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Ptpn20 protein tyrosine phosphatase, non-receptor type 20 [ Mus musculus (house mouse) ]

Gene ID: 19256, updated on 11-Apr-2024

Summary

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Official Symbol
Ptpn20provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 20provided by MGI
Primary source
MGI:MGI:1196295
See related
Ensembl:ENSMUSG00000021940 AllianceGenome:MGI:1196295
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
typ
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in centriolar satellite. Is expressed in epididymis; metanephros; submandibular gland; and testis. Orthologous to human PTPN20 (protein tyrosine phosphatase non-receptor type 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 17.2) See more
Orthologs
human all
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Genomic context

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See Ptpn20 in Genome Data Viewer
Location:
14 B; 14 20.51 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (33311150..33362711)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (33589193..33640754)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase 8 Neighboring gene STARR-seq mESC enhancer starr_36353 Neighboring gene FERM and PDZ domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_36354 Neighboring gene predicted gene, 26228 Neighboring gene STARR-seq mESC enhancer starr_36355 Neighboring gene STARR-seq mESC enhancer starr_36356 Neighboring gene RIKEN cDNA 4930503F20 gene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Molecular cloning and characterization of a novel cytoplasmic protein-tyrosine phosphatase that is specifically expressed in spermatocytes. Ohsugi M, et al. J Biol Chem, 1997 Dec 26. PMID 9407093
  2. Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study. Xu H, et al. Fluids Barriers CNS, 2022 Jun 3. PMID 35658898, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. BraInMap Elucidates the Macromolecular Connectivity Landscape of Mammalian Brain. Pourhaghighi R, et al. Cell Syst, 2020 Apr 22. PMID 32325033, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
    Title: Ptpn20 deletion in H-Tx rats enhances phosphorylation of the NKCC1 cotransporter in the choroid plexus: an evidence of genetic risk for hydrocephalus in an experimental study.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3) 
  • Endonuclease-mediated (5)  1 citation

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
NOT enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 20
Names
testis-specific tyrosine phosphatase
NP_033004.1
XP_006518791.1
XP_006518793.1
XP_011243298.1
XP_030103554.1
XP_030103555.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_008978.2 → NP_033004.1  tyrosine-protein phosphatase non-receptor type 20

    See identical proteins and their annotated locations for NP_033004.1

    Status: PROVISIONAL

    Source sequence(s)
    AC154465
    Consensus CDS
    CCDS36870.1
    UniProtKB/Swiss-Prot
    A4QPF6, O55082
    Related
    ENSMUSP00000022508.7, ENSMUST00000022508.8
    Conserved Domains (2) summary
    smart00194
    Location:165 → 417
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:191 → 417
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    33311150..33362711
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006518728.4 → XP_006518791.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

    See identical proteins and their annotated locations for XP_006518791.1

    Conserved Domains (1) summary
    cl28904
    Location:251 → 457
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_011244996.3 → XP_011243298.1  tyrosine-protein phosphatase non-receptor type 20 isoform X2

    Conserved Domains (1) summary
    smart00194
    Location:202 → 240
    PTPc; Protein tyrosine phosphatase, catalytic domain

  3. XM_030247694.2 → XP_030103554.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:23 → 130
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_006518730.1 → XP_006518793.1  tyrosine-protein phosphatase non-receptor type 20 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:40 → 246
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_030247695.1 → XP_030103555.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:23 → 130
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_383149.4 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O55082.1 GenPept UniProtKB/Swiss-Prot:O55082

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