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Wdr81 WD repeat domain 81 [ Mus musculus (house mouse) ]

Gene ID: 192652, updated on 21-Apr-2024

Summary

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Official Symbol
Wdr81provided by MGI
Official Full Name
WD repeat domain 81provided by MGI
Primary source
MGI:MGI:2681828
See related
Ensembl:ENSMUSG00000045374 AllianceGenome:MGI:2681828
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
nur5; Gm883; mFLJ00182
Summary
Predicted to enable K63-linked polyubiquitin modification-dependent protein binding activity and phosphatidylinositol 3-kinase regulator activity. Involved in mitochondrion organization. Located in mitochondrion. Human ortholog(s) of this gene implicated in cerebellar ataxia, mental retardation and dysequlibrium syndrome and hydrocephalus. Orthologous to human WDR81 (WD repeat domain 81). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 9.0), thymus adult (RPKM 8.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B5; 11 45.89 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75331769..75345544, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75440943..75454808, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12337 Neighboring gene serine (or cysteine) peptidase inhibitor, clade F, member 2 Neighboring gene predicted gene, 35391 Neighboring gene STARR-positive B cell enhancer ABC_E3973 Neighboring gene STARR-positive B cell enhancer ABC_E10687 Neighboring gene STARR-seq mESC enhancer starr_29995 Neighboring gene Mir22 host gene (non-protein coding) Neighboring gene microRNA 22 Neighboring gene TLC domain containing 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. WDR81 regulates adult hippocampal neurogenesis through endosomal SARA-TGFβ signaling. Wang M, et al. Mol Psychiatry, 2021 Feb. PMID 30531936, Free PMC Article
  2. WDR81 is necessary for purkinje and photoreceptor cell survival. Traka M, et al. J Neurosci, 2013 Apr 17. PMID 23595742, Free PMC Article
  3. Endosomal trafficking defects alter neural progenitor proliferation and cause microcephaly. Carpentieri JA, et al. Nat Commun, 2022 Jan 10. PMID 35013230, Free PMC Article
  4. The BEACH-containing protein WDR81 coordinates p62 and LC3C to promote aggrephagy. Liu X, et al. J Cell Biol, 2017 May 1. PMID 28404643, Free PMC Article
  5. Functional genetic analysis of mouse chromosome 11. Kile BT, et al. Nature, 2003 Sep 4. PMID 12955145

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC32441

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K63-linked polyubiquitin modification-dependent protein binding ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol 3-kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables phosphatidylinositol 3-kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in aggrephagy IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aggrephagy ISO
Inferred from Sequence Orthology
more info
  
involved_in early endosome to late endosome transport ISO
Inferred from Sequence Orthology
more info
  
involved_in mitochondrion organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in autophagosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosomal membrane ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WD repeat-containing protein 81
Names
shakey 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138950.2 → NP_620400.2  WD repeat-containing protein 81

    See identical proteins and their annotated locations for NP_620400.2

    Status: VALIDATED

    Source sequence(s)
    AK160585, AL591496, BC061040, CN721357
    Consensus CDS
    CCDS48849.1
    UniProtKB/Swiss-Prot
    G5E8V0, Q3TA90, Q3TUS9, Q5ND34, Q6KAR1
    UniProtKB/TrEMBL
    K4DI77
    Related
    ENSMUSP00000134266.2, ENSMUST00000173320.8
    Conserved Domains (4) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    COG2319
    Location:1624 → 1932
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:1645 → 1688
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:1634 → 1932
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    75331769..75345544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006532548.5 → XP_006532611.1  WD repeat-containing protein 81 isoform X3

    UniProtKB/TrEMBL
    K4DI77
    Conserved Domains (3) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    sd00039
    Location:1645 → 1688
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1634 → 1872
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006532547.5 → XP_006532610.1  WD repeat-containing protein 81 isoform X2

    UniProtKB/TrEMBL
    K4DI77
    Conserved Domains (3) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    sd00039
    Location:1656 → 1699
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1645 → 1883
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  3. XM_006532546.5 → XP_006532609.1  WD repeat-containing protein 81 isoform X1

    UniProtKB/TrEMBL
    K4DI77
    Conserved Domains (3) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...
    sd00039
    Location:1656 → 1699
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:1645 → 1943
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_036156441.1 → XP_036012334.1  WD repeat-containing protein 81 isoform X4

    Conserved Domains (1) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

  5. XM_011248816.4 → XP_011247118.1  WD repeat-containing protein 81 isoform X5

    Conserved Domains (1) summary
    cd06071
    Location:349 → 589
    Beach; BEACH (Beige and Chediak-Higashi) domains, implicated in membrane trafficking, are present in a family of proteins conserved throughout eukaryotes. This group contains human lysosomal trafficking regulator (LYST), LPS-responsive and beige-like anchor ...

RNA

  1. XR_388371.5 RNA Sequence

  2. XR_879536.4 RNA Sequence

  3. XR_388372.5 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5ND34.2 GenPept UniProtKB/Swiss-Prot:Q5ND34

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