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Ptpn18 protein tyrosine phosphatase, non-receptor type 18 [ Mus musculus (house mouse) ]

Gene ID: 19253, updated on 11-Apr-2024

Summary

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Official Symbol
Ptpn18provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 18provided by MGI
Primary source
MGI:MGI:108410
See related
Ensembl:ENSMUSG00000026126 AllianceGenome:MGI:108410
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FLP1; HSCF; FLP-1; Ptpk1; PTP-K1; PTP-HSCF
Summary
Enables non-membrane spanning protein tyrosine phosphatase activity. Acts upstream of or within blastocyst formation. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human PTPN18 (protein tyrosine phosphatase non-receptor type 18). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 76.4), duodenum adult (RPKM 74.3) and 13 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 B; 1 13.25 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (34498827..34514811)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (34459729..34473784)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E787 Neighboring gene coiled-coil domain containing 115 Neighboring gene IMP4, U3 small nucleolar ribonucleoprotein Neighboring gene STARR-positive B cell enhancer mm9_chr1:34519657-34519958 Neighboring gene predicted gene, 32504 Neighboring gene predicted gene 28417 Neighboring gene RIKEN cDNA 4930568A12 gene Neighboring gene predicted gene, 32566 Neighboring gene serine protease 39

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Cloning and characterization of fetal liver phosphatase 1, a nuclear protein tyrosine phosphatase isolated from hematopoietic stem cells. Dosil M, et al. Blood, 1996 Dec 15. PMID 8977243
  2. A novel protein tyrosine phosphatase expressed in lin(lo)CD34(hi)Sca(hi) hematopoietic progenitor cells. Cheng J, et al. Blood, 1996 Aug 15. PMID 8695832
  3. Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1. Gensler M, et al. J Biol Chem, 2004 Mar 26. PMID 14660651
  4. PSTPIP: a tyrosine phosphorylated cleavage furrow-associated protein that is a substrate for a PEST tyrosine phosphatase. Spencer S, et al. J Cell Biol, 1997 Aug 25. PMID 9265651, Free PMC Article
  5. SH2 domain-mediated interaction of inhibitory protein tyrosine kinase Csk with protein tyrosine phosphatase-HSCF. Wang B, et al. Mol Cell Biol, 2001 Feb. PMID 11158295, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BDP1 has a role in negative regulation of HER2 signaling
    Title: Negative regulation of HER2 signaling by the PEST-type protein-tyrosine phosphatase BDP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blastocyst formation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein phosphatase non-receptor type 18
Names
fetal liver phosphatase 1
NP_001407402.1
NP_001407403.1
NP_035336.2
XP_036018686.1
XP_036018687.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001420473.1 → NP_001407402.1  tyrosine-protein phosphatase non-receptor type 18 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC106841

  2. NM_001420474.1 → NP_001407403.1  tyrosine-protein phosphatase non-receptor type 18 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC106841

  3. NM_011206.2 → NP_035336.2  tyrosine-protein phosphatase non-receptor type 18 isoform 1

    See identical proteins and their annotated locations for NP_035336.2

    Status: VALIDATED

    Source sequence(s)
    AK144353, CD740968, CJ166432
    Consensus CDS
    CCDS14867.1
    UniProtKB/Swiss-Prot
    Q4JFH4, Q61152, Q62404, Q922E3
    Related
    ENSMUSP00000027302.8, ENSMUST00000027302.14
    Conserved Domains (2) summary
    cd00047
    Location:59 → 290
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam00102
    Location:56 → 290
    Y_phosphatase; Protein-tyrosine phosphatase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    34498827..34514811
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162793.1 → XP_036018686.1  tyrosine-protein phosphatase non-receptor type 18 isoform X1

    Conserved Domains (2) summary
    PRK14951
    Location:331 → 428
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cl28904
    Location:27 → 292
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_036162794.1 → XP_036018687.1  tyrosine-protein phosphatase non-receptor type 18 isoform X3

    Conserved Domains (2) summary
    PRK14951
    Location:299 → 420
    PRK14951; DNA polymerase III subunits gamma and tau; Provisional
    cl28904
    Location:27 → 260
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q61152.1 GenPept UniProtKB/Swiss-Prot:Q61152

Gene LinkOut

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