Gsc2 goosecoid homebox 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Gsc2provided by MGI
Official Full Name: goosecoid homebox 2provided by MGI
Primary source: MGI:MGI:892006
See related: Ensembl:ENSMUSG00000022738 AllianceGenome:MGI:892006
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gscl; GSC-2; 4930568H22Rik
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; gut; and retina. Orthologous to human GSC2 (goosecoid homeobox 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in stomach adult (RPKM 1.7), testis adult (RPKM 1.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 A3; 16 11.1 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (17730978..17732891, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (17913114..17915027, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results indicate that the absence of Gscl and Dgcr14 in the IP results in altered regulation of REM sleep
Title: Loss of Goosecoid-like and DiGeorge syndrome critical region 14 in interpeduncular nucleus results in altered regulation of rapid eye movement sleep.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Gscl (e-PCR), detects polymorphism
- UniSTS:260491

Gscl (e-PCR), detects polymorphism
- UniSTS:260492

Gscl (e-PCR), detects polymorphism
- UniSTS:143271

UniSTS:495797 (e-PCR)
- UniSTS:495797

UniSTS:256469 (e-PCR)
- UniSTS:256469

Gscl (e-PCR), detects polymorphism
- UniSTS:256469

Gscl (e-PCR), detects polymorphism
- UniSTS:265713

NoName (e-PCR)
- UniSTS:487665

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: homeobox protein goosecoid-2

Names: GSC-L

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029469.2 → NP_083745.2 homeobox protein goosecoid-2

Status: VALIDATED

Source sequence(s)

AK016252, BC125356

Consensus CDS

CCDS49786.2

UniProtKB/Swiss-Prot

A2RTU1, P56916, Q05A98

UniProtKB/TrEMBL

A0A8Q0LQJ1

Related

ENSMUSP00000012279.5, ENSMUST00000012279.6

Conserved Domains (1) summary

pfam00046
Location:126 → 180

Homeobox; Homeobox domain