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Ptprr protein tyrosine phosphatase receptor type R [ Mus musculus (house mouse) ]

Gene ID: 19279, updated on 11-Apr-2024

Summary

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Official Symbol
Ptprrprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Rprovided by MGI
Primary source
MGI:MGI:109559
See related
Ensembl:ENSMUSG00000020151 AllianceGenome:MGI:109559
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gmcp1; PTP-SL; PTPBR7; RPTPRR; mPTP213
Summary
Enables protein kinase binding activity and protein tyrosine phosphatase activity. Acts upstream of or within protein dephosphorylation. Predicted to be located in cell junction; cytosol; and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; and retina nuclear layer. Orthologous to human PTPRR (protein tyrosine phosphatase receptor type R). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 11.6), large intestine adult (RPKM 6.4) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D2; 10 64.01 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (115854093..116110837)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (116018188..116274932)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S3A pseudogene Neighboring gene STARR-seq mESC enhancer starr_27945 Neighboring gene STARR-seq mESC enhancer starr_27946 Neighboring gene STARR-seq mESC enhancer starr_27947 Neighboring gene RIKEN cDNA 4930422I22 gene Neighboring gene tetraspanin 8 Neighboring gene STARR-seq mESC enhancer starr_27948 Neighboring gene Taf7l2 Neighboring gene STARR-seq mESC enhancer starr_27949 Neighboring gene STARR-seq mESC enhancer starr_27950 Neighboring gene STARR-seq mESC enhancer starr_27951 Neighboring gene STARR-seq mESC enhancer starr_27952 Neighboring gene STARR-seq mESC enhancer starr_27953 Neighboring gene protein tyrosine phosphatase receptor type B Neighboring gene STARR-seq mESC enhancer starr_27954 Neighboring gene STARR-seq mESC enhancer starr_27955 Neighboring gene predicted gene, 26495 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4, opposite strand 1 Neighboring gene potassium large conductance calcium-activated channel, subfamily M, beta member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression. Erkens M, et al. Mol Brain, 2015 Jan 9. PMID 25571783, Free PMC Article
  2. Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory. Erkens M, et al. Behav Brain Res, 2014 May 15. PMID 24556203
  3. Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity. Noordman YE, et al. Biochim Biophys Acta, 2008 Feb. PMID 18068678
  4. Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice. Chirivi RG, et al. J Neurochem, 2007 May. PMID 17266727
  5. Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7. Dilaver G, et al. FEBS J, 2007 Jan. PMID 17147696

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These findings indicate an important role for PTPRR in maintaining low basal mitogen-activated protein kinase activity in Purkinje cells.
    Title: Protein tyrosine phosphatase receptor type R is required for Purkinje cell responsiveness in cerebellar long-term depression.
  2. The data of this study disclosed a distinct role for PTPRR in recognition memory and exploration of a new environment.
    Title: Protein tyrosine phosphatase receptor type R deficient mice exhibit increased exploration in a new environment and impaired novel object recognition memory.
  3. Results support the suggested link between PTPRR isoforms and cerebellar calcium ion homeostasis, and suggest an additional role in the process of cell-cell adhesion
    Title: PTPBR7 binding proteins in myelinating neurons of the mouse brain.
  4. PTP-SL, like PTPBR7, is a single membrane-spanning receptor-type protein tyrosine phosphatases.
    Title: Multimerisation of receptor-type protein tyrosine phosphatases PTPBR7 and PTP-SL attenuates enzymatic activity.
  5. Ptprr-/- mice displayed ataxia characterized by defects in fine motor coordination and balance skills.
    Title: Altered MAP kinase phosphorylation and impaired motor coordination in PTPRR deficient mice.
  6. PTPBR7, was subject to N-terminal proteolytic processing, in between amino acid position 136 and 137, resulting in an additional, 65-kDa transmembrane PTPRR isoform.
    Title: Proteolytic processing of the receptor-type protein tyrosine phosphatase PTPBR7.
  7. The ERK2 docking groove is more restrictive and selective for its tyrosine phosphatase inactivators than for MEK1/2 and indicate that distinct ERK2 residues modulate the docking interactions with activating and inactivating effectors.
    Title: ERK2 shows a restrictive and locally selective mechanism of recognition by its tyrosine phosphatase inactivators not shared by its activator MEK1.
  8. Multiple isoforms through the use of distinct promoters, alternative splicing and differential translation starts.
    Title: Characterization of multiple transcripts and isoforms derived from the mouse protein tyrosine phosphatase gene Ptprr.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ERBB2 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of epithelial cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase R
Names
R-PTP-R
STEP-like PTPase
phosphotyrosine phosphatase 13
protein-tyrosine-phosphatase-SL
NP_001155309.1
NP_001155310.1
NP_001155311.1
NP_001155312.1
NP_001345413.1
NP_035347.1
XP_006513445.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001161837.2 → NP_001155309.1  receptor-type tyrosine-protein phosphatase R isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC166836
    Consensus CDS
    CCDS56750.1
    UniProtKB/TrEMBL
    Q5U1V1
    Related
    ENSMUSP00000100907.3, ENSMUST00000105271.9
    Conserved Domains (2) summary
    smart00194
    Location:284 → 536
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:309 → 536
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  2. NM_001161838.2 → NP_001155310.1  receptor-type tyrosine-protein phosphatase R isoform c

