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Skint3 selection and upkeep of intraepithelial T cells 3 [ Mus musculus (house mouse) ]

Gene ID: 195564, updated on 8-Feb-2024

Summary

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Official Symbol
Skint3provided by MGI
Official Full Name
selection and upkeep of intraepithelial T cells 3provided by MGI
Primary source
MGI:MGI:3045331
See related
Ensembl:ENSMUSG00000070868 AllianceGenome:MGI:3045331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Skint-3; A430090E18Rik
Summary
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in external side of plasma membrane. Is expressed in skin and thymus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See Skint3 in Genome Data Viewer
Location:
4 D1; 4 51.53 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (112089442..112157665)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (112232245..112300468)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene selection and upkeep of intraepithelial T cells 1 Neighboring gene STARR-seq mESC enhancer starr_11099 Neighboring gene selection and upkeep of intraepithelial T cells 4 Neighboring gene selection and upkeep of intraepithelial T cells 9 Neighboring gene predicted gene 12819

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Skint1, the prototype of a newly identified immunoglobulin superfamily gene cluster, positively selects epidermal gammadelta T cells. Boyden LM, et al. Nat Genet, 2008 May. PMID 18408721, Free PMC Article
  2. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables signaling receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
selection and upkeep of intraepithelial T-cells protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102474.2 → NP_001095944.1  selection and upkeep of intraepithelial T-cells protein 3 isoform a precursor

    See identical proteins and their annotated locations for NP_001095944.1

    Status: VALIDATED

    Source sequence(s)
    AK040383, AL611968, EF494894
    Consensus CDS
    CCDS51268.1
    UniProtKB/Swiss-Prot
    A7TZF0, A7TZF2, Q8BIN0
    Related
    ENSMUSP00000131300.2, ENSMUST00000170945.2
    Conserved Domains (3) summary
    cd05713
    Location:42 → 141
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:35 → 140
    IG_like; Immunoglobulin like
    cl11960
    Location:159 → 221
    Ig; Immunoglobulin domain

  2. NM_001348354.1 → NP_001335283.1  selection and upkeep of intraepithelial T-cells protein 3 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AK040383, AL611968, EF494896
    UniProtKB/Swiss-Prot
    A7TZF0
    Conserved Domains (1) summary
    cl11960
    Location:38 → 104
    Ig; Immunoglobulin domain

  3. NM_177578.4 → NP_808246.1  selection and upkeep of intraepithelial T-cells protein 3 isoform b precursor

    See identical proteins and their annotated locations for NP_808246.1

    Status: VALIDATED

    Source sequence(s)
    AL611968
    Consensus CDS
    CCDS38838.1
    UniProtKB/Swiss-Prot
    A7TZF0
    Related
    ENSMUSP00000042662.6, ENSMUST00000038455.12
    Conserved Domains (3) summary
    cd05713
    Location:42 → 141
    Ig_MOG_like; Immunoglobulin (Ig)-like domain of myelin oligodendrocyte glycoprotein (MOG)
    smart00410
    Location:35 → 140
    IG_like; Immunoglobulin like
    cl11960
    Location:159 → 221
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    112089442..112157665
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A7TZF0.1 GenPept UniProtKB/Swiss-Prot:A7TZF0

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