Ptpro protein tyrosine phosphatase receptor type O [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptproprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Oprovided by MGI
Primary source: MGI:MGI:1097152
See related: Ensembl:ENSMUSG00000030223 AllianceGenome:MGI:1097152
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D28; PTPBK; PTPU2; PTPoc; GLEPP1; PTPROt; PTPphi; Ptpn15; R-PTP-O
Summary: Enables Wnt-protein binding activity; protein homodimerization activity; and protein tyrosine phosphatase activity. Involved in several processes, including peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; plasma membrane bounded cell projection organization; and slit diaphragm assembly. Located in several cellular components, including apical plasma membrane; glutamatergic synapse; and lateral plasma membrane. Is active in GABA-ergic synapse. Is integral component of postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and spinal cord. Human ortholog(s) of this gene implicated in nephrotic syndrome type 6. Orthologous to human PTPRO (protein tyrosine phosphatase receptor type O). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in frontal lobe adult (RPKM 15.3), CNS E18 (RPKM 13.3) and 9 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 G1; 6 66.75 cM

Exon count:: 32

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (137229189..137440251)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (137252299..137464634)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis.
Title: Developmental roles of glomerular epithelial protein-1 in mice molar morphogenesis.
Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
Title: Age-related decline in hippocampal tyrosine phosphatase PTPRO is a mechanistic factor in chemotherapy-related cognitive impairment.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Title: PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Data suggest that tyrosine (Tyr399) in PTPRQ Phosphatase (PTPROt) might participate in regulating the activity of this phosphatase toward src Kinases (Src).
Title: Phosphorylation of the phosphatase PTPROt at Tyr(399) is a molecular switch that controls osteoclast activity and bone mass in vivo.
Using loss-of-function and gain-of-function approaches, we show that PTPRO promotes the formation of excitatory synapses
Title: Identification of Protein Tyrosine Phosphatase Receptor Type O (PTPRO) as a Synaptic Adhesion Molecule that Promotes Synapse Formation.
PTPROt thus functions as an obligate haploinsufficient TS in CLL, where its expression levels determine its role as a promoter or inhibitor of the tumorigenic process in mice. Partial loss of PTPROt generates the strongest disease phenotype, suggesting that its intermediate expression levels in CLL are selected for.
Title: The PTPROt tyrosine phosphatase functions as an obligate haploinsufficient tumor suppressor in vivo in B-cell chronic lymphocytic leukemia.
TLR4 and NF-kappaB/p65 phosphorylation was significantly enhanced in PTPRO over-expressing cells, while significantly down-regulated in PTPRO knockout cells. PTPRO plays ital roles in atherosclerosis (AS) via promoting ox-LDL induced oxidative stress and cell apoptosis through TLR4/NF-kappaB pathway.
Title: PTPRO Promotes Oxidized Low-Density Lipoprotein Induced Oxidative Stress and Cell Apoptosis through Toll-Like Receptor 4/Nuclear Factor κB Pathway.
PTPRO plays an important role in FH by interacting with TLR4.
Title: Aggravated Liver Injury but Attenuated Inflammation in PTPRO-Deficient Mice Following LPS/D-GaIN Induced Fulminant Hepatitis.
Study show that EphA4 is a substrate for PTP-oc in osteoclasts and that the molecular mechanism contributing to the PTP-oc-induced up-regulation of the osteoclast activity in part involves its dephosphorylation and inactivation of the EphA4 signaling.
Title: An Osteoclastic Transmembrane Protein-Tyrosine Phosphatase Enhances Osteoclast Activity in Part by Dephosphorylating EphA4 in Osteoclasts.
PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment.
Title: PTPROt maintains T cell immunity in the microenvironment of hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Mit291 (e-PCR), detects polymorphism
- UniSTS:130839

Ptpro (e-PCR), detects polymorphism
- UniSTS:495996

Ptpro (e-PCR), detects polymorphism
- UniSTS:256892

39.MMHAP34FRE12.seq (e-PCR)
- UniSTS:124320

Ptpro (e-PCR), detects polymorphism
- UniSTS:186529

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	IDA Inferred from Direct Assay more info	PubMed
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in glomerulus development	ISO Inferred from Sequence Orthology more info
involved_in lamellipodium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of glomerular filtration	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-tyrosine dephosphorylation	ISO Inferred from Sequence Orthology more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in podocyte differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in podocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of glomerular filtration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of glomerular filtration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in slit diaphragm assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in GABA-ergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in GABA-ergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in GABA-ergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IBA Inferred from Biological aspect of Ancestor more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IEP Inferred from Expression Pattern more info	PubMed

