Klf11 Kruppel-like transcription factor 11 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klf11provided by MGI
Official Full Name: Kruppel-like transcription factor 11provided by MGI
Primary source: MGI:MGI:2653368
See related: Ensembl:ENSMUSG00000020653 AllianceGenome:MGI:2653368
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tieg2; Tieg3; Tieg2b; 9830142A17; D12Ertd427e
Summary: Enables DNA-binding transcription factor activity. Involved in negative regulation of transcription, DNA-templated. Predicted to be located in cytosol; focal adhesion; and nuclear body. Is expressed in several structures, including brain; early conceptus; genitourinary system; liver; and sensory organ. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 7 and type 2 diabetes mellitus. Orthologous to human KLF11 (Kruppel like factor 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in lung adult (RPKM 9.8), ovary adult (RPKM 9.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.3; 12 8.49 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (24701370..24712781)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (24651371..24662782)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.
Title: Host immunity and KLF 11 deficiency together promote fibrosis in a mouse model of endometriosis.
Genetic deletion of Kruppel-like factor 11 aggravates traumatic brain injury.
Title: Genetic deletion of Krüppel-like factor 11 aggravates traumatic brain injury.
KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.
Title: KLF11 deficiency enhances chemokine generation and fibrosis in murine unilateral ureteral obstruction.
Endothelium-targeted overexpression of Kruppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.
Title: Endothelium-targeted overexpression of Krüppel-like factor 11 protects the blood-brain barrier function after ischemic brain injury.
Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFbeta inducible early gene-1 knockout female mice.
Title: Sclerostin antibody treatment rescues the osteopenic bone phenotype of TGFβ inducible early gene-1 knockout female mice.
Vascular smooth muscle cell-specific Klf11 knockout mice exhibited significantly reduced occlusion time.KLF11 is a novel transcriptional suppressor of F3 in vascular smooth muscle cells. KLF11 downregulates F3 at the transcriptional level as determined by reporter and chromatin immunoprecipitation assays.
Title: KLF11 (Krüppel-Like Factor 11) Inhibits Arterial Thrombosis via Suppression of Tissue Factor in the Vascular Wall.
KLF11 acts as a novel protective factor in ischemic stroke.
Title: Genetic Deletion of Krüppel-Like Factor 11 Aggravates Ischemic Brain Injury.
Consistent with loss of Klf11-mediated activation, lesions in Klf11-/- animals were associated with progressive fibrosis and decreased Drd2 expression.
Title: KLF11 is an Epigenetic Mediator of DRD2/Dopaminergic Signaling in Endometriosis.
Using a sterile peritonitis model, fibrosis selectively developed in Klf11-/- females. Fibrosis in these animals was almost completely abrogated by ovariectomy. Ovariectomized animals were selectively supplemented with estradiol, medroxyprogesterone acetate (MPA), or dihydrotestosterone; fibrosis was only observed in mice exposed to MPA.
Title: Progressive Fibrosis: A Progesterone- and KLF11-Mediated Sexually Dimorphic Female Response.
TGFbeta and KLF11 mediate critical, translationally relevant host and lesion-driven responses that enable establishment and progression of endometriosis.
Title: TGF-β Induces Endometriotic Progression via a Noncanonical, KLF11-Mediated Mechanism.

Submit: New GeneRIF Correction See all GeneRIFs (26)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (3) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:236818

RH127237 (e-PCR)
- UniSTS:167087

C85840 (e-PCR)
- UniSTS:160192

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
NOT acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: Krueppel-like factor 11

Names: Kruppel-like factor 11; TGFB inducible early growth response 2; TGFB inducible early growth response 3; TGFB-inducible early growth response protein 2b; TGFB-inducible early growth response protein 3; TIEG-3; transforming growth factor-beta-inducible early growth response protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_178357.3 → NP_848134.1 Krueppel-like factor 11

See identical proteins and their annotated locations for NP_848134.1

Status: VALIDATED

Source sequence(s)

AK038397, DV654709

Consensus CDS

CCDS25842.1

UniProtKB/Swiss-Prot

Q8BHJ1, Q8BI37, Q8BI70, Q8K1S5

Related

ENSMUSP00000020982.6, ENSMUST00000020982.7

Conserved Domains (4) summary

COG5048
Location:382 → 439

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:389 → 408

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:444 → 466

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:430 → 453

zf-H2C2_2; Zinc-finger double domain