Ptprt protein tyrosine phosphatase receptor type T [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprtprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Tprovided by MGI
Primary source: MGI:MGI:1321152
See related: Ensembl:ENSMUSG00000053141 AllianceGenome:MGI:1321152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: R-PTP-T; RPTPrho; RPTP-rfo; RPTP-rho; RPTPmam4; mRPTPrho; mKIAA0283
Summary: Enables several functions, including alpha-catenin binding activity; beta-catenin binding activity; and delta-catenin binding activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cell surface and plasma membrane. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; nervous system; respiratory system; sensory organ; and skeleton. Human ortholog(s) of this gene implicated in colorectal cancer and esophagus squamous cell carcinoma. Orthologous to human PTPRT (protein tyrosine phosphatase receptor type T). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 6.3), cortex adult (RPKM 4.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H2; 2 81.91 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (161363908..162503106, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (161521988..162661147, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ADAM10- and gamma-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease.
Title: ADAM10- and γ-secretase-dependent cleavage of the transmembrane protein PTPRT attenuates neurodegeneration in the mouse model of Alzheimer's disease.
Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.
Title: Hemopoietic Cell Kinase amplification with Protein Tyrosine Phosphatase Receptor T depletion leads to polycythemia, aberrant marrow erythoid maturation, and splenomegaly.
Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum.
Title: Inactivation of the catalytic phosphatase domain of PTPRT/RPTPρ increases social interaction in mice.
These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity
Title: PTPRT regulates high-fat diet-induced obesity and insulin resistance.
BCR is a novel substrate of PTPRT .
Title: Regulation of dendritic arborization by BCR Rac1 GTPase-activating protein, a substrate of PTPRT.
Data show that paxillin is a direct substrate of PTPRT and that PTPRT specifically regulates paxillin phosphorylation at tyrosine residue 88(Y88).
Title: Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Markers

NoName (e-PCR)
- UniSTS:237065

D2Mit170 (e-PCR), detects polymorphism
- UniSTS:129038

MHAa54b7.seq (e-PCR)
- UniSTS:125208

D2Mit412 (e-PCR), detects polymorphism
- UniSTS:129319

D2Mit197 (e-PCR), detects polymorphism
- UniSTS:129068

Ptpru (e-PCR), detects polymorphism
- UniSTS:507183

MT2016 (e-PCR)
- UniSTS:116280

AI450344 (e-PCR)
- UniSTS:160322

D2Mit452 (e-PCR), detects polymorphism
- UniSTS:129363

D2Mit452.2 (e-PCR), detects polymorphism
- UniSTS:129365

NoName (e-PCR)
- UniSTS:234591

G44775 (e-PCR)
- UniSTS:105577

G42933 (e-PCR)
- UniSTS:94828

D2Mit263.3 (e-PCR), detects polymorphism
- UniSTS:129145

D2Mit497 (e-PCR), detects polymorphism
- UniSTS:129416

D2Mit310 (e-PCR), detects polymorphism
- UniSTS:129202

RH131957 (e-PCR)
- UniSTS:215240

D2Mit142 (e-PCR), detects polymorphism
- UniSTS:129003

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables alpha-actinin binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	IDA Inferred from Direct Assay more info	PubMed
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables delta-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables delta-catenin binding	ISO Inferred from Sequence Orthology more info
enables gamma-catenin binding	IPI Inferred from Physical Interaction more info	PubMed
enables gamma-catenin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	TAS Traceable Author Statement more info
enables thiolester hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane receptor protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-6	ISO Inferred from Sequence Orthology more info
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in regulation of synapse organization	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	TAS Traceable Author Statement more info
is_active_in postsynaptic density membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase T

Names: receptor protein tyrosine phosphatase-rho; receptor-type tyrosine-protein phosphatase rho