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase O

Names: PTPase U2; glomerular epithelial protein 1; protein tyrosine phosphatase U2; protein tyrosine phosphatase, non-receptor type 15; receptor protein tyrosine phosphatase RO

NP_001157873.1

EC 3.1.3.48

NP_001157874.1

EC 3.1.3.48

NP_001157875.1

EC 3.1.3.48

NP_001397204.1

EC 3.1.3.48

NP_035346.3

EC 3.1.3.48

XP_036021846.1

EC 3.1.3.48

XP_036021847.1

EC 3.1.3.48

XP_036021848.1

EC 3.1.3.48

XP_036021849.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164401.2 → NP_001157873.1 receptor-type tyrosine-protein phosphatase O isoform 2 precursor

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC093120, AC144767, AC163627

Consensus CDS

CCDS51943.1

UniProtKB/TrEMBL

E9Q4I1, Q9JLU0

Related

ENSMUSP00000127112.2, ENSMUST00000167679.8

Conserved Domains (4) summary

smart00194
Location:919 → 1174

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:947 → 1175

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:444 → 536

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:735 → 815

fn3; Fibronectin type III domain
NM_001164402.2 → NP_001157874.1 receptor-type tyrosine-protein phosphatase O isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC093120, AC163627

Consensus CDS

CCDS51944.1

UniProtKB/TrEMBL

E9PVJ6, Q60998, Q60999, Q61000

Related

ENSMUSP00000131764.2, ENSMUST00000167002.4

Conserved Domains (2) summary

smart00194
Location:126 → 381

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:154 → 382

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001164403.2 → NP_001157875.1 receptor-type tyrosine-protein phosphatase O isoform 4

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences causes translation initiation at a downstream AUG, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.

Source sequence(s)

AC093120, AC163627

Consensus CDS

CCDS85176.1

UniProtKB/TrEMBL

A0A0N4SUY2, Q4U214

Related

ENSMUSP00000144870.2, ENSMUST00000203914.2

Conserved Domains (2) summary

smart00194
Location:98 → 353

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:126 → 354

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
NM_001410275.1 → NP_001397204.1 receptor-type tyrosine-protein phosphatase O isoform 5

Status: VALIDATED

Source sequence(s)

AC093120, AC163627

UniProtKB/TrEMBL

Q3UWY6
NM_011216.4 → NP_035346.3 receptor-type tyrosine-protein phosphatase O isoform 1 precursor

See identical proteins and their annotated locations for NP_035346.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC093120, AC144767, AC163627

Consensus CDS

CCDS20664.1

UniProtKB/Swiss-Prot

E9Q612, Q7TSY7

UniProtKB/TrEMBL

Q9ERM5

Related

ENSMUSP00000076364.7, ENSMUST00000077115.13

Conserved Domains (4) summary

smart00194
Location:947 → 1202

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:975 → 1203

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:444 → 536

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:735 → 815

fn3; Fibronectin type III domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000072.7 Reference GRCm39 C57BL/6J

Range

137229189..137440251

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036165953.1 → XP_036021846.1 receptor-type tyrosine-protein phosphatase O isoform X1

UniProtKB/TrEMBL

Q9ERM5

Conserved Domains (3) summary

cd00063
Location:479 → 571

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14614
Location:996 → 1240

R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O

pfam00041
Location:770 → 850

fn3; Fibronectin type III domain
XM_036165954.1 → XP_036021847.1 receptor-type tyrosine-protein phosphatase O isoform X2

UniProtKB/TrEMBL

Q9JLU0

Conserved Domains (3) summary

cd00063
Location:479 → 571

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14614
Location:968 → 1212

R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O

pfam00041
Location:770 → 850

fn3; Fibronectin type III domain
XM_036165956.1 → XP_036021849.1 receptor-type tyrosine-protein phosphatase O isoform X4

UniProtKB/TrEMBL

Q9ERM5

Conserved Domains (3) summary

cd00063
Location:279 → 371

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14614
Location:796 → 1040

R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O

pfam00041
Location:570 → 650

fn3; Fibronectin type III domain
XM_036165955.1 → XP_036021848.1 receptor-type tyrosine-protein phosphatase O isoform X3

UniProtKB/TrEMBL

Q9ERM5

Conserved Domains (3) summary

cd00063
Location:443 → 535

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14614
Location:960 → 1204

R-PTPc-O; catalytic domain of receptor-type tyrosine-protein phosphatase O

pfam00041
Location:734 → 814

fn3; Fibronectin type III domain