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Sirpa signal-regulatory protein alpha [ Mus musculus (house mouse) ]

Gene ID: 19261, updated on 3-Apr-2024

Summary

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Official Symbol
Sirpaprovided by MGI
Official Full Name
signal-regulatory protein alphaprovided by MGI
Primary source
MGI:MGI:108563
See related
Ensembl:ENSMUSG00000037902 AllianceGenome:MGI:108563
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; Idd13.2
Summary
Enables protein phosphatase binding activity and protein phosphorylated amino acid binding activity. Involved in several processes, including negative regulation of MAPK cascade; negative regulation of cytokine production; and negative regulation of nitrogen compound metabolic process. Acts upstream of or within several processes, including hematopoietic progenitor cell differentiation; phagocytosis; and positive regulation of phagocytosis. Is integral component of plasma membrane. Is expressed in several structures, including adrenal gland; cartilage; central nervous system; genitourinary system; and retina. Orthologous to several human genes including SIRPA (signal regulatory protein alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in cortex adult (RPKM 59.8), frontal lobe adult (RPKM 57.5) and 25 other tissues See more
Orthologs
human all
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Genomic context

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Location:
2 F1; 2 63.19 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (129432962..129474148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (129591042..129632228)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA F830045P16 gene Neighboring gene predicted gene 14040 Neighboring gene STARR-seq mESC enhancer starr_05673 Neighboring gene predicted gene 14041 Neighboring gene STARR-seq mESC enhancer starr_05675 Neighboring gene STARR-seq mESC enhancer starr_05676 Neighboring gene STARR-seq mESC enhancer starr_05677 Neighboring gene prodynorphin Neighboring gene STARR-seq mESC enhancer starr_05678 Neighboring gene STARR-seq mESC enhancer starr_05679 Neighboring gene peptidylprolyl isomerase A (Ppia) pseudogene 2_1620.1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis. Shen Q, et al. Front Immunol, 2022. PMID 35634325, Free PMC Article
  2. Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells. Ren B, et al. Elife, 2022 May 5. PMID 35511221, Free PMC Article
  3. Intratumoral SIRPα-deficient macrophages activate tumor antigen-specific cytotoxic T cells under radiotherapy. Bian Z, et al. Nat Commun, 2021 May 28. PMID 34050181, Free PMC Article
  4. Loss of microglial SIRPα promotes synaptic pruning in preclinical models of neurodegeneration. Ding X, et al. Nat Commun, 2021 Apr 1. PMID 33795678, Free PMC Article
  5. Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance. Gauttier V, et al. J Clin Invest, 2020 Nov 2. PMID 33074246, Free PMC Article