NP_001278078.1

EC 3.1.3.48

NP_001278079.1

EC 3.1.3.48

NP_001278080.1

EC 3.1.3.48

NP_001407702.1

EC 3.1.3.48

NP_001407703.1

EC 3.1.3.48

NP_001407704.1

EC 3.1.3.48

NP_001407705.1

EC 3.1.3.48

NP_001407706.1

EC 3.1.3.48

NP_001407707.1

EC 3.1.3.48

NP_001407708.1

EC 3.1.3.48

NP_067439.1

EC 3.1.3.48

XP_011237686.1

EC 3.1.3.48

XP_011237687.1

EC 3.1.3.48

XP_017172075.1

EC 3.1.3.48

XP_017172076.1

EC 3.1.3.48

XP_017172079.1

EC 3.1.3.48

XP_017172081.1

EC 3.1.3.48

XP_017172082.1

EC 3.1.3.48

XP_017172083.1

EC 3.1.3.48

XP_017172084.1

EC 3.1.3.48

XP_017172087.1

EC 3.1.3.48

XP_017172089.1

EC 3.1.3.48

XP_030104650.1

EC 3.1.3.48

XP_036015594.1

EC 3.1.3.48

XP_036015600.1

EC 3.1.3.48

XP_036015601.1

EC 3.1.3.48

XP_036015602.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001291149.2 → NP_001278078.1 receptor-type tyrosine-protein phosphatase T isoform a precursor

See identical proteins and their annotated locations for NP_001278078.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform a.

Source sequence(s)

AL590415, AL591586, AL591598, AL591675, AL606841, AL645736

Consensus CDS

CCDS71182.1

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Related

ENSMUSP00000105067.2, ENSMUST00000109441.2

Conserved Domains (7) summary

cd06263
Location:36 → 193

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:882 → 1156

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:909 → 1156

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:506 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:298 → 364

fn3; Fibronectin type III domain

cl11960
Location:200 → 285

Ig; Immunoglobulin domain
NM_001291150.2 → NP_001278079.1 receptor-type tyrosine-protein phosphatase T isoform b precursor

See identical proteins and their annotated locations for NP_001278079.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains an additional in-frame exon but lacks a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (b) is shorter than isoform a.

Source sequence(s)

AL590415, AL591586, AL591598, AL591675, AL606841, AL645736

Consensus CDS

CCDS71183.1

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Related

ENSMUSP00000105069.2, ENSMUST00000109443.8

Conserved Domains (7) summary

cd06263
Location:36 → 193

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:892 → 1146

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:919 → 1146

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:506 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:298 → 364

fn3; Fibronectin type III domain

cl11960
Location:200 → 285

Ig; Immunoglobulin domain
NM_001291151.2 → NP_001278080.1 receptor-type tyrosine-protein phosphatase T isoform c precursor

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site and contains an additional in-frame exon but lacks a different in-frame exon in the central coding region, compared to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AL590415, AL591586, AL591598, AL591675, AL606841, AL645736

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (7) summary

cd06263
Location:36 → 193

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:891 → 1145

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:918 → 1145

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:506 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:298 → 364

fn3; Fibronectin type III domain

cl11960
Location:200 → 285

Ig; Immunoglobulin domain
NM_001420773.1 → NP_001407702.1 receptor-type tyrosine-protein phosphatase T isoform e precursor

Status: VALIDATED

Description

Transcript Variant: This variant (5) represents the longest transcript and encodes the longest isoform (e).

Source sequence(s)

AL590415, AL591586, AL591598, AL591675, AL606841, AL645736
NM_001420774.1 → NP_001407703.1 receptor-type tyrosine-protein phosphatase T isoform f precursor

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL591675, AL645736
NM_001420775.1 → NP_001407704.1 receptor-type tyrosine-protein phosphatase T isoform g precursor

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL645736
NM_001420776.1 → NP_001407705.1 receptor-type tyrosine-protein phosphatase T isoform h

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL591675, AL645736, AL645827
NM_001420777.1 → NP_001407706.1 receptor-type tyrosine-protein phosphatase T isoform h

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL591675, AL645736
NM_001420778.1 → NP_001407707.1 receptor-type tyrosine-protein phosphatase T isoform i

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL645736
NM_001420779.1 → NP_001407708.1 receptor-type tyrosine-protein phosphatase T isoform i

Status: VALIDATED

Source sequence(s)

AL590415, AL591598, AL645736
NM_021464.6 → NP_067439.1 receptor-type tyrosine-protein phosphatase T isoform d precursor

See identical proteins and their annotated locations for NP_067439.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks an alternate in-frame exon in the central coding region, compared to variant 1, resulting in an isoform (d) that is shorter than isoform a.

Source sequence(s)

AL590415, AL591586, AL591598, AL591675, AL606841, AL645736

Consensus CDS

CCDS17001.1

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Related

ENSMUSP00000105071.3, ENSMUST00000109445.9

Conserved Domains (7) summary

cd06263
Location:36 → 193

MAM; Meprin, A5 protein, and protein tyrosine phosphatase Mu (MAM) domain. MAM is an extracellular domain which mediates protein-protein interactions and is found in a diverse set of proteins, many of which are known to function in cell adhesion. Members ...

