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Kif20a kinesin family member 20A [ Mus musculus (house mouse) ]

Gene ID: 19348, updated on 11-Apr-2024

Summary

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Official Symbol
Kif20aprovided by MGI
Official Full Name
kinesin family member 20Aprovided by MGI
Primary source
MGI:MGI:1201682
See related
Ensembl:ENSMUSG00000003779 AllianceGenome:MGI:1201682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rab6kifl
Summary
Predicted to enable several functions, including ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in several processes, including microtubule bundle formation; midbody abscission; and regulation of cytokinesis. Predicted to act upstream of or within protein transport. Predicted to be located in several cellular components, including cleavage furrow; intercellular bridge; and midbody. Predicted to be part of kinesin complex. Predicted to be active in microtubule and nucleus. Is expressed in 4-cell stage embryo; brain ventricular layer; genitourinary system; and stomach. Human ortholog(s) of this gene implicated in restrictive cardiomyopathy. Orthologous to human KIF20A (kinesin family member 20A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 32.7), liver E14 (RPKM 27.3) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
18 B1; 18 18.69 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (34757677..34766330)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (34624624..34633277)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene BRD8 domain containing Neighboring gene bromodomain containing 8 Neighboring gene predicted gene, 41688 Neighboring gene STARR-positive B cell enhancer ABC_E4242 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:34784160-34784348 Neighboring gene STARR-positive B cell enhancer ABC_E963 Neighboring gene STARR-seq mESC enhancer starr_44210 Neighboring gene CDC23 cell division cycle 23 Neighboring gene STARR-seq mESC enhancer starr_44211 Neighboring gene nuclear encoded rRNA 5S 25 Neighboring gene glial cell line derived neurotrophic factor family receptor alpha 3 Neighboring gene predicted gene, 52376

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Kinesin-6 family motor KIF20A regulates central spindle assembly and acrosome biogenesis in mouse spermatogenesis. She ZY, et al. Biochim Biophys Acta Mol Cell Res, 2020 Apr. PMID 31884069
  2. KIF20A mRNA and its product MKlp2 are increased during hepatocyte proliferation and hepatocarcinogenesis. Gasnereau I, et al. Am J Pathol, 2012 Jan. PMID 22056911
  3. A kinesin is present at unique sertoli/spermatid adherens junctions in rat and mouse testes. Vaid KS, et al. Biol Reprod, 2007 Dec. PMID 17855729
  4. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth. Qiu R, et al. Commun Biol, 2021 May 11. PMID 33976373, Free PMC Article
  5. SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development. Qiu R, et al. Cereb Cortex, 2020 May 14. PMID 31813992, Free PMC Article

See all (36) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
    Title: SEPT7 Interacts with KIF20A and Regulates the Proliferative State of Neural Progenitor Cells During Cortical Development.
  2. Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
    Title: Depletion of kinesin motor KIF20A to target cell fate control suppresses medulloblastoma tumour growth.
  3. KIF20A binds the microtubules to organize the central spindle assembly during spermatogenesis.
    Title: Kinesin-6 family motor KIF20A regulates central spindle assembly and acrosome biogenesis in mouse spermatogenesis.
  4. It has been reported that mitotic kinesin KIF20A interacts with RGS3 and plays a crucial role in controlling the division modes of neural progenitor cells during cortical neurogenesis.
    Title: KIF20A/MKLP2 regulates the division modes of neural progenitor cells during cortical development.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables microtubule motor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in microtubule bundle formation ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in midbody abscission ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cytokinesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cytokinesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in intercellular bridge ISO
Inferred from Sequence Orthology
more info
  
part_of kinesin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
kinesin-like protein KIF20A
Names
Rabkinesin-6
kinesin-like protein 174
rab6-interacting kinesin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166406.1 → NP_001159878.1  kinesin-like protein KIF20A

    See identical proteins and their annotated locations for NP_001159878.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variants 2 and 3 encode the same protein.
    Source sequence(s)
    AK084732, BC060608
    Consensus CDS
    CCDS29131.1
    UniProtKB/Swiss-Prot
    P97329, Q542M4
    Related
    ENSMUSP00000132659.2, ENSMUST00000166044.3
    Conserved Domains (4) summary
    cd01368
    Location:62 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:69 → 505
    Kinesin; Kinesin motor domain
    cd16269
    Location:620 → 631
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:536 → 651
    GBP_C; Guanylate-binding protein, C-terminal domain

  2. NM_001166407.1 → NP_001159879.1  kinesin-like protein KIF20A

    See identical proteins and their annotated locations for NP_001159879.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AC074335, AK084732, AK144844
    Consensus CDS
    CCDS29131.1
    UniProtKB/Swiss-Prot
    P97329, Q542M4
    Related
    ENSMUSP00000130045.2, ENSMUST00000167161.9
    Conserved Domains (4) summary
    cd01368
    Location:62 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:69 → 505
    Kinesin; Kinesin motor domain
    cd16269
    Location:620 → 631
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:536 → 651
    GBP_C; Guanylate-binding protein, C-terminal domain

  3. NM_009004.4 → NP_033030.1  kinesin-like protein KIF20A

    See identical proteins and their annotated locations for NP_033030.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR exon, as compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    AK084732, AK144844, BY012551
    Consensus CDS
    CCDS29131.1
    UniProtKB/Swiss-Prot
    P97329, Q542M4
    Related
    ENSMUSP00000157839.2, ENSMUST00000237407.2
    Conserved Domains (4) summary
    cd01368
    Location:62 → 504
    KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
    pfam00225
    Location:69 → 505
    Kinesin; Kinesin motor domain
    cd16269
    Location:620 → 631
    GBP_C; coiled coil [structural motif]
    cl20817
    Location:536 → 651
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    34757677..34766330
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97329.1 GenPept UniProtKB/Swiss-Prot:P97329

Gene LinkOut

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