See all (207) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPalpha.
    Title: Surfactant protein D prevents mucin overproduction in airway goblet cells via SIRPα.
  2. SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
    Title: SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
  3. Blocking the CD47-SIRPalpha interaction reverses the disease phenotype in a polycythemia vera mouse model.
    Title: Blocking the CD47-SIRPα interaction reverses the disease phenotype in a polycythemia vera mouse model.
  4. Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
    Title: Neuronal signal-regulatory protein alpha drives microglial phagocytosis by limiting microglial interaction with CD47 in the retina.
  5. SIRPalpha maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
    Title: SIRPα maintains macrophage homeostasis by interacting with PTK2B kinase in Mycobacterium tuberculosis infection and through autophagy and necroptosis.
  6. SIRPalpha Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
    Title: SIRPα Mediates IGF1 Receptor in Cardiomyopathy Induced by Chronic Kidney Disease.
  7. Endothelial SIRPalpha signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
    Title: Endothelial SIRPα signaling controls VE-cadherin endocytosis for thymic homing of progenitor cells.
  8. SIRPalpha - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
    Title: SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen.
  9. Augmentation of CD47/SIRPalpha signaling protects cones in genetic models of retinal degeneration.
    Title: Augmentation of CD47/SIRPα signaling protects cones in genetic models of retinal degeneration.
  10. Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
    Title: Imaging of Glioblastoma Tumor-Associated Myeloid Cells Using Nanobodies Targeting Signal Regulatory Protein Alpha.
Submit: New GeneRIF Correction See all GeneRIFs (130)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables SH3 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables cell-cell adhesion mediator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein antigen binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding involved in heterotypic cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein phosphorylated amino acid binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell motility IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to hydrogen peroxide ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-1 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to interleukin-12 ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to lipopolysaccharide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to type II interferon ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytoskeleton organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in granulocyte migration IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within hematopoietic progenitor cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monocyte extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of I-kappaB phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of chemokine (C-C motif) ligand 5 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of macrophage inflammatory protein 1 alpha production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within phagocytosis, engulfment IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phagocytosis, recognition IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of nitric oxide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of tumor necrosis factor production ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of type II interferon production ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type substrate 1
Names
CD172 antigen-like family member A
SHP substrate 1
brain Ig-like molecule with tyrosine-based activation motifs
brain immunological-like with tyrosine-based motifs
inhibitory receptor SHPS-1
mSIRP-alpha1
myD-1 antigen
protein tyrosine phosphatase, non-receptor type substrate 1
signal-regulatory protein alpha-1
sirp-alpha-1
NP_001171118.1
NP_001277948.1
NP_001277949.1
NP_001277950.1
NP_001277951.1
NP_001342087.1
NP_001342089.1
NP_001407695.1
NP_001407696.1
NP_001407697.1
NP_001407698.1
NP_001407699.1
NP_001407700.1
NP_001407701.1
NP_031573.2
XP_017172053.1
XP_017172057.1
XP_017172058.1
XP_030104595.1
XP_030104598.1
XP_036015585.1
XP_036015587.1
XP_036015588.1
XP_036015589.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001177647.3 → NP_001171118.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001171118.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two alternate in-frame exons in the central coding region, and uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (2) is shorter than isoform 3.
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS50708.1
    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    A0A0R4J1Z7
    Related
    ENSMUSP00000125004.2, ENSMUST00000160276.2
    Conserved Domains (1) summary
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  2. NM_001291019.2 → NP_001277948.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277948.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript and encodes the longest isoform (3). Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS71142.1
    UniProtKB/Swiss-Prot
    A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
    UniProtKB/TrEMBL
    Q2M4I8
    Related
    ENSMUSP00000049022.8, ENSMUST00000049262.14
    Conserved Domains (4) summary
    cd00096
    Location:35 → 38
    Ig; Ig strand A [structural motif]
    cd05772
    Location:148 → 250
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:253 → 348
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  3. NM_001291020.2 → NP_001277949.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001277949.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 4. Both variants 4 and 5 encode isoform 3.
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS71142.1
    UniProtKB/Swiss-Prot
    A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
    UniProtKB/TrEMBL
    Q2M4I8
    Related
    ENSMUSP00000124048.2, ENSMUST00000161620.8
    Conserved Domains (4) summary
    cd00096
    Location:35 → 38
    Ig; Ig strand A [structural motif]
    cd05772
    Location:148 → 250
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:253 → 348
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  4. NM_001291021.2 → NP_001277950.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) lacks two alternate in-frame exons in the central coding region, compared to variant 4, resulting in an isoform (4) that is shorter than isoform 3. Variants 6 and 10 both encode the same isoform (4).
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS71143.1
    UniProtKB/TrEMBL
    E9QPT7
    Related
    ENSMUSP00000096713.4, ENSMUST00000099113.10
    Conserved Domains (1) summary
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  5. NM_001291022.2 → NP_001277951.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate in-frame exon in the 5' coding region and two in-frame exons in the central coding region, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 4. The encoded isoform (5) is shorter than isoform 3.
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS79845.1
    UniProtKB/TrEMBL
    E0CX65
    Related
    ENSMUSP00000124888.2, ENSMUST00000163034.8

