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Cnksr1 connector enhancer of kinase suppressor of Ras 1 [ Mus musculus (house mouse) ]

Gene ID: 194231, updated on 5-Mar-2024

Summary

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Official Symbol
Cnksr1provided by MGI
Official Full Name
connector enhancer of kinase suppressor of Ras 1provided by MGI
Primary source
MGI:MGI:2670958
See related
Ensembl:ENSMUSG00000028841 AllianceGenome:MGI:2670958
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable protein-macromolecule adaptor activity. Predicted to act upstream of or within Rho protein signal transduction. Predicted to be located in cell cortex. Orthologous to human CNKSR1 (connector enhancer of kinase suppressor of Ras 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 14.7), colon adult (RPKM 13.4) and 14 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.3; 4 66.5 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (133955352..133965737, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134228041..134238416, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene zona pellucida like domain containing 2 Neighboring gene cation channel, sperm associated 4 Neighboring gene STARR-positive B cell enhancer ABC_E7997 Neighboring gene Zfp593 opposite strand Neighboring gene zinc finger protein 593 Neighboring gene predicted gene, 30191

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
  2. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
  3. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
  4. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
  5. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein-macromolecule adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Ras protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell cortex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
connector enhancer of kinase suppressor of ras 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081047.1 → NP_001074516.1  connector enhancer of kinase suppressor of ras 1

    Status: PROVISIONAL

    Source sequence(s)
    AL627314
    Consensus CDS
    CCDS38912.1
    UniProtKB/TrEMBL
    A2A9K7, Q14CF7
    Related
    ENSMUSP00000030645.9, ENSMUST00000030645.9
    Conserved Domains (6) summary
    smart00454
    Location:4 → 69
    SAM; Sterile alpha motif
    cd00992
    Location:205 → 273
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01260
    Location:376 → 489
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
    pfam00169
    Location:390 → 486
    PH; PH domain
    pfam10534
    Location:78 → 162
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl15755
    Location:4 → 70
    SAM_superfamily; SAM (Sterile alpha motif )

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    133955352..133965737 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011250217.1 → XP_011248519.1  connector enhancer of kinase suppressor of ras 1 isoform X1

    Conserved Domains (1) summary
    cd01260
    Location:75 → 188
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

  2. XM_011250218.4 → XP_011248520.1  connector enhancer of kinase suppressor of ras 1 isoform X2

    Conserved Domains (3) summary
    cd00992
    Location:205 → 273
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam10534
    Location:78 → 162
    CRIC_ras_sig; Connector enhancer of kinase suppressor of ras
    cl15755
    Location:4 → 70
    SAM_superfamily; SAM (Sterile alpha motif )
Nucleotide Protein Strain
Heading Accession and Version

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