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Dcdc2a doublecortin domain containing 2a [ Mus musculus (house mouse) ]

Gene ID: 195208, updated on 11-Apr-2024

Summary

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Official Symbol
Dcdc2aprovided by MGI
Official Full Name
doublecortin domain containing 2aprovided by MGI
Primary source
MGI:MGI:2652818
See related
Ensembl:ENSMUSG00000035910 AllianceGenome:MGI:2652818
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RU2; Dcdc2; AW492955
Summary
This gene encodes a member of the doublecortin family. The protein encoded by this gene contains two doublecortin domains. The doublecortin domain has been demonstrated to bind tubulin and enhance microtubule polymerization. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
13 A3.1; 13 10.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (25239126..25394689)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (25055273..25210706)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene glycosylphosphatidylinositol specific phospholipase D1 Neighboring gene microRNA 12184 Neighboring gene MRS2 magnesium transporter Neighboring gene predicted gene, 52042 Neighboring gene STARR-positive B cell enhancer mm9_chr13:25142251-25142552 Neighboring gene STARR-seq mESC enhancer starr_33992 Neighboring gene STARR-seq mESC enhancer starr_33993 Neighboring gene STARR-seq mESC enhancer starr_33994 Neighboring gene neurensin 1 Neighboring gene predicted gene, 34122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Evaluation of visual motion perception ability in mice with knockout of the dyslexia candidate susceptibility gene Dcdc2. Rendall AR, et al. Genes Brain Behav, 2019 Jun. PMID 29232042
  2. Mutation of the Dyslexia-Associated Gene Dcdc2 Enhances Glutamatergic Synaptic Transmission Between Layer 4 Neurons in Mouse Neocortex. Che A, et al. Cereb Cortex, 2016 Sep. PMID 26250775, Free PMC Article
  3. Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability. Truong DT, et al. Genes Brain Behav, 2014 Nov. PMID 25130614, Free PMC Article
  4. The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex. Che A, et al. Biol Psychiatry, 2014 Sep 1. PMID 24094509, Free PMC Article
  5. Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice. Gabel LA, et al. Genes Brain Behav, 2011 Nov. PMID 21883923, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Dcdc2 KOs displayed deficits on the Pairwise Discrimination task specifically as motion was added to visual stimuli.
    Title: Evaluation of visual motion perception ability in mice with knockout of the dyslexia candidate susceptibility gene Dcdc2.
  2. Behavioral results revealed deficits in rapid auditory processing, working memory and reference memory in Dcdc2(del2/del2) mice when compared with matched wild types.
    Title: Mutation of Dcdc2 in mice leads to impairments in auditory processing and memory ability.
  3. Results link the function of the dyslexia-associated gene Dcdc2 to spike timing through activity of N-methyl-D-aspartate receptor (NMDAR)
    Title: The dyslexia-associated gene DCDC2 is required for spike-timing precision in mouse neocortex.
  4. These results indicate that Dcdc2 is not required for neurogenesis, neuronal migration or differentiation in mice, but may have partial functional redundancy with doublecortin.
    Title: Dcdc2 knockout mice display exacerbated developmental disruptions following knockdown of doublecortin.
  5. heterozygous and homozygous mutations of Dcdc2 result in persistent visuo-spatial memory deficits, as well as visual discrimination and long-term memory deficits
    Title: Mutation of the dyslexia-associated gene Dcdc2 impairs LTM and visuo-spatial performance in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

General gene information

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Markers

Homology

Clone Names

  • MGC54817

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables kinesin binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in dendrite morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dendrite morphogenesis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within neuron migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuronal action potential IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of smoothened signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of sensory perception of sound IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
is_active_in kinocilium IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in kinocilium ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in microtubule cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitotic spindle ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
doublecortin domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195617.1 → NP_001182546.1  doublecortin domain-containing protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001182546.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 3' exons, but has a unique 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1. The isoform 2 retains two doublecortin domains.
    Source sequence(s)
    BC045136
    Consensus CDS
    CCDS56873.1
    UniProtKB/Swiss-Prot
    Q5DU00
    Related
    ENSMUSP00000047641.9, ENSMUST00000036932.15
    Conserved Domains (2) summary
    cd01617
    Location:17 → 96
    DCX; Ubiquitin-like domain of DCX
    smart00537
    Location:134 → 221
    DCX; Domain in the Doublecortin (DCX) gene product

  2. NM_177577.3 → NP_808245.2  doublecortin domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_808245.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK220370, AL589735, AW492955, BC045136
    Consensus CDS
    CCDS26386.2
    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    UniProtKB/TrEMBL
    R4GML1
    Related
    ENSMUSP00000063650.7, ENSMUST00000069614.7
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 466
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    25239126..25394689
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011244294.4 → XP_011242596.1  doublecortin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242596.1

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 480
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. XM_006516604.4 → XP_006516667.1  doublecortin domain-containing protein 2 isoform X2

    See identical proteins and their annotated locations for XP_006516667.1

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    UniProtKB/TrEMBL
    R4GML1
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 466
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. XM_011244291.3 → XP_011242593.1  doublecortin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242593.1

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 480
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  4. XM_036157923.1 → XP_036013816.1  doublecortin domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    UniProtKB/TrEMBL
    R4GML1
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 466
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  5. XM_011244292.1 → XP_011242594.1  doublecortin domain-containing protein 2 isoform X1

    See identical proteins and their annotated locations for XP_011242594.1

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 480
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  6. XM_036157924.1 → XP_036013817.1  doublecortin domain-containing protein 2 isoform X2

    UniProtKB/Swiss-Prot
    Q5DU00, Q5SZU0, Q80Y99
    UniProtKB/TrEMBL
    R4GML1
    Conserved Domains (4) summary
    PRK08163
    Location:69 → 138
    PRK08163; 3-hydroxybenzoate 6-monooxygenase
    TIGR00927
    Location:246 → 466
    2A1904; K+-dependent Na+/Ca+ exchanger
    cd17152
    Location:138 → 217
    DCX2_DCDC2; Doublecortin-like domain 2 found in doublecortin domain-containing protein 2 (DCDC2)
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  7. XM_036157925.1 → XP_036013818.1  doublecortin domain-containing protein 2 isoform X3

    Conserved Domains (2) summary
    TIGR00927
    Location:111 → 343
    2A1904; K+-dependent Na+/Ca+ exchanger
    cl28922
    Location:17 → 96
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5DU00.2 GenPept UniProtKB/Swiss-Prot:Q5DU00

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