  6. NM_001355158.2 → NP_001342087.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) encodes isoform 1. Variants 1, 8, 11, and 12 all encode the same isoform (1).
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS16729.1
    UniProtKB/TrEMBL
    Q2M4I8, Q6P6I8
    Related
    ENSMUSP00000137611.2, ENSMUST00000179001.8
    Conserved Domains (3) summary
    cd05772
    Location:148 → 251
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:253 → 356
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  7. NM_001355160.1 → NP_001342089.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL808126
    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (3) summary
    cd05772
    Location:136 → 239
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:241 → 344
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:23 → 134
    Ig; Immunoglobulin domain

  8. NM_001420766.1 → NP_001407695.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AL808126
    UniProtKB/Swiss-Prot
    A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4

  9. NM_001420767.1 → NP_001407696.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL808126
    UniProtKB/TrEMBL
    Q6P6I8

  10. NM_001420768.1 → NP_001407697.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    Status: VALIDATED

    Source sequence(s)
    AL808126
    UniProtKB/TrEMBL
    Q6P6I8

  11. NM_001420769.1 → NP_001407698.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AL808126

  12. NM_001420770.1 → NP_001407699.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AL808126

  13. NM_001420771.1 → NP_001407700.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AL808126

  14. NM_001420772.1 → NP_001407701.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 10

    Status: VALIDATED

    Source sequence(s)
    AL808126

  15. NM_007547.5 → NP_031573.2  tyrosine-protein phosphatase non-receptor type substrate 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_031573.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) uses an alternate in-frame splice site in the 3' coding region, compared to variant 4, resulting in an isoform (1) that is shorter than isoform 3. Variants 1, 8, 11, and 12 all encode the same isoform (1).
    Source sequence(s)
    AL808126
    Consensus CDS
    CCDS16729.1
    UniProtKB/TrEMBL
    Q2M4I8, Q6P6I8
    Related
    ENSMUSP00000099491.4, ENSMUST00000103202.10
    Conserved Domains (3) summary
    cd05772
    Location:148 → 251
    IgC_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2
    cd16085
    Location:253 → 356
    IgC_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    129432962..129474148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316564.2 → XP_017172053.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

  2. XM_036159695.1 → XP_036015588.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

  3. XM_017316568.2 → XP_017172057.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X5

    UniProtKB/TrEMBL
    E9QPT7
    Conserved Domains (1) summary
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  4. XM_017316569.2 → XP_017172058.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X6

    UniProtKB/Swiss-Prot
    P97797
    UniProtKB/TrEMBL
    A0A0R4J1Z7
    Conserved Domains (1) summary
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  5. XM_036159694.1 → XP_036015587.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

  6. XM_036159692.1 → XP_036015585.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X3

    UniProtKB/Swiss-Prot
    A0A0R4J1Z7, E0CYM8, E9QPT7, O08907, O35924, O88555, O88556, P97796, P97797, Q8R559, Q9QX57, Q9WTN4
    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:35 → 38
    Ig; Ig strand A [structural motif]
    cd05772
    Location:148 → 250
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:253 → 348
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:35 → 146
    Ig; Immunoglobulin domain

  7. XM_030248735.2 → XP_030104595.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X1

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

  8. XM_030248738.2 → XP_030104598.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

  9. XM_036159696.1 → XP_036015589.1  tyrosine-protein phosphatase non-receptor type substrate 1 isoform X2

    UniProtKB/TrEMBL
    Q2M4I8
    Conserved Domains (4) summary
    cd00096
    Location:28 → 31
    Ig; Ig strand A [structural motif]
    cd05772
    Location:141 → 243
    IgC1_SIRP_domain_2; Signal-regulatory protein (SIRP) immunoglobulin-like domain 2; member of the C1-set of Ig superfamily (IgSF) domains
    cd16085
    Location:246 → 341
    IgC1_SIRP_domain_3; Signal-regulatory protein (SIRP) immunoglobulin-like domain 3; member of the C1-set of Ig superfamily (IgSF) domains
    cl11960
    Location:28 → 139
    Ig; Immunoglobulin domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001177646.1: Suppressed sequence

    Description
    NM_001177646.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97797.2 GenPept UniProtKB/Swiss-Prot:P97797

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