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Tet3 tet methylcytosine dioxygenase 3 [ Mus musculus (house mouse) ]

Gene ID: 194388, updated on 9-May-2024

Summary

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Official Symbol
Tet3provided by MGI
Official Full Name
tet methylcytosine dioxygenase 3provided by MGI
Primary source
MGI:MGI:2446229
See related
Ensembl:ENSMUSG00000034832 AllianceGenome:MGI:2446229
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B430006D22Rik; D230004J03Rik
Summary
Enables methylcytosine dioxygenase activity. Involved in DNA demethylation of male pronucleus. Acts upstream of or within DNA demethylation. Located in cytoplasm; female pronucleus; and male pronucleus. Is expressed in several structures, including central nervous system; early conceptus; future brain; and genitourinary system. Orthologous to human TET3 (tet methylcytosine dioxygenase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 8.4), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 C3; 6 35.94 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83339355..83434190, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83362373..83457208, complement)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6448 Neighboring gene STARR-seq mESC enhancer starr_16463 Neighboring gene MOB kinase activator 1A Neighboring gene bolA family member 3 Neighboring gene microRNA 6374 Neighboring gene STARR-positive B cell enhancer ABC_E4837 Neighboring gene RIKEN cDNA B230319C09 gene Neighboring gene STARR-seq mESC enhancer starr_16466 Neighboring gene deoxyguanosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1066 Neighboring gene actin, gamma 2, smooth muscle, enteric

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Role of DNA dioxygenase Ten-Eleven translocation 3 (TET3) in rheumatoid arthritis progression. Kawabe A, et al. Arthritis Res Ther, 2022 Sep 16. PMID 36114544, Free PMC Article
  2. Tet3 Deletion in Adult Brain Neurons of Female Mice Results in Anxiety-like Behavior and Cognitive Impairments. Antunes C, et al. Mol Neurobiol, 2022 Aug. PMID 35665901
  3. Deficiency of Tet3 in nucleus accumbens enhances fear generalization and anxiety-like behaviors in mice. Fan BF, et al. Brain Pathol, 2022 Nov. PMID 35612904, Free PMC Article
  4. TET3 regulates DNA hydroxymethylation of neuroprotective genes following focal ischemia. Morris-Blanco KC, et al. J Cereb Blood Flow Metab, 2021 Mar. PMID 32380888, Free PMC Article
  5. Tet3 ablation in adult brain neurons increases anxiety-like behavior and regulates cognitive function in mice. Antunes C, et al. Mol Psychiatry, 2021 May. PMID 32103150

See all (127) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation.
    Title: TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation.
  2. Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis.
    Title: Ten-eleven translocation (Tet) methylcytosine dioxygenase-dependent viral DNA demethylation mediates in vivo hepatitis B virus (HBV) biosynthesis.
  3. Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1alpha.
    Title: Skeletal muscle TET3 promotes insulin resistance through destabilisation of PGC-1α.
  4. TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells.
    Title: TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells.
  5. Inhibition of myocardial remodeling through miR-150/TET3 axis after AMI.
    Title: Inhibition of myocardial remodeling through miR-150/TET3 axis after AMI.
  6. TET3 plays a critical role in white adipose development and diet-induced remodeling.
    Title: TET3 plays a critical role in white adipose development and diet-induced remodeling.
  7. TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors.
    Title: TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors.
  8. Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons.
    Title: Circadian clock regulator Bmal1 gates axon regeneration via Tet3 epigenetics in mouse sensory neurons.
  9. TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.
    Title: TET2 and TET3 loss disrupts small intestine differentiation and homeostasis.
  10. miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression.
    Title: miR-488-5p mitigates hepatic stellate cell activation and hepatic fibrosis via suppressing TET3 expression.
Submit: New GeneRIF Correction See all GeneRIFs (71)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (12)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 5-methylcytosine dioxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 5-methylcytosine dioxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables 5-methylcytosine dioxygenase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables dioxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables methyl-CpG binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in 5-methylcytosine catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA demethylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within DNA demethylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in epigenetic programing of male pronucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in protein O-linked glycosylation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in female pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in male pronucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
methylcytosine dioxygenase TET3
Names
probable methylcytosine dioxygenase TET3
tet oncogene family member 3
NP_001334242.1
NP_898961.2
XP_006505838.1
XP_006505839.1
XP_006505840.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347313.1 → NP_001334242.1  methylcytosine dioxygenase TET3 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC090648, AC159713
    Consensus CDS
    CCDS85071.1
    UniProtKB/Swiss-Prot
    K9JH93, L0HN04, Q4VAD3, Q8BG87, Q8C8N8, Q8CI60
    Related
    ENSMUSP00000139630.2, ENSMUST00000186548.7
    Conserved Domains (4) summary
    PHA03247
    Location:297 → 760
    PHA03247; large tegument protein UL36; Provisional
    pfam02008
    Location:50 → 89
    zf-CXXC; CXXC zinc finger domain
    cd18897
    Location:836 → 1160
    TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
    cl40427
    Location:1612 → 1774
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

