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Ptprm protein tyrosine phosphatase receptor type M [ Mus musculus (house mouse) ]

Gene ID: 19274, updated on 11-Apr-2024

Summary

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Official Symbol
Ptprmprovided by MGI
Official Full Name
protein tyrosine phosphatase receptor type Mprovided by MGI
Primary source
MGI:MGI:102694
See related
Ensembl:ENSMUSG00000033278 AllianceGenome:MGI:102694
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RPTPmu; mKIAA4044
Summary
Predicted to enable cadherin binding activity; identical protein binding activity; and transmembrane receptor protein tyrosine phosphatase activity. Acts upstream of or within vasodilation. Predicted to be located in several cellular components, including adherens junction; lamellipodium; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and sensory organ. Orthologous to human PTPRM (protein tyrosine phosphatase receptor type M). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 20.9), heart adult (RPKM 9.9) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
17 E1.1; 17 37.88 cM
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (66973843..67661486, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (66666848..67354491, complement)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43079 Neighboring gene STARR-seq mESC enhancer starr_43080 Neighboring gene thymocyte selection associated family member 3 Neighboring gene VISTA enhancer mm1745 Neighboring gene predicted gene, 46576 Neighboring gene RIKEN cDNA 1700016K05 gene Neighboring gene STARR-seq mESC enhancer starr_43082 Neighboring gene STARR-seq mESC enhancer starr_43083 Neighboring gene actin related protein 2/3 complex, subunit 1A pseudogene Neighboring gene STARR-seq mESC enhancer starr_43084 Neighboring gene STARR-seq mESC enhancer starr_43085 Neighboring gene predicted gene, 49940 Neighboring gene STARR-seq mESC enhancer starr_43086 Neighboring gene STARR-seq mESC enhancer starr_43088 Neighboring gene microRNA 5709 Neighboring gene STARR-seq mESC enhancer starr_43089 Neighboring gene STARR-seq mESC enhancer starr_43090 Neighboring gene STARR-seq mESC enhancer starr_43091 Neighboring gene STARR-seq mESC enhancer starr_43092 Neighboring gene predicted gene, 52313 Neighboring gene predicted gene, 36152 Neighboring gene STARR-seq mESC enhancer starr_43094 Neighboring gene STARR-seq mESC enhancer starr_43095 Neighboring gene STARR-seq mESC enhancer starr_43096 Neighboring gene predicted gene, 36201

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes. de Rooij KE, et al. Histochem Cell Biol, 2015 Jul. PMID 25850409, Free PMC Article
  2. Receptor protein tyrosine phosphatase mu expression as a marker for endothelial cell heterogeneity; analysis of RPTPmu gene expression using LacZ knock-in mice. Koop EA, et al. Int J Dev Biol, 2003 Jun. PMID 12895029
  3. RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation. Kim WK, et al. Mol Biol Cell, 2011 Dec. PMID 21998202, Free PMC Article
  4. Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice. Koop EA, et al. Am J Physiol Heart Circ Physiol, 2005 Mar. PMID 15706045
  5. Differential expression of MAM-subfamily protein tyrosine phosphatases during mouse development. Fuchs M, et al. Mech Dev, 1998 Jan. PMID 9510027

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. histochemical analysis showed that within bone, RPTPmu is expressed exclusively in early-stage osteocytes and therefore is a new marker for osteocytes
    Title: Identification of receptor-type protein tyrosine phosphatase μ as a new marker for osteocytes.
  2. differentiation into adipocytes is controlled by RPTPmu
    Title: RPTPμ tyrosine phosphatase promotes adipogenic differentiation via modulation of p120 catenin phosphorylation.
  3. RPTPmu is involved in the mechanotransduction or accessory signaling pathways that control shear stress responses in mesenteric resistance arteries.
    Title: Impaired flow-induced dilation in mesenteric resistance arteries from receptor protein tyrosine phosphatase-mu-deficient mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA4044, MGC90724

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables transmembrane receptor protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in response to xenobiotic stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in retina layer formation ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal ganglion cell axon guidance ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within vasodilation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase mu
Names
R-PTP-mu
protein-tyrosine phosphatase mu
NP_001344554.1
NP_033010.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357625.1 → NP_001344554.1  receptor-type tyrosine-protein phosphatase mu isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AK164246, BC079621, BP758008, BP758009
    Consensus CDS
    CCDS89138.1
    UniProtKB/TrEMBL
    Q68FM4
    Related
    ENSMUSP00000045603.10, ENSMUST00000037974.10
    Conserved Domains (6) summary
    smart00060
    Location:383 → 467
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    smart00194
    Location:933 → 1187
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:1249 → 1481
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain
    pfam00041
    Location:499 → 574
    fn3; Fibronectin type III domain

  2. NM_008984.2 → NP_033010.2  receptor-type tyrosine-protein phosphatase mu precursor

    See identical proteins and their annotated locations for NP_033010.2

    Status: VALIDATED

    Source sequence(s)
    AU254682, BC079621, BP758008, X58287
    Consensus CDS
    CCDS28948.1
    UniProtKB/Swiss-Prot
    E9QKU4, P28828, Q571L8
    Related
    ENSMUSP00000153662.2, ENSMUST00000223982.2
    Conserved Domains (6) summary
    smart00060
    Location:383 → 467
    FN3; Fibronectin type 3 domain
    smart00137
    Location:22 → 182
    MAM; Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
    cd14633
    Location:884 → 1156
    R-PTPc-M-1; catalytic domain of receptor-type tyrosine-protein phosphatase M, repeat 1
    cd14635
    Location:1242 → 1447
    R-PTPc-M-2; PTP domain of receptor-type tyrosine-protein phosphatase M, repeat 2
    pfam00041
    Location:499 → 574
    fn3; Fibronectin type III domain
    pfam00047
    Location:192 → 274
    ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    66973843..67661486 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P28828.2 GenPept UniProtKB/Swiss-Prot:P28828

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