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Nacad NAC alpha domain containing [ Mus musculus (house mouse) ]

Gene ID: 192950, updated on 11-Apr-2024

Summary

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Official Symbol
Nacadprovided by MGI
Official Full Name
NAC alpha domain containingprovided by MGI
Primary source
MGI:MGI:3603030
See related
Ensembl:ENSMUSG00000041073 AllianceGenome:MGI:3603030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0363; D230024G13Rik
Summary
Predicted to enable unfolded protein binding activity. Predicted to be involved in protein targeting to membrane. Predicted to act upstream of or within protein transport. Predicted to be located in nucleus. Predicted to be part of nascent polypeptide-associated complex. Predicted to be active in cytoplasm. Is expressed in gut; nervous system; and sensory organ. Orthologous to human NACAD (NAC alpha domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in whole brain E14.5 (RPKM 24.4), CNS E14 (RPKM 20.3) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 A1; 11 4.6 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (6547814..6556059, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (6597814..6606059, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24000 Neighboring gene cerebral cavernous malformation 2 Neighboring gene STARR-positive B cell enhancer mm9_chr11:6481502-6481803 Neighboring gene transforming growth factor beta regulated gene 4 Neighboring gene predicted gene, 24313 Neighboring gene small nucleolar RNA, H/ACA box 5C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2003 Aug 31. PMID 14621295
  2. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873
  3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • KIAA0363

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables unfolded protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nascent polypeptide-associated complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
NAC-alpha domain-containing protein 1
NP_001075121.1
XP_036012341.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081652.1 → NP_001075121.1  NAC-alpha domain-containing protein 1

    See identical proteins and their annotated locations for NP_001075121.1

    Status: VALIDATED

    Source sequence(s)
    BC072589
    Consensus CDS
    CCDS36108.1
    UniProtKB/Swiss-Prot
    Q5SWP3, Q6I6F5
    Related
    ENSMUSP00000049490.4, ENSMUST00000045713.4
    Conserved Domains (3) summary
    COG1308
    Location:1358 → 1504
    EGD2; Transcription factor homologous to NACalpha-BTF3 [Transcription]
    cd14416
    Location:1463 → 1504
    UBA_NACAD; UBA-like domain found in nascent polypeptide-associated complex subunit alpha domain-containing protein 1 (NACAD)
    pfam01849
    Location:1359 → 1412
    NAC; NAC domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    6547814..6556059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156448.1 → XP_036012341.1  NAC-alpha domain-containing protein 1 isoform X1

RNA

  1. XR_380961.2 RNA Sequence

  2. XR_003949359.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SWP3.1 GenPept UniProtKB/Swiss-Prot:Q5SWP3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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