Ptprc protein tyrosine phosphatase receptor type C [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptprcprovided by MGI
Official Full Name: protein tyrosine phosphatase receptor type Cprovided by MGI
Primary source: MGI:MGI:97810
See related: Ensembl:ENSMUSG00000026395 AllianceGenome:MGI:97810
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: loc; B220; Cd45; L-CA; Ly-5; T200; CD45R; Lyt-4
Summary: Enables several functions, including heparan sulfate proteoglycan binding activity; heparin binding activity; and protein tyrosine phosphatase activity. Involved in several processes, including lymphocyte differentiation; positive regulation of macromolecule metabolic process; and regulation of signal transduction. Acts upstream of or within several processes, including lymphocyte differentiation; positive regulation of lymphocyte activation; and regulation of protein phosphorylation. Located in external side of plasma membrane; focal adhesion; and membrane raft. Is expressed in several structures, including 3rd branchial arch; alimentary system; cardiovascular system; hemolymphoid system; and placenta. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in hepatitis C; multiple sclerosis; severe combined immunodeficiency; and severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-positive, Nk cell-positive. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in spleen adult (RPKM 50.1), thymus adult (RPKM 49.7) and 5 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 E4; 1 60.73 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (137990601..138103491, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (138062859..138175756, complement)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CD45 limits early Natural Killer cell development.
Title: CD45 limits early Natural Killer cell development.
Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells.
Title: Murine Bone Marrow Erythroid Cells Have Two Branches of Differentiation Defined by the Presence of CD45 and a Different Immune Transcriptome Than Fetal Liver Erythroid Cells.
CD45.1/CD45.2 Congenic Markers Induce a Selective Bias for CD8+ T Cells during Adoptive Lymphocyte Reconstitution in Lymphocytopenia Mice.
Title: CD45.1/CD45.2 Congenic Markers Induce a Selective Bias for CD8+ T Cells during Adoptive Lymphocyte Reconstitution in Lymphocytopenia Mice.
CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s.
Title: CD45 alleviates airway inflammation and lung fibrosis by limiting expansion and activation of ILC2s.
Murine Placental Erythroid Cells Are Mainly Represented by CD45[+] Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
Title: Murine Placental Erythroid Cells Are Mainly Represented by CD45(+) Immunosuppressive Erythroid Cells and Secrete CXCL1, CCL2, CCL3 and CCL4 Chemokines.
The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
Title: The inhibitory coreceptor CD22 restores B cell signaling by developmentally regulating Cd45(-/-) immunodeficient B cells.
Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
Title: Integration of T helper and BCR signals governs enhanced plasma cell differentiation of memory B cells by regulation of CD45 phosphatase activity.
The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1beta-mediated autoinflammatory osteomyelitis.
Title: The receptor-type protein tyrosine phosphatase CD45 promotes onset and severity of IL-1β-mediated autoinflammatory osteomyelitis.
Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells.
Title: Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells.
CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition.
Title: CD45 pre-exclusion from the tips of T cell microvilli prior to antigen recognition.

Submit: New GeneRIF Correction See all GeneRIFs (112)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (7) 1 citation
Chemically induced (ENU) (18) 1 citation
Not Applicable (3) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ptprc (e-PCR), detects polymorphism
- UniSTS:463366

NoName (e-PCR)
- UniSTS:548186

D1Mit514 (e-PCR), detects polymorphism
- UniSTS:142251

AU026553 (e-PCR)
- UniSTS:114168

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ankyrin binding	ISO Inferred from Sequence Orthology more info
enables heparan sulfate proteoglycan binding	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in B cell receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in T cell receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in T cell receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in bone marrow development	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling using intracellular calcium source	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell cycle phase transition	ISO Inferred from Sequence Orthology more info
involved_in cellular response to extracellular stimulus	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within defense response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heterotypic cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell adhesion involved in substrate-bound cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cytokine-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of protein kinase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein tyrosine kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of peptidyl-tyrosine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in plasma membrane raft distribution	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Fc receptor mediated stimulatory signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAP kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of MAPK cascade	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of T cell mediated immunity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of alpha-beta T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of antigen receptor-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of gamma-delta T cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of hematopoietic stem cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of immunoglobulin production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-2 production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of isotype switching to IgG isotypes	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of peptidyl-tyrosine phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phagocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein tyrosine phosphatase activity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of stem cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive thymic T cell selection	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of protein autophosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein dephosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of extrinsic apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of humoral immune response mediated by circulating immunoglobulin	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in regulation of phagocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of protein tyrosine kinase activity	ISO Inferred from Sequence Orthology more info
involved_in regulation of receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to gamma radiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in bleb	ISO Inferred from Sequence Orthology more info
located_in cell periphery	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane microdomain	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	IGI Inferred from Genetic Interaction more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: receptor-type tyrosine-protein phosphatase C

