U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRXL2C peroxiredoxin like 2C [ Homo sapiens (human) ]

Gene ID: 195827, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
PRXL2Cprovided by HGNC
Official Full Name
peroxiredoxin like 2Cprovided by HGNC
Primary source
HGNC:HGNC:16881
See related
Ensembl:ENSG00000158122 AllianceGenome:HGNC:16881
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AAED1; C9orf21
Summary
Predicted to enable antioxidant activity. Involved in positive regulation of ERK1 and ERK2 cascade and positive regulation of glycolytic process. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 7.8), gall bladder (RPKM 7.6) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PRXL2C in Genome Data Viewer
Location:
9q22.33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (96639577..96655317, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (108811352..108827123, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (99401859..99417599, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20083 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20084 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20085 Neighboring gene hyaluronan binding protein 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99256389-99257179 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99257792-99258292 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99273815-99274314 Neighboring gene cell division cycle 14B Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr9:99284685-99285884 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20086 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20087 Neighboring gene MPRA-validated peak7299 silencer Neighboring gene uncharacterized LOC105376163 Neighboring gene MPRA-validated peak7301 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:99381276-99381776 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20088 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20089 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20090 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:99428933-99429433 Neighboring gene Sharpr-MPRA regulatory region 12242 Neighboring gene makorin ring finger protein 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20091 Neighboring gene zinc finger protein 510

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. AAED1 modulates proliferation and glycolysis in gastric cancer. Zhang B, et al. Oncol Rep, 2018 Aug. PMID 29901208
  2. Fugu and human sequence comparison identifies novel human genes and conserved non-coding sequences. Gilligan P, et al. Gene, 2002 Jul 10. PMID 12234665
  3. Reconsidering the evolution of eukaryotic selenoproteins: a novel nonmammalian family with scattered phylogenetic distribution. Castellano S, et al. EMBO Rep, 2004 Jan. PMID 14710190, Free PMC Article
  4. DNA sequence and analysis of human chromosome 9. Humphray SJ, et al. Nature, 2004 May 27. PMID 15164053, Free PMC Article
  5. Transcriptome analysis of human gastric cancer. Oh JH, et al. Mamm Genome, 2005 Dec. PMID 16341674

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
peroxiredoxin-like 2C
Names
AhpC/TSA antioxidant enzyme domain containing 1
UPF0308 protein C9orf21
ahpC/TSA antioxidant enzyme domain-containing protein 1
thioredoxin-like protein AAED1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_153698.2 → NP_714542.1  peroxiredoxin-like 2C

    See identical proteins and their annotated locations for NP_714542.1

    Status: VALIDATED

    Source sequence(s)
    AL353578, BF445089, BM843088, BU631382
    Consensus CDS
    CCDS35073.1
    UniProtKB/Swiss-Prot
    B2RMW4, Q5JU02, Q7RTV5
    Related
    ENSP00000364382.3, ENST00000375234.8
    Conserved Domains (1) summary
    cd02970
    Location:34 → 195
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    96639577..96655317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422905.1 → XP_047278861.1  peroxiredoxin-like 2C isoform X3

    Related
    ENSP00000412378.1, ENST00000411939.5

  2. XM_005251784.5 → XP_005251841.1  peroxiredoxin-like 2C isoform X2

    See identical proteins and their annotated locations for XP_005251841.1

    UniProtKB/TrEMBL
    B7ZKK1, H0Y5J5
    Related
    ENSP00000398933.1, ENST00000446045.1
    Conserved Domains (1) summary
    cd02970
    Location:11 → 141
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. XM_005251783.4 → XP_005251840.1  peroxiredoxin-like 2C isoform X1

    See identical proteins and their annotated locations for XP_005251840.1

    Conserved Domains (1) summary
    cd02970
    Location:34 → 168
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    108811352..108827123 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362236.1 → XP_054218211.1  peroxiredoxin-like 2C isoform X3

  2. XM_054362235.1 → XP_054218210.1  peroxiredoxin-like 2C isoform X2

    UniProtKB/TrEMBL
    B7ZKK1

  3. XM_054362234.1 → XP_054218209.1  peroxiredoxin-like 2C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7RTV5.1 GenPept UniProtKB/Swiss-Prot:Q7RTV5

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous