Nrbp1 nuclear receptor binding protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nrbp1provided by MGI
Official Full Name: nuclear receptor binding protein 1provided by MGI
Primary source: MGI:MGI:2183436
See related: Ensembl:ENSMUSG00000029148 AllianceGenome:MGI:2183436
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Nrbp; B230344L17Rik
Summary: Enables protein homodimerization activity. Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport and intracellular signal transduction. Located in perinuclear region of cytoplasm. Is expressed in cap mesenchyme; ovary; and renal interstitium. Orthologous to human NRBP1 (nuclear receptor binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 58.6), duodenum adult (RPKM 52.1) and 28 other tissues See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 5 B1; 5 17.27 cM

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (31398227..31408910)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (31228089..31251566)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
Title: The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.
Using a novel combination of RNAi screens in worms together with detailed follow-up experiments in mouse and human cells, it was shown that NRBP1 is a tumour suppressor that plays a critical role in intestinal cell homoeostasis.
Title: Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (1)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Nrbp1 (e-PCR), detects polymorphism
- UniSTS:527463

NoName (e-PCR)
- UniSTS:235158

D2S1725E (e-PCR)
- UniSTS:150754

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
NOT enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
NOT enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	ISO Inferred from Sequence Orthology more info	PubMed

Process	Evidence Code	Pubs
NOT acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info	PubMed
involved_in endoplasmic reticulum to Golgi vesicle-mediated transport	ISO Inferred from Sequence Orthology more info
involved_in epithelial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in in utero embryonic development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in endomembrane system	IBA Inferred from Biological aspect of Ancestor more info
located_in endomembrane system	ISO Inferred from Sequence Orthology more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: nuclear receptor-binding protein

Names: HLS7-interacting protein kinase; MLF1 adapter molecule

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001347326.1 → NP_001334255.1 nuclear receptor-binding protein isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AC114619

Consensus CDS

CCDS84863.1

UniProtKB/TrEMBL

D3YUV1, Q3TCW5

Related

ENSMUSP00000143872.2, ENSMUST00000202576.4
NM_147201.2 → NP_671734.1 nuclear receptor-binding protein isoform 2

See identical proteins and their annotated locations for NP_671734.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.

Source sequence(s)

AC114619

Consensus CDS

CCDS19180.1

UniProtKB/Swiss-Prot

Q8BL77, Q99J45

UniProtKB/TrEMBL

Q3TCW5

Related

ENSMUSP00000031034.6, ENSMUST00000031034.12

Conserved Domains (2) summary

smart00220
Location:83 → 325

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14034
Location:60 → 334

PK_NRBP1; Pseudokinase domain of Nuclear Receptor Binding Protein 1