, updated on 6-Nov-2023

Summary

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Official Symbol
RMSTprovided by HGNC
Official Full Name
rhabdomyosarcoma 2 associated transcriptprovided by HGNC
Primary source
HGNC:HGNC:29893
See related
Ensembl:ENSG00000255794 MIM:607045; AllianceGenome:HGNC:29893
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCRMS; LINC00054; NCRNA00054
Summary
This gene produces a long non-coding RNA that functions in neurogenesis by aiding in the association of Sox2 transcription factor to its target promoters. [provided by RefSeq, Dec 2017]
Expression
Biased expression in thyroid (RPKM 2.9), prostate (RPKM 0.5) and 1 other tissue See more
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Genomic context

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Location:
12q23.1; 12q21
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (97462804..97565035)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (97436013..97538218)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (97856554..97958793)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928912 Neighboring gene NANOG hESC enhancer GRCh37_chr12:97628866-97629367 Neighboring gene uncharacterized LOC105369930 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:97668725-97669520 Neighboring gene long intergenic non-protein coding RNA 2409 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97857979-97858802 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:97858803-97859626 Neighboring gene NANOG hESC enhancer GRCh37_chr12:97913914-97914415 Neighboring gene microRNA 1251 Neighboring gene NFE2L2 motif-containing MPRA enhancer 214 Neighboring gene microRNA 135a-2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98002200-98002744 Neighboring gene NANOG hESC enhancer GRCh37_chr12:98033470-98033981 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr12:98050058-98050648 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4749 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:98117503-98118004 Neighboring gene PAFAH1B2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr12:98145599-98146798 Neighboring gene RNA, U6 small nuclear 36, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:98178628-98179251 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:98291588-98292138 Neighboring gene microRNA 4495

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. LncRNA RMST Regulates Neuronal Apoptosis and Inflammatory Response via Sponging miR-150-5p in Parkinson's Disease. Chen C, et al. Neuroimmunomodulation, 2022. PMID 34515176
  2. Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma. Rickert D, et al. Acta Neuropathol, 2021 Jun. PMID 33866410, Free PMC Article
  3. Knockdown of RMST Impedes Neuronal Apoptosis and Oxidative Stress in OGD/R-Induced Ischemic Stroke Via Depending on the miR-377/SEMA3A Signal Network. Zhao L, et al. Neurochem Res, 2021 Mar. PMID 33409855
  4. Long non-coding RNA (LncRNA) RMST in triple-negative breast cancer (TNBC): Expression analysis and biological roles research. Wang L, et al. J Cell Physiol, 2018 Oct. PMID 29215701
  5. Integrative transcriptome sequencing identifies trans-splicing events with important roles in human embryonic stem cell pluripotency. Wu CS, et al. Genome Res, 2014 Jan. PMID 24131564, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Long non-coding RNA RMST serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of cerebral ischemic event: A retrospective study.
    Title: Long non-coding RNA RMST serves as a diagnostic biomarker in patients with carotid artery stenosis and predicts the occurrence of cerebral ischemic event: A retrospective study.
  2. lncRNA RMST suppresses the progression of colorectal cancer by competitively binding to miR-27a-3p/RXRalpha axis and inactivating Wnt signaling pathway.
    Title: lncRNA RMST suppresses the progression of colorectal cancer by competitively binding to miR-27a-3p/RXRα axis and inactivating Wnt signaling pathway.
  3. LncRNA RMST Regulates Neuronal Apoptosis and Inflammatory Response via Sponging miR-150-5p in Parkinson's Disease.
    Title: LncRNA RMST Regulates Neuronal Apoptosis and Inflammatory Response via Sponging miR-150-5p in Parkinson's Disease.
  4. Abnormal expression of long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) participates in the pathological mechanism of atherosclerosis by regulating miR-224-3p.
    Title: Abnormal expression of long non-coding RNA rhabdomyosarcoma 2-associated transcript (RMST) participates in the pathological mechanism of atherosclerosis by regulating miR-224-3p.
  5. Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.
    Title: Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.
  6. Long non-coding RNA RMST promotes oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells by regulating miR-204-5p/VCAM1 axis.
    Title: Long non-coding RNA RMST promotes oxygen-glucose deprivation-induced injury in brain microvascular endothelial cells by regulating miR-204-5p/VCAM1 axis.
  7. Knockdown of RMST Impedes Neuronal Apoptosis and Oxidative Stress in OGD/R-Induced Ischemic Stroke Via Depending on the miR-377/SEMA3A Signal Network.
    Title: Knockdown of RMST Impedes Neuronal Apoptosis and Oxidative Stress in OGD/R-Induced Ischemic Stroke Via Depending on the miR-377/SEMA3A Signal Network.
  8. RMST overexpression could also restrain the invasion and migration abilities of triple-negative breast cancer cells. RMST played a role of tumor suppressor in triple-negative breast cancer through inhibiting cell proliferation, invasion and migration, enhancing cell apoptosis, and regulating cell cycle.
    Title: Long non-coding RNA (LncRNA) RMST in triple-negative breast cancer (TNBC): Expression analysis and biological roles research.
  9. disruption of trans-spliced noncoding RNA RMST expression in human embryonic stem cells results in the upregulation of WNT5A, epithelial-to-mesenchymal transition, and lineage-specific genes/markers.
    Title: The Trans-Spliced Long Noncoding RNA tsRMST Impedes Human Embryonic Stem Cell Differentiation Through WNT5A-Mediated Inhibition of the Epithelial-to-Mesenchymal Transition.
  10. RMST is required for the binding of SOX2 to promoter regions of neurogenic transcription factors. These results establish the role of RMST as a transcriptional coregulator of SOX2 and a key player in the regulation of neural stem cell fate.
    Title: The long noncoding RNA RMST interacts with SOX2 to regulate neurogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Markers

