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Airim AFG2 interacting ribosome maturation factor [ Mus musculus (house mouse) ]

Gene ID: 194268, updated on 5-Mar-2024

Summary

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Official Symbol
Airimprovided by MGI
Official Full Name
AFG2 interacting ribosome maturation factorprovided by MGI
Primary source
MGI:MGI:3041172
See related
Ensembl:ENSMUSG00000044730 AllianceGenome:MGI:3041172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C1orf109; 9930104L06Rik
Summary
Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm and nucleus. Orthologous to human C1orf109 (chromosome 1 open reading frame 109). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 5.8), limb E14.5 (RPKM 5.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.94 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124830777..124838454)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124936984..124944661)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700125G02 gene Neighboring gene Eph receptor A10 Neighboring gene cell division cycle associated 8 Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene predicted gene 12930 Neighboring gene predicted gene, 32371 Neighboring gene R-spondin 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article
  2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC107426

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in ribosomal large subunit biogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ribosome biogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
AFG2-interacting ribosome maturation factor
Names
ribosome biogenesis protein C1orf109 homolog
uncharacterized protein C1orf109 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001355603.1 → NP_001342532.1  AFG2-interacting ribosome maturation factor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK037053, AK158126, AL606933, BY781867
    Consensus CDS
    CCDS89826.1
    UniProtKB/Swiss-Prot
    Q148T1, Q3TU44, Q499E6, Q8BI05
    Conserved Domains (1) summary
    pfam15011
    Location:13 → 167
    CK2S; Casein Kinase 2 substrate

  2. NM_001355605.1 → NP_001342534.1  AFG2-interacting ribosome maturation factor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK037053, AK158126, AL606933, BY781867
    Consensus CDS
    CCDS89826.1
    UniProtKB/Swiss-Prot
    Q148T1, Q3TU44, Q499E6, Q8BI05
    Conserved Domains (1) summary
    pfam15011
    Location:13 → 167
    CK2S; Casein Kinase 2 substrate

  3. NM_177573.3 → NP_808241.2  AFG2-interacting ribosome maturation factor

    See identical proteins and their annotated locations for NP_808241.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK158126, AL606933
    Consensus CDS
    CCDS89826.1
    UniProtKB/Swiss-Prot
    Q148T1, Q3TU44, Q499E6, Q8BI05
    Related
    ENSMUSP00000154851.2, ENSMUST00000094769.13
    Conserved Domains (1) summary
    pfam15011
    Location:13 → 167
    CK2S; Casein Kinase 2 substrate

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124830777..124838454
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502884.4 → XP_006502947.1  AFG2-interacting ribosome maturation factor isoform X1

    See identical proteins and their annotated locations for XP_006502947.1

    Conserved Domains (1) summary
    pfam15011
    Location:13 → 167
    CK2S; Casein Kinase 2 substrate

  2. XM_006502885.3 → XP_006502948.1  AFG2-interacting ribosome maturation factor isoform X1

    See identical proteins and their annotated locations for XP_006502948.1

    Conserved Domains (1) summary
    pfam15011
    Location:13 → 167
    CK2S; Casein Kinase 2 substrate
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q499E6.1 GenPept UniProtKB/Swiss-Prot:Q499E6

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