Rac1 Rac family small GTPase 1 [ Mus musculus (house mouse) ]

Gene ID: 19353, updated on 11-Apr-2024

Summary

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Official Symbol: Rac1provided by MGI
Official Full Name: Rac family small GTPase 1provided by MGI
Primary source: MGI:MGI:97845
See related: Ensembl:ENSMUSG00000001847 AllianceGenome:MGI:97845
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D5Ertd559e
Summary: Enables GTP binding activity; GTP-dependent protein binding activity; and GTPase activity. Involved in several processes, including engulfment of apoptotic cell; nervous system development; and regulation of cell migration. Acts upstream of or within several processes, including cell morphogenesis involved in differentiation; cochlea morphogenesis; and neuron differentiation. Located in several cellular components, including kinocilium; pericentriolar material; and ruffle membrane. Is extrinsic component of plasma membrane. Is expressed in several structures, including central nervous system; early conceptus; embryo mesoderm; eye; and genitourinary system. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 48; colon adenocarcinoma; and pancreatic adenocarcinoma. Orthologous to human RAC1 (Rac family small GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in colon adult (RPKM 163.9), small intestine adult (RPKM 137.6) and 28 other tissues See more
Orthologs: human all
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Genomic context

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See Rac1 in Genome Data Viewer

Location:: 5 G2; 5 82.22 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (143491236..143513786, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (143505481..143528031, complement)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332.
Title: Subpopulation commensalism promotes Rac1-dependent invasion of single cells via laminin-332.
Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
Title: Differential Role of the RAC1-Binding Proteins FAM49b (CYRI-B) and CYFIP1 in Platelets.
Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.
Title: Angiotensin II acts through Rac1 to upregulate pendrin: role of NADPH oxidase.
Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity.
Title: Cell aggregation activates small GTPase Rac1 and induces CD44 cleavage by maintaining lipid raft integrity.
Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury.
Title: Conditional Astrocyte Rac1KO Attenuates Hyperreflexia after Spinal Cord Injury.
Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy.
Title: Palmitoylation-dependent regulation of cardiomyocyte Rac1 signaling activity and minor effects on cardiac hypertrophy.
The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
Title: The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes.
Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Title: Gas6 Promotes Microglia Efferocytosis and Suppresses Inflammation Through Activating Axl/Rac1 Signaling in Subarachnoid Hemorrhage Mice.
Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
Title: Impaired Insulin Signaling Mediated by the Small GTPase Rac1 in Skeletal Muscle of the Leptin-Deficient Obese Mouse.
The Evaluation of Rac1 Signaling as a Potential Therapeutic Target of Alzheimer's Disease.
Title: The Evaluation of Rac1 Signaling as a Potential Therapeutic Target of Alzheimer's Disease.

Submit: New GeneRIF Correction See all GeneRIFs (552)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (9) 1 citation
Endonuclease-mediated (6)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D5Ertd559e (e-PCR), detects polymorphism
- UniSTS:167446

RH125402 (e-PCR)
- UniSTS:162224

Rac1 (e-PCR), detects polymorphism
- UniSTS:256448

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables G protein activity	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info	PubMed
enables GTP-dependent protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables GTPase activity	ISO Inferred from Sequence Orthology more info	PubMed
enables Rho GDP-dissociation inhibitor binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables histone deacetylase binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables thioesterase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Rac protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in Rac protein signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in Rac protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin filament organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within anatomical structure arrangement	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within angiotensin-activated signaling pathway involved in heart process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within auditory receptor cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone resorption	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell chemotaxis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IDA Inferred from Direct Assay more info	PubMed
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell motility	ISO Inferred from Sequence Orthology more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell junction organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to mechanical stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cerebral cortex GABAergic interneuron development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cerebral cortex radially oriented cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cochlea morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cortical cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendrite development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within dopaminergic neuron differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic olfactory bulb interneuron precursor migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in engulfment of apoptotic cell	IBA Inferred from Biological aspect of Ancestor more info
involved_in engulfment of apoptotic cell	IDA Inferred from Direct Assay more info	PubMed
involved_in enzyme-linked receptor protein signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within epithelial cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within erythrocyte enucleation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IBA Inferred from Biological aspect of Ancestor more info
involved_in forebrain development	IDA Inferred from Direct Assay more info	PubMed
involved_in hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostasis of number of cells within a tissue	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hyperosmotic response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within interneuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lamellipodium assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lamellipodium assembly	TAS Traceable Author Statement more info	PubMed
involved_in localization	ISO Inferred from Sequence Orthology more info
involved_in localization within membrane	ISO Inferred from Sequence Orthology more info
involved_in mast cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in midbrain dopaminergic neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-23 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in non-canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA replication	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of actin filament polymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of dendritic spine development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of dendritic spine development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of filopodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neutrophil chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neutrophil chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovarian follicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of skeletal muscle acetylcholine-gated channel clustering	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
involved_in postsynaptic actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to plasma membrane	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of ERK5 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of actin cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell adhesion involved in heart morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of cell morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of lamellipodium assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neuron maturation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of neuronal synaptic plasticity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neutrophil migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of receptor signaling pathway via JAK-STAT	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of respiratory burst	ISO Inferred from Sequence Orthology more info
involved_in regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in regulation of synaptic vesicle endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic vesicle endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in ruffle assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within ruffle organization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in semaphorin-plexin signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within small GTPase-mediated signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in small GTPase-mediated signal transduction	ISO Inferred from Sequence Orthology more info
involved_in sphingosine-1-phosphate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within substrate adhesion-dependent cell spreading	IDA Inferred from Direct Assay more info	PubMed
involved_in substrate adhesion-dependent cell spreading	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synaptic transmission, GABAergic	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	ISO Inferred from Sequence Orthology more info
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with actin filament	ISO Inferred from Sequence Orthology more info
located_in cell cortex	ISO Inferred from Sequence Orthology more info
located_in cell projection	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in dendritic spine	IBA Inferred from Biological aspect of Ancestor more info
located_in dendritic spine	ISO Inferred from Sequence Orthology more info
located_in early endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in kinocilium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in pericentriolar material	IDA Inferred from Direct Assay more info	PubMed
located_in phagocytic cup	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	IEA Inferred from Electronic Annotation more info
is_active_in synaptic vesicle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related C3 botulinum toxin substrate 1

Names: RAS-related C3 botulinum substrate 1; p21-Rac1

NP_001334459.1

EC 3.6.5.2

NP_033033.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347530.1 → NP_001334459.1 ras-related C3 botulinum toxin substrate 1 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC217112

Consensus CDS

CCDS84993.1

UniProtKB/TrEMBL

Q3TLP8, Q8BPG5, Q9D859

Related

ENSMUSP00000098058.4, ENSMUST00000100489.4
NM_009007.2 → NP_033033.1 ras-related C3 botulinum toxin substrate 1 isoform 2

See identical proteins and their annotated locations for NP_033033.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

BQ444803, CO425367, CX242948, CX566679

Consensus CDS

CCDS19843.1

UniProtKB/Swiss-Prot

P63001

UniProtKB/TrEMBL

K7Q7T7, Q8BPG5, Q9D859

Related

ENSMUSP00000079380.8, ENSMUST00000080537.14

Conserved Domains (1) summary

cd01871
Location:3 → 176

Rac1_like; Ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)-like consists of Rac1, Rac2 and Rac3