Other Names

  • long intergenic non-protein coding RNA 54
  • non-coding RNA in rhabdomyosarcoma (RMS)
  • rhabdomyosarcoma 2 associated transcript (non-coding RNA)
  • rhabdomyosarcoma 2 associated transcript (non-protein coding)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024037.3 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000541282.5

  2. NR_152618.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000670745.1

  3. NR_186051.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  4. NR_186052.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  5. NR_186053.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  6. NR_186054.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  7. NR_186055.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  8. NR_186056.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  9. NR_186057.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  10. NR_186058.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000701029.1

  11. NR_186059.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  12. NR_186060.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000664685.1

  13. NR_186061.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  14. NR_186062.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000656448.1

  15. NR_186063.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000640149.1

  16. NR_186064.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  17. NR_186065.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  18. NR_186066.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  19. NR_186067.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  20. NR_186068.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000660138.1

  21. NR_186069.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000690227.1

  22. NR_186070.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  23. NR_186071.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  24. NR_186072.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  25. NR_186073.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  26. NR_186074.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  27. NR_186076.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  28. NR_186077.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  29. NR_186078.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  30. NR_186079.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000687565.1

  31. NR_186080.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000687746.1

  32. NR_186081.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  33. NR_186087.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  34. NR_186088.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  35. NR_186089.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  36. NR_186090.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000639542.1

  37. NR_186091.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  38. NR_186092.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000654331.1

  39. NR_186093.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000689144.1

  40. NR_186094.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  41. NR_186095.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  42. NR_186096.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659
    Related
    ENST00000657936.1

  43. NR_186097.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  44. NR_186098.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  45. NR_186099.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  46. NR_186100.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  47. NR_186101.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  48. NR_186102.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  49. NR_186103.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  50. NR_186104.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  51. NR_186105.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

  52. NR_186106.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007351, AC018659

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    97462804..97565035
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    97436013..97538218
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
Molecular Biology Databases
Research Materials