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

smart00194
Location:882 → 1136

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:909 → 1136

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:506 → 588

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:298 → 364

fn3; Fibronectin type III domain

cl11960
Location:200 → 285

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000068.8 Reference GRCm39 C57BL/6J

Range

161363908..162503106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036159701.1 → XP_036015594.1 receptor-type tyrosine-protein phosphatase T isoform X10

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (7) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:913 → 1169

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1254 → 1459

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain

pfam18861
Location:674 → 776

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl11960
Location:200 → 285

Ig; Immunoglobulin domain
XM_017316595.3 → XP_017172084.1 receptor-type tyrosine-protein phosphatase T isoform X8

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:914 → 1170

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1255 → 1460

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316593.3 → XP_017172082.1 receptor-type tyrosine-protein phosphatase T isoform X5

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:917 → 1173

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1258 → 1463

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316592.3 → XP_017172081.1 receptor-type tyrosine-protein phosphatase T isoform X4

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:923 → 1179

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1264 → 1469

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316590.3 → XP_017172079.1 receptor-type tyrosine-protein phosphatase T isoform X3

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:933 → 1189

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1274 → 1479

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316587.3 → XP_017172076.1 receptor-type tyrosine-protein phosphatase T isoform X2

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:935 → 1191

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1276 → 1481

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316586.3 → XP_017172075.1 receptor-type tyrosine-protein phosphatase T isoform X1

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:936 → 1192

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1277 → 1482

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_036159709.1 → XP_036015602.1 receptor-type tyrosine-protein phosphatase T isoform X15

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (6) summary

smart00137
Location:1 → 126

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:327 → 417

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:869 → 1125

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1210 → 1415

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:439 → 514

fn3; Fibronectin type III domain

cl11960
Location:133 → 218

Ig; Immunoglobulin domain
XM_036159708.1 → XP_036015601.1 receptor-type tyrosine-protein phosphatase T isoform X15

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (6) summary

smart00137
Location:1 → 126

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:327 → 417

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:869 → 1125

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1210 → 1415

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:439 → 514

fn3; Fibronectin type III domain

cl11960
Location:133 → 218

Ig; Immunoglobulin domain
XM_011239385.4 → XP_011237687.1 receptor-type tyrosine-protein phosphatase T isoform X15

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (6) summary

smart00137
Location:1 → 126

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:327 → 417

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:869 → 1125

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1210 → 1415

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:439 → 514

fn3; Fibronectin type III domain

cl11960
Location:133 → 218

Ig; Immunoglobulin domain
XM_036159707.1 → XP_036015600.1 receptor-type tyrosine-protein phosphatase T isoform X14

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (7) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:903 → 1139

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1224 → 1429

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain

pfam18861
Location:674 → 776

PTP_tm; Transmembrane domain of protein tyrosine phosphatase, receptor type J

cl11960
Location:200 → 285

Ig; Immunoglobulin domain
XM_017316600.3 → XP_017172089.1 receptor-type tyrosine-protein phosphatase T isoform X12

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:903 → 1159

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1244 → 1449

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_011239384.4 → XP_011237686.1 receptor-type tyrosine-protein phosphatase T isoform X13

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:917 → 1153

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1238 → 1443

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316598.3 → XP_017172087.1 receptor-type tyrosine-protein phosphatase T isoform X11

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

UniProtKB/TrEMBL

B1AQN2

Related

ENSMUSP00000105068.2, ENSMUST00000109442.8

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:923 → 1159

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1244 → 1449

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_030248790.2 → XP_030104650.1 receptor-type tyrosine-protein phosphatase T isoform X7

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:935 → 1171

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1256 → 1461

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain
XM_017316594.3 → XP_017172083.1 receptor-type tyrosine-protein phosphatase T isoform X6

UniProtKB/Swiss-Prot

Q99M80, Q99M81, Q99M82, Q9JIZ1, Q9JIZ2, Q9JKC2, Q9JLP0

Conserved Domains (5) summary

smart00137
Location:36 → 193

MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)

cd00063
Location:394 → 484

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14630
Location:936 → 1172

R-PTPc-T-1; catalytic domain of receptor-type tyrosine-protein phosphatase T, repeat 1

cd14634
Location:1257 → 1462

R-PTPc-T-2; PTP domain of receptor-type tyrosine-protein phosphatase T, repeat 2

pfam00041
Location:506 → 581

fn3; Fibronectin type III domain