  2. NM_183138.2 → NP_898961.2  methylcytosine dioxygenase TET3 isoform 2

    See identical proteins and their annotated locations for NP_898961.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks multiple exons in the coding region, and uses an in-frame downstream start codon, compared to variant 1. Variant 2 encodes a protein (isoform 2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC090648, AC159713
    Consensus CDS
    CCDS51820.1
    UniProtKB/TrEMBL
    A0A5K1VVP6
    Related
    ENSMUSP00000087049.5, ENSMUST00000089622.11
    Conserved Domains (1) summary
    pfam12851
    Location:858 → 985
    Tet_JBP; Oxygenase domain of the 2OGFeDO superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    83339355..83434190 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006505776.4 → XP_006505839.1  methylcytosine dioxygenase TET3 isoform X1

    See identical proteins and their annotated locations for XP_006505839.1

    UniProtKB/Swiss-Prot
    K9JH93, L0HN04, Q4VAD3, Q8BG87, Q8C8N8, Q8CI60
    Conserved Domains (4) summary
    PHA03247
    Location:297 → 760
    PHA03247; large tegument protein UL36; Provisional
    pfam02008
    Location:50 → 89
    zf-CXXC; CXXC zinc finger domain
    cd18897
    Location:836 → 1160
    TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
    cl40427
    Location:1612 → 1774
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

  2. XM_006505775.4 → XP_006505838.1  methylcytosine dioxygenase TET3 isoform X1

    See identical proteins and their annotated locations for XP_006505838.1

    UniProtKB/Swiss-Prot
    K9JH93, L0HN04, Q4VAD3, Q8BG87, Q8C8N8, Q8CI60
    Conserved Domains (4) summary
    PHA03247
    Location:297 → 760
    PHA03247; large tegument protein UL36; Provisional
    pfam02008
    Location:50 → 89
    zf-CXXC; CXXC zinc finger domain
    cd18897
    Location:836 → 1160
    TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
    cl40427
    Location:1612 → 1774
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins

  3. XM_006505777.4 → XP_006505840.1  methylcytosine dioxygenase TET3 isoform X2

    See identical proteins and their annotated locations for XP_006505840.1

    UniProtKB/TrEMBL
    K9JH93
    Conserved Domains (4) summary
    PHA03247
    Location:278 → 741
    PHA03247; large tegument protein UL36; Provisional
    pfam02008
    Location:50 → 89
    zf-CXXC; CXXC zinc finger domain
    cd18897
    Location:817 → 1141
    TET3; oxygenase domain of ten-eleven translocation (TET)3 methylcytosine dioxygenase and similar proteins
    cl40427
    Location:1593 → 1755
    Tet_JBP; oxygenase domain of ten-eleven translocation (TET) enzymes, J-binding proteins (JBPs), and similar proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BG87.4 GenPept UniProtKB/Swiss-Prot:Q8BG87

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