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Zzef1 zinc finger, ZZ-type with EF hand domain 1 [ Mus musculus (house mouse) ]

Gene ID: 195018, updated on 2-May-2024

Summary

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Official Symbol
Zzef1provided by MGI
Official Full Name
zinc finger, ZZ-type with EF hand domain 1provided by MGI
Primary source
MGI:MGI:2444286
See related
Ensembl:ENSMUSG00000055670 AllianceGenome:MGI:2444286
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
NSPA; mKIAA0399; 8430405D05Rik; C130099L13Rik
Summary
Enables ubiquitin-like protein ligase activity. Acts upstream of or within several processes, including glutamatergic synaptic transmission; regulation of peptidyl-tyrosine phosphorylation; and visual learning. Located in cell surface; postsynapse; and presynaptic active zone. Is expressed in several structures, including adipose tissue; alimentary system; immune system; nervous system; and reproductive system. Orthologous to human ZZEF1 (zinc finger ZZ-type and EF-hand domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 16.1), small intestine adult (RPKM 15.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B4; 11 44.56 cM
Exon count:
56
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (72686976..72817946)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (72796150..72927120)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and FYVE domain containing 1 Neighboring gene predicted gene, 46287 Neighboring gene STARR-positive B cell enhancer ABC_E8424 Neighboring gene cytochrome b5 domain containing 2 Neighboring gene signal recognition particle receptor ('docking protein') pseudogene Neighboring gene predicted gene, 26121 Neighboring gene predicted gene, 34704 Neighboring gene predicted gene, 34793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Pathogenicity of lupus anti-ribosomal P antibodies: role of cross-reacting neuronal surface P antigen in glutamatergic transmission and plasticity in a mouse model. Segovia-Miranda F, et al. Arthritis Rheumatol, 2015 Jun. PMID 25709106
  2. Neuronal surface P antigen (NSPA) modulates postsynaptic NMDAR stability through ubiquitination of tyrosine phosphatase PTPMEG. Espinoza S, et al. BMC Biol, 2020 Nov 6. PMID 33158444, Free PMC Article
  3. Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. Sundberg JP, et al. PLoS One, 2017. PMID 28700664, Free PMC Article
  4. Decreased expression levels of Ifi genes is associated to the increased resistance to spontaneous arthritis disease in mice deficiency of IL-1RA. Liu X, et al. BMC Immunol, 2016 Aug 2. PMID 27480124, Free PMC Article
  5. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (3) 

General gene information

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Markers

Homology

Clone Names

  • MGC107545

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables lysine-acetylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methylated histone binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein ubiquitination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within synaptic transmission, glutamatergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within visual learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
located_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger ZZ-type and EF-hand domain-containing protein 1
Names
KIAA0399-like protein human
neuronal superface P antigen

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001045536.2 → NP_001039001.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL663082
    Consensus CDS
    CCDS36218.1
    UniProtKB/TrEMBL
    E9Q5W5
    Related
    ENSMUSP00000068790.6, ENSMUST00000069395.7
    Conserved Domains (5) summary
    cd08667
    Location:250 → 380
    APC10-ZZEF1; APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
    cd00051
    Location:94 → 141
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd02249
    Location:1828 → 1875
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd02343
    Location:1779 → 1826
    ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    cl00049
    Location:1119 → 1189
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. NM_001427298.1 → NP_001414227.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL663082

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    72686976..72817946
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532601.4 → XP_006532664.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A140LJ04, E9Q5W5
    Related
    ENSMUSP00000147028.2, ENSMUST00000207107.2
    Conserved Domains (5) summary
    cd08667
    Location:250 → 380
    APC10-ZZEF1; APC10/DOC1-like domain of uncharacterized Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) and homologs
    cd00051
    Location:94 → 141
    EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...
    cd02249
    Location:1828 → 1875
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd02343
    Location:1779 → 1826
    ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    cl00049
    Location:1119 → 1189
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.

  2. XM_030245704.2 → XP_030101564.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X5

    Conserved Domains (2) summary
    cd02249
    Location:444 → 491
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd02343
    Location:395 → 442
    ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

  3. XM_011248827.3 → XP_011247129.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X3

    Conserved Domains (2) summary
    cd02249
    Location:590 → 637
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd02343
    Location:541 → 588
    ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

  4. XM_006532603.4 → XP_006532666.1  zinc finger ZZ-type and EF-hand domain-containing protein 1 isoform X4

    Conserved Domains (2) summary
    cd02249
    Location:444 → 491
    ZZ; Zinc finger, ZZ type. Zinc finger present in dystrophin, CBP/p300 and many other proteins. The ZZ motif coordinates one or two zinc ions and most likely participates in ligand binding or molecular scaffolding. Many proteins containing ZZ motifs have ...
    cd02343
    Location:395 → 442
    ZZ_EF; Zinc finger, ZZ type. Zinc finger present in proteins with an EF_hand motif. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SSH7.2 GenPept UniProtKB/Swiss-Prot:Q5SSH7

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