Rasl2-9 RAS-like, family 2, locus 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rasl2-9provided by MGI
Official Full Name: RAS-like, family 2, locus 9provided by MGI
Primary source: MGI:MGI:104605
See related: Ensembl:ENSMUSG00000083649 AllianceGenome:MGI:104605
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: M2; Ran; Ran/M2; Rasl2-9-ps
Summary: Predicted to enable several functions, including guanyl ribonucleotide binding activity; magnesium ion binding activity; and protein heterodimerization activity. Predicted to contribute to pre-miRNA binding activity. Predicted to be involved in several processes, including nucleocytoplasmic transport; positive regulation of protein import into nucleus; and protein localization to nucleolus. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including centriole; midbody; and nucleus. Predicted to be part of RNA nuclear export complex. Predicted to be active in cytoplasm and nucleus. Predicted to colocalize with chromatin. Is expressed in cerebral cortex ventricular layer. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 7 A1; 7 2.96 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (5127941..5128949, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (5124942..5125950, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: GTP-binding nuclear protein Ran, testis-specific isoform

Names: RAS-like, family 2, locus 9, pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009028.2 → NP_033054.1 GTP-binding nuclear protein Ran, testis-specific isoform

See identical proteins and their annotated locations for NP_033054.1

Status: VALIDATED

Source sequence(s)

BC099553

Consensus CDS

CCDS20760.1

UniProtKB/Swiss-Prot

Q4FZF4, Q61820, Q6P8M7, Q80YD4, Q9D9Y0

UniProtKB/TrEMBL

A6H622, Q3ULW0

Related

ENSMUSP00000129559.2, ENSMUST00000147835.4

Conserved Domains (2) summary

smart00176
Location:16 → 215

RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases

cd00877
Location:11 → 176

Ran; Ras-related nuclear proteins (Ran)/TC4 family of small GTPases