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Slu7 SLU7 splicing factor homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 193116, updated on 11-Apr-2024

Summary

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Official Symbol
Slu7provided by MGI
Official Full Name
SLU7 splicing factor homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2385598
See related
Ensembl:ENSMUSG00000020409 AllianceGenome:MGI:2385598
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Bwg0878e; D11Ertd730e
Summary
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.7), cerebellum adult (RPKM 5.2) and 27 other tissues See more
Orthologs
human all
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Genomic context

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See Slu7 in Genome Data Viewer
Location:
11 B1.1; 11 25.68 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (43324550..43338809)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (43433726..43447982)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 5782 Neighboring gene STARR-positive B cell enhancer ABC_E3940 Neighboring gene pituitary tumor-transforming gene 1 Neighboring gene STARR-positive B cell enhancer ABC_E6968 Neighboring gene predicted gene 12151 Neighboring gene C1q and tumor necrosis factor related protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice. Wang J, et al. Am J Pathol, 2018 Aug. PMID 29870742, Free PMC Article
  2. Splicing regulator SLU7 is essential for maintaining liver homeostasis. Elizalde M, et al. J Clin Invest, 2014 Jul. PMID 24865429, Free PMC Article
  3. An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing. Chua K, et al. Mol Cell Biol, 2001 Mar. PMID 11238888, Free PMC Article
  4. The RNA splicing factor hSlu7 is required for correct 3' splice-site choice. Chua K, et al. Nature, 1999 Nov 11. PMID 10647016
  5. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage. Gárate-Rascón M, et al. Hepatology, 2021 Nov. PMID 34170569

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4alpha Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
    Title: Splicing Factor SLU7 Prevents Oxidative Stress-Mediated Hepatocyte Nuclear Factor 4α Degradation, Preserving Hepatic Differentiation and Protecting From Liver Damage.
  2. Knockdown of hepatic Slu7 by adenovirus-Slu7shRNA treatment ameliorated inflammation and attenuated liver injury in mice after ethanol administration.
    Title: Hepatic Knockdown of Splicing Regulator Slu7 Ameliorates Inflammation and Attenuates Liver Injury in Ethanol-Fed Mice.
  3. SLU7 knockdown in liver resulted in profound changes in pre-mRNA splicing and gene expression, leading to impaired glucose and lipid metabolism, refractoriness to key metabolic hormones, and reversion to a fetal-like gene expression pattern.
    Title: Splicing regulator SLU7 is essential for maintaining liver homeostasis.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC31026

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pre-mRNA 3'-splice site binding ISO
Inferred from Sequence Orthology
more info
  
enables second spliceosomal transesterification activity ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in RNA splicing, via transesterification reactions ISO
Inferred from Sequence Orthology
more info
  
involved_in alternative mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to heat ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA 3'-splice site recognition ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of small nuclear ribonucleoprotein complex ISO
Inferred from Sequence Orthology
more info
  
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pre-mRNA-splicing factor SLU7
Names
step II splicing factor SLU7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_148673.3 → NP_683514.2  pre-mRNA-splicing factor SLU7

    See identical proteins and their annotated locations for NP_683514.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) is the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029117, AK047597, BY243619
    Consensus CDS
    CCDS24557.1
    UniProtKB/Swiss-Prot
    Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
    UniProtKB/TrEMBL
    Z4YM25
    Related
    ENSMUSP00000116609.2, ENSMUST00000151880.8
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  2. NM_198936.1 → NP_945174.1  pre-mRNA-splicing factor SLU7

    See identical proteins and their annotated locations for NP_945174.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional segment in its 5' UTR when compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK029117, AK047597, BY243619
    Consensus CDS
    CCDS24557.1
    UniProtKB/Swiss-Prot
    Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
    UniProtKB/TrEMBL
    Z4YM25
    Related
    ENSMUSP00000020681.4, ENSMUST00000020681.10
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    43324550..43338809
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011248823.3 → XP_011247125.1  pre-mRNA-splicing factor SLU7 isoform X1

    See identical proteins and their annotated locations for XP_011247125.1

    UniProtKB/Swiss-Prot
    Q3KQQ3, Q5SRU1, Q63ZX3, Q6P923, Q8BHJ9, Q8BL59, Q8BXD5, Q8R5C1, Q91YV6
    UniProtKB/TrEMBL
    Z4YM25
    Conserved Domains (1) summary
    pfam11708
    Location:161 → 434
    Slu7; Pre-mRNA splicing Prp18-interacting factor

  2. XM_036156451.1 → XP_036012344.1  pre-mRNA-splicing factor SLU7 isoform X2

    Conserved Domains (1) summary
    pfam11708
    Location:2 → 275
    Slu7; Pre-mRNA splicing Prp18-interacting factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BHJ9.1 GenPept UniProtKB/Swiss-Prot:Q8BHJ9

Gene LinkOut

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