Names: leukocyte common antigen; lymphocyte antigen 5; lymphocyte common antigen

NP_001104786.2

EC 3.1.3.48

NP_001255215.1

EC 3.1.3.48

NP_001407709.1

EC 3.1.3.48

NP_001407710.1

EC 3.1.3.48

NP_035340.3

EC 3.1.3.48

XP_006529321.1

EC 3.1.3.48

XP_006529322.1

EC 3.1.3.48

XP_006529323.1

EC 3.1.3.48

XP_006529324.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001111316.3 → NP_001104786.2 receptor-type tyrosine-protein phosphatase C isoform 1 precursor

See identical proteins and their annotated locations for NP_001104786.2

Status: VALIDATED

Source sequence(s)

AC122903, AC159278

Consensus CDS

CCDS48383.2

UniProtKB/Swiss-Prot

E9QLT5, P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1, S4R1S4, S4R2V1

UniProtKB/TrEMBL

Q64730

Conserved Domains (6) summary

cd00063
Location:474 → 553

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:27 → 191

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14557
Location:696 → 896

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:1006 → 1211

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:212 → 265

CD45; Leukocyte receptor CD45
NM_001268286.2 → NP_001255215.1 receptor-type tyrosine-protein phosphatase C isoform 3 precursor

Status: VALIDATED

Source sequence(s)

AC122903, AC159278

Consensus CDS

CCDS59542.1

UniProtKB/TrEMBL

Q3U382, S4R1M0

Related

ENSMUSP00000138275.2, ENSMUST00000182755.8

Conserved Domains (5) summary

smart00194
Location:478 → 737

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:506 → 737

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:311 → 390

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:49 → 102

CD45; Leukocyte receptor CD45
NM_001420780.1 → NP_001407709.1 receptor-type tyrosine-protein phosphatase C isoform 5 precursor

Status: VALIDATED

Source sequence(s)

AC122903, AC159278
NM_001420781.1 → NP_001407710.1 receptor-type tyrosine-protein phosphatase C isoform 4 precursor

Status: VALIDATED

Source sequence(s)

AC122903, AC159278
NM_011210.5 → NP_035340.3 receptor-type tyrosine-protein phosphatase C isoform 2 precursor

See identical proteins and their annotated locations for NP_035340.3

Status: VALIDATED

Source sequence(s)

AC122903, AC159278

Consensus CDS

CCDS15330.2

UniProtKB/TrEMBL

Q3U382

Related

ENSMUSP00000138800.2, ENSMUST00000182283.8

Conserved Domains (5) summary

smart00194
Location:502 → 761

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:530 → 761

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

cd00063
Location:335 → 414

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:73 → 126

CD45; Leukocyte receptor CD45

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000067.7 Reference GRCm39 C57BL/6J

Range

137990601..138103491 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006529258.4 → XP_006529321.1 receptor-type tyrosine-protein phosphatase C isoform X1

See identical proteins and their annotated locations for XP_006529321.1

UniProtKB/Swiss-Prot

E9QLT5, P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1, S4R1S4, S4R2V1

UniProtKB/TrEMBL

Q64730

Conserved Domains (6) summary

cd00063
Location:474 → 553

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:27 → 191

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14557
Location:696 → 896

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:1006 → 1211

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:212 → 265

CD45; Leukocyte receptor CD45
XM_006529259.4 → XP_006529322.1 receptor-type tyrosine-protein phosphatase C isoform X1

See identical proteins and their annotated locations for XP_006529322.1

UniProtKB/Swiss-Prot

E9QLT5, P06800, Q61812, Q61813, Q61814, Q61815, Q78EF1, S4R1S4, S4R2V1

UniProtKB/TrEMBL

Q64730

Conserved Domains (6) summary

cd00063
Location:474 → 553

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:27 → 191

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14557
Location:696 → 896

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:1006 → 1211

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:212 → 265

CD45; Leukocyte receptor CD45
XM_006529260.1 → XP_006529323.1 receptor-type tyrosine-protein phosphatase C isoform X2

UniProtKB/TrEMBL

Q64730

Conserved Domains (6) summary

PHA03255
Location:18 → 150

PHA03255; BDLF3; Provisional

cd00063
Location:431 → 510

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd14557
Location:653 → 853

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:963 → 1168

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:169 → 222

CD45; Leukocyte receptor CD45
XM_006529261.5 → XP_006529324.1 receptor-type tyrosine-protein phosphatase C isoform X3

UniProtKB/TrEMBL

Q64730

Conserved Domains (6) summary

cd00063
Location:427 → 506

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam05109
Location:13 → 143

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)

cd14557
Location:649 → 849

R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1

cd14558
Location:959 → 1164

R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

pfam12453
Location:7 → 31

PTP_N; Protein tyrosine phosphatase N terminal

pfam12567
Location:165 → 218

CD45; Leukocyte receptor CD45