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Kcnh6 potassium voltage-gated channel, subfamily H (eag-related), member 6 [ Mus musculus (house mouse) ]

Gene ID: 192775, updated on 5-Mar-2024

Summary

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Official Symbol
Kcnh6provided by MGI
Official Full Name
potassium voltage-gated channel, subfamily H (eag-related), member 6provided by MGI
Primary source
MGI:MGI:2684139
See related
Ensembl:ENSMUSG00000001901 AllianceGenome:MGI:2684139
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
m-erg2
Summary
Predicted to enable inward rectifier potassium channel activity. Predicted to be involved in ion transmembrane transport; regulation of heart rate by cardiac conduction; and regulation of ventricular cardiac muscle cell membrane repolarization. Predicted to be integral component of plasma membrane. Is expressed in several structures, including gut; male reproductive gland or organ; nervous system; retina; and skin. Used to study glucose metabolism disease. Orthologous to human KCNH6 (potassium voltage-gated channel subfamily H member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in colon adult (RPKM 1.9), frontal lobe adult (RPKM 1.4) and 17 other tissues See more
Orthologs
human all
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Genomic context

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See Kcnh6 in Genome Data Viewer
Location:
11 E1; 11 68.87 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (105898871..105926421)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106008044..106035595)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11651 Neighboring gene angiotensin I converting enzyme Neighboring gene predicted gene, 35971 Neighboring gene angiotensin I converting enzyme 3 Neighboring gene STARR-positive B cell enhancer ABC_E43 Neighboring gene DDB1 and CUL4 associated factor 7 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:105927234-105927440 Neighboring gene STARR-seq mESC enhancer starr_30915 Neighboring gene translational activator of mitochondrially encoded cytochrome c oxidase I

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KCNH6 protects pancreatic β-cells from endoplasmic reticulum stress and apoptosis. Lu J, et al. FASEB J, 2020 Nov. PMID 32918525
  2. Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism. Lu J, et al. Horm Metab Res, 2020 Sep. PMID 32750722
  3. Cisapride induced hypoglycemia via the KCNH6 potassium channel. Lu J, et al. Front Endocrinol (Lausanne), 2022. PMID 36325440, Free PMC Article
  4. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition. Zhang YC, et al. Oxid Med Cell Longev, 2022. PMID 36217412, Free PMC Article
  5. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel. Zhao MM, et al. Nat Commun, 2021 Sep 23. PMID 34556670, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes.
    Title: KCNH6 channel promotes insulin exocytosis via interaction with Munc18-1 independent of electrophysiological processes.
  2. KCNH6 is essential for insulin secretion by regulating intracellular ER Ca[2+] store.
    Title: KCNH6 is essential for insulin secretion by regulating intracellular ER Ca(2+) store.
  3. KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
    Title: KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca(2+) Regulation and Oxidative Stress Inhibition.
  4. Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
    Title: Berberine is an insulin secretagogue targeting the KCNH6 potassium channel.
  5. Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism.
    Title: Effect of KCNH6 on Hepatic Endoplasmic Reticulum Stress and Glucose Metabolism.
  6. KCNH6 protects pancreatic beta-cells from endoplasmic reticulum stress and apoptosis.
    Title: KCNH6 protects pancreatic β-cells from endoplasmic reticulum stress and apoptosis.
  7. dysfunction of KCNH6 causes overstimulation of insulin secretion in the short term and beta cell failure in the long term.
    Title: From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion.
  8. erg2 gene expression pattern in the developing embryo
    Title: Developmentally regulated expression of the mouse homologues of the potassium channel encoding genes m-erg1, m-erg2 and m-erg3.
  9. One of the abnormally elevated genes in Egr2Lo/Lo Schwann cells, Sox2, encodes a transcription factor that is crucial for maintenance of neural stem cell pluripotency.
    Title: Analysis of congenital hypomyelinating Egr2Lo/Lo nerves identifies Sox2 as an inhibitor of Schwann cell differentiation and myelination.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (4)  1 citation

General gene information

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Markers

Homology

Clone Names

  • MGC129366

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables inward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inward rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables voltage-gated potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in membrane repolarization during cardiac muscle cell action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of heart rate by cardiac conduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of ventricular cardiac muscle cell membrane repolarization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily H member 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001037712.2 → NP_001032801.1  potassium voltage-gated channel subfamily H member 6

    See identical proteins and their annotated locations for NP_001032801.1

    Status: VALIDATED

    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS25545.1
    UniProtKB/TrEMBL
    B1AR82, Q32ME0
    Related
    ENSMUSP00000001965.8, ENSMUST00000001965.14
    Conserved Domains (6) summary
    COG0664
    Location:588 → 701
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:594 → 705
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00130
    Location:41 → 132
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00520
    Location:296 → 520
    Ion_trans; Ion transport protein
    pfam07885
    Location:463 → 517
    Ion_trans_2; Ion channel
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    105898871..105926421
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532554.4 → XP_006532617.1  potassium voltage-gated channel subfamily H member 6 isoform X4

    UniProtKB/TrEMBL
    M0QW64
    Related
    ENSMUSP00000137675.2, ENSMUST00000145539.2
    Conserved Domains (2) summary
    PLN03192
    Location:259 → 698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  2. XM_006532550.4 → XP_006532613.1  potassium voltage-gated channel subfamily H member 6 isoform X1

    UniProtKB/TrEMBL
    B1AR82
    Conserved Domains (2) summary
    PLN03192
    Location:259 → 698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  3. XM_030245696.2 → XP_030101556.1  potassium voltage-gated channel subfamily H member 6 isoform X2

    UniProtKB/TrEMBL
    B1AR82
    Conserved Domains (2) summary
    PLN03192
    Location:259 → 698
    PLN03192; Voltage-dependent potassium channel; Provisional
    pfam13426
    Location:29 → 132
    PAS_9; PAS domain

  4. XM_006532551.5 → XP_006532614.1  potassium voltage-gated channel subfamily H member 6 isoform X3

    UniProtKB/TrEMBL
    B1AR82
    Conserved Domains (1) summary
    PLN03192
    Location:136 → 575
    PLN03192; Voltage-dependent potassium channel; Provisional

RNA

  1. XR_004936864.1 RNA Sequence

  2. XR_004936865.1 RNA Sequence

  3. XR_388374.4 RNA Sequence

  4. XR_004936866.1 RNA Sequence

  5. XR_003949358.2 RNA Sequence

  6. XR_003949357.2 RNA Sequence

  7. XR_004936867.1 RNA Sequence

  8. XR_388373.4 RNA Sequence

  9. XR_004936862.1 RNA Sequence

  10. XR_003949355.1 RNA Sequence

  11. XR_004936860.1 RNA Sequence

  12. XR_004936861.1 RNA Sequence

  13. XR_001779926.3 RNA Sequence

  14. XR_004936863.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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