Ran RAN, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ranprovided by MGI
Official Full Name: RAN, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1333112
See related: Ensembl:ENSMUSG00000029430 AllianceGenome:MGI:1333112
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within actin cytoskeleton organization; protein import into nucleus; and protein-containing complex localization. Located in cytoplasm and nuclear envelope. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 161.6), liver E14 (RPKM 152.8) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 G1.3; 5 67.99 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (129097264..129101388)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (129020156..129024322)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data support that Ran GTPase-dependent and independent and moonlighting roles of Ranbp2 or domains thereof and ubc9 control selectively age-dependent, neural-type and mitochondrial functions
Title: Impairments in age-dependent ubiquitin proteostasis and structural integrity of selective neurons by uncoupling Ran GTPase from the Ran-binding domain 3 of Ranbp2 and identification of novel mitochondrial isoforms of ubiquitin-conjugating enzyme E2I (ubc9) and Ranbp2.
Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite, and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched.
Title: Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.
Data suggest Ran activation by RanBP1 in macrophages promotes Legionella phagosome formation and phagocytosis; LegG1 functions as bacterial Ran activator, localizes to phagosomes, and promotes microtubule stabilization, phagocytosis, and replication.
Title: Activation of Ran GTPase by a Legionella effector promotes microtubule polymerization, pathogen vacuole motility and infection.
Augmented expression of Ran in progranulin-deficient neurons restores nuclear TDP-43 levels and improves their survival.
Title: Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.
Reduction in Ran levels causes cytoplasmic decrease and nuclear accumulation of importin alpha leading to cellular senescence in normal cells.
Title: Downregulation of the small GTPase ras-related nuclear protein accelerates cellular ageing.
a novel connection between the hyper-activation of the small GTPase Ran and the matricellular protein SMOC-2 that has important consequences for oncogenic transformation.
Title: Characterization of a novel activated Ran GTPase mutant and its ability to induce cellular transformation.
A critical function of RanBP2 is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.
Title: Ran-dependent docking of importin-beta to RanBP2/Nup358 filaments is essential for protein import and cell viability.
Downregulation of the Ran GTPase effector RanBP1 is required for nuclear reorganisation.
Title: Nuclear reformation after mitosis requires downregulation of the Ran GTPase effector RanBP1 in mammalian cells.
intracellular Ran protein levels controlled the nuclear presence of certain transcription factors
Title: Reduced Ran expression in Ran(+/-) fibroblasts increases cytokine-stimulated nuclear abundance of the AP-1 subunits c-Fos and c-Jun.
intracellular Ran protein levels control the nuclear retention for selective transcription factors such as c-Jun and c-Fos of AP-1, which is known to be critical in T cell activation and proliferation and lymphokine secretion.
Title: Ran overexpression leads to diminished T cell responses and selectively modulates nuclear levels of c-Jun and c-Fos.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	ISO Inferred from Sequence Orthology more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables dynein intermediate chain binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables importin-alpha family protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
contributes_to pre-miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in GTP metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid segregation	ISO Inferred from Sequence Orthology more info
involved_in nucleocytoplasmic transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein import into nucleus	IDA Inferred from Direct Assay more info	PubMed
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to nucleolus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein-containing complex localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal large subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit export from nucleus	ISO Inferred from Sequence Orthology more info
involved_in ribosomal subunit export from nucleus	IBA Inferred from Biological aspect of Ancestor more info
involved_in snRNA import into nucleus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA nuclear export complex	ISO Inferred from Sequence Orthology more info
located_in centriole	ISO Inferred from Sequence Orthology more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in male germ cell nucleus	ISO Inferred from Sequence Orthology more info
located_in manchette	ISO Inferred from Sequence Orthology more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in sperm flagellum	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: GTP-binding nuclear protein Ran

Names: GTPase Ran; ras-like protein TC4; ras-related nuclear protein

NP_001408127.1

EC 3.6.5.-

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NP_033417.1

EC 3.6.5.-

EC 3.6.5.1

EC 3.6.5.2

EC 3.6.5.3

EC 3.6.5.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001421198.1 → NP_001408127.1 GTP-binding nuclear protein Ran

Status: VALIDATED

Source sequence(s)

AC110566

UniProtKB/Swiss-Prot

P62827, Q3U954, Q811M2
NM_009391.4 → NP_033417.1 GTP-binding nuclear protein Ran

See identical proteins and their annotated locations for NP_033417.1

Status: VALIDATED

Source sequence(s)

AC110566

Consensus CDS

CCDS19693.1

UniProtKB/Swiss-Prot

P62827, Q3U954, Q811M2

UniProtKB/TrEMBL

Q3ULW0

Related

ENSMUSP00000031383.8, ENSMUST00000031383.14

Conserved Domains (1) summary

smart00176
Location:16 → 215

RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases