Rab6a RAB6A, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab6aprovided by MGI
Official Full Name: RAB6A, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:894313
See related: Ensembl:ENSMUSG00000030704 AllianceGenome:MGI:894313
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Rab6; 2610028L11Rik
Summary: Predicted to enable several functions, including ATPase binding activity; GTP binding activity; and myosin V binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; intracellular protein transport; and protein localization to Golgi apparatus. Predicted to act upstream of or within peptidyl-cysteine methylation. Located in Golgi apparatus. Is expressed in several structures, including diaphragm; nervous system; sensory organ; and tooth. Orthologous to human RAB6A (RAB6A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in cortex adult (RPKM 77.2), CNS E18 (RPKM 68.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 E2; 7 54.36 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (100256778..100290475)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (100607575..100641268)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[Should I stay or should I go? Neural stem cell anchorage during cerebral cortex development requires the GTPase RAB6 and dynein].
Title: [Should I stay or should I go? Neural stem cell anchorage during cerebral cortex development requires the GTPase RAB6 and dynein].
ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
Title: ELKS1 Captures Rab6-Marked Vesicular Cargo in Presynaptic Nerve Terminals.
RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Title: RAB6 GTPase regulates mammary secretory function by controlling the activation of STAT5.
Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.
Title: Loss of Rab6a in the small intestine causes lipid accumulation and epithelial cell death from lactation.
LAT, once internalized, transits through the Golgi-trans-Golgi network (TGN), where it is repolarized to the immune synapse.
Title: Rab6-dependent retrograde traffic of LAT controls immune synapse formation and T cell activation.
In cultured melanocytes, the secretory route relies on RAB6 and ELKS to directly transport and dock Golgi-derived carriers to melanosomes.
Title: Routing of the RAB6 secretory pathway towards the lysosome related organelle of melanocytes.
The data reveal that Rab6a not only participates in modulating the organization of oocyte organelles, but also is a novel regulator of meiotic apparatus in mammalian oocytes.
Title: Involvement of Rab6a in organelle rearrangement and cytoskeletal organization during mouse oocyte maturation.
Rab6a knockdown in oocytes may compromise the interaction between kinetochore and microtubule, which in turn leads to the activation of spindle assembly checkpoint signal, and, as a result, chromosome misalignment and spindle defects are established during meiosis, causing the production of aneuploid eggs and persistent defects in embryos.
Title: Rab6a is a novel regulator of meiotic apparatus and maturational progression in mouse oocytes.
Our study shows that RAB6 is an essential gene required for normal embryonic development
Title: Phenotypic characterisation of RAB6A knockout mouse embryonic fibroblasts.
several analyses of vesicular transport demonstrated that Rab6A and BICD2 play crucial roles in Golgi tubule fusion with the endoplasmic reticulum (ER) in brefeldin A (BFA)-treated cells
Title: Reconstitution of the targeting of Rab6A to the Golgi apparatus in semi-intact HeLa cells: A role of BICD2 in stabilizing Rab6A on Golgi membranes and a concerted role of Rab6A/BICD2 interactions in Golgi-to-ER retrograde transport.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH124272 (e-PCR)
- UniSTS:161094

A007D11 (e-PCR)
- UniSTS:362

RH71435 (e-PCR)
- UniSTS:25838

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	ISO Inferred from Sequence Orthology more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antigen processing and presentation	ISO Inferred from Sequence Orthology more info
involved_in early endosome to Golgi transport	ISO Inferred from Sequence Orthology more info
involved_in intra-Golgi vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within intracellular protein transport	TAS Traceable Author Statement more info	PubMed
involved_in localization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peptidyl-cysteine methylation	ISO Inferred from Sequence Orthology more info	PubMed
involved_in protein localization to Golgi apparatus	ISO Inferred from Sequence Orthology more info
involved_in protein localization to Golgi membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info	PubMed
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
located_in acrosomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome to plasma membrane transport vesicle	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
is_active_in presynapse	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-6A

Names: RAB6, member RAS oncogene family; rab-6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163663.2 → NP_001157135.1 ras-related protein Rab-6A isoform 1

See identical proteins and their annotated locations for NP_001157135.1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (1) encodes isoform 1.

Source sequence(s)

AC124531

Consensus CDS

CCDS52323.1

UniProtKB/TrEMBL

D3YV69, Q3U4W5

Related

ENSMUSP00000095852.5, ENSMUST00000098252.5

Conserved Domains (1) summary

cd01861
Location:14 → 174

Rab6; Rab GTPase family 6 (Rab6)
NM_024287.5 → NP_077249.1 ras-related protein Rab-6A isoform 2

See identical proteins and their annotated locations for NP_077249.1

Status: VALIDATED

Description

Transcript Variant: Variants 1 and 2 include either one of two duplicated, alternatively spliced coding exons and are the same length. The resulting proteins (isoforms 1 and 2, respectively) are the same length but differ at three amino acid positions. This variant (2) encodes isoform 2.

Source sequence(s)

AC124531

Consensus CDS

CCDS21503.1

UniProtKB/Swiss-Prot

P35279, Q542M6, Q8R2Z7, Q8VEE5, Q9JJD4

UniProtKB/TrEMBL

D3YV69, Q0PD54

Related

ENSMUSP00000032946.4, ENSMUST00000032946.10

Conserved Domains (1) summary

cd01861
Location:14 → 174

Rab6; Rab GTPase family 6 (Rab6)