U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [ Mus musculus (house mouse) ]

Gene ID: 19248, updated on 11-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ptpn12provided by MGI
Official Full Name
protein tyrosine phosphatase, non-receptor type 12provided by MGI
Primary source
MGI:MGI:104673
See related
Ensembl:ENSMUSG00000028771 AllianceGenome:MGI:104673
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PTPG1; P19-PTP; PTP-P19; PTP-PEST
Summary
Enables phosphoprotein phosphatase activity. Acts upstream of or within protein dephosphorylation. Located in cytosol and podosome. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; gut; and retina. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E14 (RPKM 8.7), CNS E18 (RPKM 8.5) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Ptpn12 in Genome Data Viewer
Location:
5 A3; 5 9.83 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (21191643..21261009, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (20986645..21055911, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_12554 Neighboring gene transmembrane protein 60 Neighboring gene round spermatid basic protein 1-like Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:20447096-20447297 Neighboring gene STARR-seq mESC enhancer starr_12555 Neighboring gene RIKEN cDNA A630072M18 gene Neighboring gene STARR-seq mESC enhancer starr_12556 Neighboring gene STARR-seq mESC enhancer starr_12557 Neighboring gene STARR-seq mESC enhancer starr_12559 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20484581-20484882 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20508606-20508906 Neighboring gene STARR-positive B cell enhancer ABC_E10306 Neighboring gene STARR-seq mESC enhancer starr_12560 Neighboring gene STARR-positive B cell enhancer mm9_chr5:20561662-20561962 Neighboring gene STARR-seq mESC enhancer starr_12561 Neighboring gene predicted gene, 42221 Neighboring gene predicted gene, 22490

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells. Rhee I, et al. Mol Cell Biol, 2014 Mar. PMID 24366546, Free PMC Article
  2. TCR-induced downregulation of protein tyrosine phosphatase PEST augments secondary T cell responses. Arimura Y, et al. Mol Immunol, 2008 Jun. PMID 18457880, Free PMC Article
  3. Structure of the murine MPTP-PEST gene: genomic organization and chromosomal mapping. Charest A, et al. Genomics, 1995 Aug 10. PMID 7490087
  4. Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition. Li J, et al. Mol Cell Biol, 2015 Dec. PMID 26391955, Free PMC Article
  5. Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation. Zhang P, et al. J Immunol, 2013 Feb 15. PMID 23296707

See all (57) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties.
    Title: Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.
  2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1.
    Title: Protein tyrosine phosphatase-PEST and β8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells.
  3. Pyk2 deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency.
    Title: Control of dendritic cell migration, T cell-dependent immunity, and autoimmunity by protein tyrosine phosphatase PTPN12 expressed in dendritic cells.
  4. Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
    Title: Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility.
  5. macrophage fusion is critically dependent on PTP-PEST.
    Title: Macrophage fusion is controlled by the cytoplasmic protein tyrosine phosphatase PTP-PEST/PTPN12.
  6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS)-induced tyrosine phosphorylation of IkappaB kinase (IKKbeta) at Tyr188/199 in RAW264.7 cells.
    Title: Protein tyrosine phosphatase with proline-glutamine-serine-threonine-rich motifs negatively regulates TLR-triggered innate responses by selectively inhibiting IκB kinase β/NF-κB activation.
  7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells.
    Title: The phosphatase PTP-PEST/PTPN12 regulates endothelial cell migration and adhesion, but not permeability, and controls vascular development and embryonic viability.
  8. the dephosphorylation of Pyk2 requires dynamin's GTPase activity and is mediated by the tyrosine phosphatase PTP-PEST.
    Title: Dynamin and PTP-PEST cooperatively regulate Pyk2 dephosphorylation in osteoclasts.
  9. PTP-PEST controls Pyk2 activity and is a positive regulator of secondary T cell activation.
    Title: The phosphatase PTP-PEST promotes secondary T cell responses by dephosphorylating the protein tyrosine kinase Pyk2.
  10. Data show that ERK phosphorylates FAK S910 and recruits PIN1 and PTP-PEST, which colocalize with FAK at the lamellipodia of migrating cells.
    Title: FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (6)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH3 domain binding ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables non-membrane spanning protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphoprotein phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein dephosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of epidermal growth factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in podosome IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
tyrosine-protein phosphatase non-receptor type 12
Names
MPTP-PEST
protein-tyrosine phosphatase P19
NP_001343519.1
NP_001343520.1
NP_001343521.1
NP_001411448.1
NP_001411450.1
NP_035333.2
XP_030110077.1
XP_036020804.1
XP_036020805.1
XP_036020806.1
XP_036020807.1
XP_036020808.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356590.1 → NP_001343519.1  tyrosine-protein phosphatase non-receptor type 12 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC116501, AC121572
    Conserved Domains (1) summary
    cl28904
    Location:43 → 312
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. NM_001356591.2 → NP_001343520.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC116501, AC121572
    Conserved Domains (1) summary
    cl28904
    Location:1 → 179
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. NM_001356592.1 → NP_001343521.1  tyrosine-protein phosphatase non-receptor type 12 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a. Variants 3 and 4 both encode the same isoform (c).
    Source sequence(s)
    AC116501, AC121572
    Conserved Domains (1) summary
    cl28904
    Location:1 → 179
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. NM_001424519.1 → NP_001411448.1  tyrosine-protein phosphatase non-receptor type 12 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC116501, AC121572

  5. NM_001424521.1 → NP_001411450.1  tyrosine-protein phosphatase non-receptor type 12 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC116501, AC121572

  6. NM_011203.4 → NP_035333.2  tyrosine-protein phosphatase non-receptor type 12 isoform b

    See identical proteins and their annotated locations for NP_035333.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AC116501, AC121572
    Consensus CDS
    CCDS19102.1
    UniProtKB/Swiss-Prot
    P35831, Q80UM4
    Related
    ENSMUSP00000030556.8, ENSMUST00000030556.8
    Conserved Domains (2) summary
    smart00194
    Location:28 → 292
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:60 → 292
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    21191643..21261009 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036164914.1 → XP_036020807.1  tyrosine-protein phosphatase non-receptor type 12 isoform X4

    Conserved Domains (1) summary
    cl28904
    Location:1 → 179
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  2. XM_036164915.1 → XP_036020808.1  tyrosine-protein phosphatase non-receptor type 12 isoform X5

    Conserved Domains (1) summary
    cl28904
    Location:1 → 87
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  3. XM_036164912.1 → XP_036020805.1  tyrosine-protein phosphatase non-receptor type 12 isoform X2

    Conserved Domains (1) summary
    cl28904
    Location:43 → 312
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  4. XM_036164911.1 → XP_036020804.1  tyrosine-protein phosphatase non-receptor type 12 isoform X1

    Conserved Domains (1) summary
    cl28904
    Location:43 → 312
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  5. XM_036164913.1 → XP_036020806.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 179
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

  6. XM_030254217.2 → XP_030110077.1  tyrosine-protein phosphatase non-receptor type 12 isoform X3

    Conserved Domains (1) summary
    cl28904
    Location:1 → 179
    PTP_DSP_cys; cys-based protein tyrosine phosphatase and dual-specificity phosphatase superfamily

RNA

  1. XR_004942461.1 RNA Sequence

  2. XR_004942460.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P35831.3 GenPept UniProtKB/Swiss-Prot:P35831

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous