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Ptp4a2 protein tyrosine phosphatase 4a2 [ Mus musculus (house mouse) ]

Gene ID: 19244, updated on 21-Apr-2024

Summary

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Official Symbol
Ptp4a2provided by MGI
Official Full Name
protein tyrosine phosphatase 4a2provided by MGI
Primary source
MGI:MGI:1277117
See related
Ensembl:ENSMUSG00000028788 AllianceGenome:MGI:1277117
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Prl-2
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Predicted to be located in endosome and plasma membrane. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human PTP4A2 (protein tyrosine phosphatase 4A2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 35.0), CNS E11.5 (RPKM 30.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 63.38 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129704982..129743800)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129811165..129850003)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene STARR-seq mESC enhancer starr_11505 Neighboring gene STARR-seq mESC enhancer starr_11507 Neighboring gene STARR-positive B cell enhancer mm9_chr4:129438194-129438495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129439040-129439227 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129449340-129449541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129449548-129449839 Neighboring gene predicted gene 12967 Neighboring gene STARR-positive B cell enhancer ABC_E4671 Neighboring gene STARR-seq mESC enhancer starr_11508 Neighboring gene STARR-positive B cell enhancer ABC_E2715 Neighboring gene STARR-seq mESC enhancer starr_11510 Neighboring gene STARR-positive B cell enhancer ABC_E11257 Neighboring gene STARR-positive B cell enhancer ABC_E6225 Neighboring gene STARR-seq mESC enhancer starr_11511 Neighboring gene RIKEN cDNA 1700108I11 gene Neighboring gene STARR-positive B cell enhancer ABC_E7993 Neighboring gene STARR-positive B cell enhancer ABC_E6226 Neighboring gene predicted gene, 23845

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling. Poulet M, et al. Commun Biol, 2020 Oct 23. PMID 33097786, Free PMC Article
  2. PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS. Yin C, et al. Front Immunol, 2018. PMID 30483267, Free PMC Article
  3. PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal. Kobayashi M, et al. Stem Cells, 2014 Jul. PMID 24753135, Free PMC Article
  4. PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805. Bai Y, et al. Autophagy, 2023 May. PMID 36300783, Free PMC Article
  5. Role of phosphatase of regenerating liver 1 (PRL1) in spermatogenesis. Bai Y, et al. Sci Rep, 2016 Sep 26. PMID 27666520, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.
    Title: PRL2 regulates neutrophil extracellular trap formation which contributes to severe malaria and acute lung injury.
  2. PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
    Title: PRL2 Phosphatase Promotes Oncogenic KIT Signaling in Leukemia Cells through Modulating CBL Phosphorylation.
  3. CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.
    Title: CircPTP4A2 Promotes Microglia Polarization in Cerebral Ischemic Stroke via miR-20b-5p/YTHDF1/TIMP2 Axis.
  4. PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
    Title: PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805.
  5. PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.
    Title: PRL-2 phosphatase is required for vascular morphogenesis and angiogenic signaling.
  6. Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
    Title: Mechanism of PRL2 phosphatase-mediated PTEN degradation and tumorigenesis.
  7. PRL2 binds to GTPase Rac.
    Title: PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS.
  8. a critical role for PRL2 phosphatase in mediating Notch and c-Kit signals in early T cell progenitors, is reported.
    Title: Protein Tyrosine Phosphatase PRL2 Mediates Notch and Kit Signals in Early T Cell Progenitors.
  9. Oncogenic PRL-2 controls tumor growth by modulating intracellular magnesium levels through binding with the CNNM3 magnesium transporter.
    Title: The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis.
  10. PTP4A2 plays critical roles in regulating hematopoietic stem cell self-renewal and mediating SCF/KIT signaling.
    Title: PRL2/PTP4A2 phosphatase is important for hematopoietic stem cell self-renewal.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Targeted (2)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC102154, MGC103400

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endosome IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein tyrosine phosphatase type IVA 2
Names
protein-tyrosine phosphatase of regenerating liver 2
NP_001158217.1
NP_001411752.1
NP_001411753.1
NP_001411754.1
NP_001411755.1
NP_001411756.1
NP_033000.1
XP_017175534.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001164745.2 → NP_001158217.1  protein tyrosine phosphatase type IVA 2 isoform 1

    See identical proteins and their annotated locations for NP_001158217.1

    Status: VALIDATED

    Source sequence(s)
    AL669834
    Consensus CDS
    CCDS18704.1
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    Q3UXF9
    Related
    ENSMUSP00000125901.2, ENSMUST00000165853.2
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

  2. NM_001424823.1 → NP_001411752.1  protein tyrosine phosphatase type IVA 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL669834
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7

  3. NM_001424824.1 → NP_001411753.1  protein tyrosine phosphatase type IVA 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL669834
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7

  4. NM_001424825.1 → NP_001411754.1  protein tyrosine phosphatase type IVA 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669834

  5. NM_001424826.1 → NP_001411755.1  protein tyrosine phosphatase type IVA 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL669834

  6. NM_001424827.1 → NP_001411756.1  protein tyrosine phosphatase type IVA 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL669834

  7. NM_008974.5 → NP_033000.1  protein tyrosine phosphatase type IVA 2 isoform 1

    See identical proteins and their annotated locations for NP_033000.1

    Status: VALIDATED

    Source sequence(s)
    AL669834
    Consensus CDS
    CCDS18704.1
    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    Q3UXF9
    Related
    ENSMUSP00000030578.8, ENSMUST00000030578.14
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2

RNA

  1. NR_188949.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669834

  2. NR_188950.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669834

  3. NR_188951.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL669834

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    129704982..129743800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017320045.3 → XP_017175534.1  protein tyrosine phosphatase type IVA 2 isoform X1

    UniProtKB/Swiss-Prot
    O70274, Q3U1K7
    UniProtKB/TrEMBL
    Q3UXF9
    Conserved Domains (1) summary
    cd18536
    Location:1 → 155
    PTP-IVa2; protein tyrosine phosphatase type IVA 2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O70274.1 GenPept UniProtKB/Swiss-Prot:O70274

Gene LinkOut

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