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Rad1 RAD1 checkpoint DNA exonuclease [ Mus musculus (house mouse) ]

Gene ID: 19355, updated on 11-Apr-2024

Summary

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Official Symbol
Rad1provided by MGI
Official Full Name
RAD1 checkpoint DNA exonucleaseprovided by MGI
Primary source
MGI:MGI:1316678
See related
Ensembl:ENSMUSG00000022248 AllianceGenome:MGI:1316678
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mRAD1
Summary
Predicted to enable 3'-5' exonuclease activity. Predicted to be involved in DNA repair; cellular response to ionizing radiation; and negative regulation of cell cycle phase transition. Predicted to act upstream of or within cellular response to DNA damage stimulus. Predicted to be located in chromosome and nucleoplasm. Predicted to be part of checkpoint clamp complex. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and hemolymphoid system gland. Orthologous to human RAD1 (RAD1 checkpoint DNA exonuclease). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 3.3), liver E14 (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rad1 in Genome Data Viewer
Location:
15 A1; 15 5.35 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10486104..10499149)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10486018..10499063)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene DnaJ heat shock protein family (Hsp40) member C21 Neighboring gene STARR-positive B cell enhancer ABC_E9414 Neighboring gene STARR-seq mESC enhancer starr_37954 Neighboring gene BRX1, biogenesis of ribosomes Neighboring gene tetratricopeptide repeat domain 23-like Neighboring gene STARR-seq mESC enhancer starr_37955 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene retinoic acid induced 14 Neighboring gene predicted gene 10389

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses. Zhang C, et al. Protein Cell, 2011 May. PMID 21637962, Free PMC Article
  2. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Han L, et al. Mol Cancer, 2010 Mar 24. PMID 20334655, Free PMC Article
  3. A human and mouse homolog of the Schizosaccharomyces pombe rad1+ cell cycle checkpoint control gene. Bluyssen HA, et al. Genomics, 1998 Dec 1. PMID 9828137
  4. Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA. Wit N, et al. PLoS One, 2011 Jan 31. PMID 21304913, Free PMC Article
  5. HRAD1 and MRAD1 encode mammalian homologues of the fission yeast rad1(+) cell cycle checkpoint control gene. Udell CM, et al. Nucleic Acids Res, 1998 Sep 1. PMID 9705507, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HUS1 acts as a component of the canonical 9-1-1 complex during meiotic prophase I to promote DSB repair and further propose that RAD1 and TOPBP1 respond to unsynapsed chromatin through an alternative mechanism that does not require RAD9 or HUS1.
    Title: Conditional inactivation of the DNA damage response gene Hus1 in mouse testis reveals separable roles for components of the RAD9-RAD1-HUS1 complex in meiotic chromosome maintenance.
  2. The rad1 protein is required for repairing DNA lesions induced by UV-light, HU and gamma rays, and for mediating G(2)/M and S/M checkpoint controls.
    Title: Targeted deletion of mouse Rad1 leads to deficient cellular DNA damage responses.
  3. data indicate that Rad1(K185) is not a functional counterpart of PCNA(K164).
    Title: Lysine residue 185 of Rad1 is a topological but not a functional counterpart of lysine residue 164 of PCNA.
  4. data suggest that Mrad1 is important for preventing tumor development.
    Title: Mouse Rad1 deletion enhances susceptibility for skin tumor development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in DNA damage checkpoint signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to ionizing radiation ISO
Inferred from Sequence Orthology
more info
  
involved_in meiotic recombination checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of checkpoint clamp complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of checkpoint clamp complex ISO
Inferred from Sequence Orthology
more info
  
located_in chromosome ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cell cycle checkpoint protein RAD1
Names
DNA repair exonuclease rad1 homolog
RAD1 homolog
rad1-like DNA damage checkpoint protein
NP_001276376.1
NP_001276377.1
NP_001398639.1
NP_035362.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289447.2 → NP_001276376.1  cell cycle checkpoint protein RAD1

    See identical proteins and their annotated locations for NP_001276376.1

    Status: VALIDATED

    Source sequence(s)
    AC102101
    Consensus CDS
    CCDS27379.1
    UniProtKB/Swiss-Prot
    O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3
    Conserved Domains (1) summary
    pfam02144
    Location:17 → 257
    Rad1; Repair protein Rad1/Rec1/Rad17

  2. NM_001289448.1 → NP_001276377.1  cell cycle checkpoint protein RAD1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC102101, AK168588
    Consensus CDS
    CCDS70618.1
    UniProtKB/Swiss-Prot
    Q9QWZ1
    Related
    ENSMUSP00000098338.4, ENSMUST00000100775.10
    Conserved Domains (2) summary
    cd00577
    Location:19 → 228
    PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...
    pfam02144
    Location:17 → 222
    Rad1; Repair protein Rad1/Rec1/Rad17

  3. NM_001411710.1 → NP_001398639.1  cell cycle checkpoint protein RAD1

    Status: VALIDATED

    Source sequence(s)
    AC102101
    UniProtKB/Swiss-Prot
    O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3

  4. NM_011232.4 → NP_035362.2  cell cycle checkpoint protein RAD1

    See identical proteins and their annotated locations for NP_035362.2

    Status: VALIDATED

    Source sequence(s)
    AC102101
    Consensus CDS
    CCDS27379.1
    UniProtKB/Swiss-Prot
    O70452, O88391, Q3TGU1, Q3UG66, Q9QWZ1, Q9QWZ3
    Related
    ENSMUSP00000022856.9, ENSMUST00000022856.15
    Conserved Domains (1) summary
    pfam02144
    Location:17 → 257
    Rad1; Repair protein Rad1/Rec1/Rad17

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10486104..10499149
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9QWZ1.1 GenPept UniProtKB/Swiss-Prot:Q9QWZ1

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