Ttc36 tetratricopeptide repeat domain 36 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ttc36provided by MGI
Official Full Name: tetratricopeptide repeat domain 36provided by MGI
Primary source: MGI:MGI:2384760
See related: Ensembl:ENSMUSG00000039438 AllianceGenome:MGI:2384760
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Acts upstream of or within several processes, including learning or memory; negative regulation of cellular protein metabolic process; and tyrosine metabolic process. Is expressed in cerebral cortex ventricular layer; forelimb bud; genitourinary system; and liver. Orthologous to human TTC36 (tetratricopeptide repeat domain 36). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver adult (RPKM 842.4), kidney adult (RPKM 543.0) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44710697..44714248, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44799400..44802951, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Collectively, on the basis of the expression pattern, Ttc36 is specifically expressed in proximal distal tubules
Title: The expression patterns of Tetratricopeptide repeat domain 36 (Ttc36).

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within central nervous system neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within memory	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-threonine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein binding	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of protein binding	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein polyubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within tyrosine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within visual learning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: tetratricopeptide repeat protein 36

Names: TPR repeat protein 36

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_138951.1 → NP_620401.1 tetratricopeptide repeat protein 36

See identical proteins and their annotated locations for NP_620401.1

Status: PROVISIONAL

Source sequence(s)

BC024432

Consensus CDS

CCDS23121.1

UniProtKB/Swiss-Prot

Q8VBW8

Related

ENSMUSP00000042183.7, ENSMUST00000044694.8

Conserved Domains (3) summary

sd00006
Location:48 → 76

TPR; TPR repeat [structural motif]

pfam00515
Location:82 → 111

TPR_1; Tetratricopeptide repeat

pfam13414
Location:48 → 112

TPR_11; TPR repeat