    See identical proteins and their annotated locations for NP_001155310.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC166836
    Consensus CDS
    CCDS48693.1
    UniProtKB/TrEMBL
    Q5U1U8
    Related
    ENSMUSP00000114455.2, ENSMUST00000128399.2
    Conserved Domains (2) summary
    smart00194
    Location:147 → 399
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:172 → 399
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  3. NM_001161839.2 → NP_001155311.1  receptor-type tyrosine-protein phosphatase R isoform c

    See identical proteins and their annotated locations for NP_001155311.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC166836
    Consensus CDS
    CCDS48693.1
    UniProtKB/TrEMBL
    Q5U1U8
    Related
    ENSMUSP00000120965.2, ENSMUST00000148731.8
    Conserved Domains (2) summary
    smart00194
    Location:147 → 399
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:172 → 399
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  4. NM_001161840.2 → NP_001155312.1  receptor-type tyrosine-protein phosphatase R isoform c

    See identical proteins and their annotated locations for NP_001155312.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC166836
    Consensus CDS
    CCDS48693.1
    UniProtKB/TrEMBL
    Q5U1U8
    Related
    ENSMUSP00000122259.2, ENSMUST00000155606.8
    Conserved Domains (2) summary
    smart00194
    Location:147 → 399
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:172 → 399
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  5. NM_001358484.2 → NP_001345413.1  receptor-type tyrosine-protein phosphatase R isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (d) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AC166836
    UniProtKB/TrEMBL
    Q5U1U5, Q5U1V1
    Conserved Domains (1) summary
    cd00047
    Location:295 → 522
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

  6. NM_001428770.1 → NP_001415699.1  receptor-type tyrosine-protein phosphatase R isoform e precursor

    Status: VALIDATED

    Source sequence(s)
    AC124522, AC166836

  7. NM_011217.3 → NP_035347.1  receptor-type tyrosine-protein phosphatase R isoform a precursor

    See identical proteins and their annotated locations for NP_035347.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC124522, AC166836
    Consensus CDS
    CCDS24182.1
    UniProtKB/Swiss-Prot
    Q62132, Q64491, Q64492, Q9QUH9
    UniProtKB/TrEMBL
    Q5U1U6, Q8CEI8
    Related
    ENSMUSP00000064392.5, ENSMUST00000063470.11
    Conserved Domains (2) summary
    smart00194
    Location:391 → 643
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:416 → 643
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    115854093..116110837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006513382.2 → XP_006513445.1  receptor-type tyrosine-protein phosphatase R isoform X1

    Conserved Domains (1) summary
    cd14611
    Location:379 → 604
    R-PTPc-R; catalytic domain of receptor-type tyrosine-protein phosphatase R
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q62132.1 GenPept UniProtKB/Swiss-Prot:Q62132

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