Ptgs2 prostaglandin-endoperoxide synthase 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ptgs2provided by MGI
Official Full Name: prostaglandin-endoperoxide synthase 2provided by MGI
Primary source: MGI:MGI:97798
See related: Ensembl:ENSMUSG00000032487 AllianceGenome:MGI:97798
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: COX2; Cox-2; PES-2; PHS-2; Pghs2; TIS10; PGHS-2; PHS II; gripghs
Summary: This gene encodes an enzyme that is a member of the prostaglandin G/H synthase family. The encoded protein converts arachidonic acid to prostaglandin endoperoxide H2 which is a key enzymatic step in prostaglandin biosynthesis. This gene is the inducible prostaglandin G/H synthase family member that is upregulated during inflammation. Aberrant regulation of this gene is associated with cancer progression in several tissues and an increased risk of cardiovascular events. This gene is the target of many non-steroidal anti-inflammatory drugs. [provided by RefSeq, Sep 2015]
Expression: Biased expression in genital fat pad adult (RPKM 14.2), bladder adult (RPKM 2.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 G1; 1 63.84 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (149975851..149983978)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (150100031..150108234)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PTGS2: A potential immune regulator and therapeutic target for chronic spontaneous urticaria.
Title: PTGS2: A potential immune regulator and therapeutic target for chronic spontaneous urticaria.
Abnormal Microglial Density and Morphology in the Brain of Cyclooxygenase 2 Knockin Mice.
Title: Abnormal Microglial Density and Morphology in the Brain of Cyclooxygenase 2 Knockin Mice.
Genetic model of selective COX2 inhibition improve learning and memory ability and brain pathological changes in 5xFAD mouse.
Title: Genetic model of selective COX2 inhibition improve learning and memory ability and brain pathological changes in 5xFAD mouse.
Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia.
Title: Decreased cyclooxygenase-2 associated with impaired megakaryopoiesis and thrombopoiesis in primary immune thrombocytopenia.
Essential genes Ptgs2, Tlr4, and Ccr2 regulate neuro-inflammation during the acute phase of cerebral ischemic in mice.
Title: Essential genes Ptgs2, Tlr4, and Ccr2 regulate neuro-inflammation during the acute phase of cerebral ischemic in mice.
Neutrophil-Derived COX-2 has a Key Role during Inflammatory Hyperalgesia.
Title: Neutrophil-Derived COX-2 has a Key Role during Inflammatory Hyperalgesia.
DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.
Title: DCLK1 promotes colorectal cancer stemness and aggressiveness via the XRCC5/COX2 axis.
Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP2 receptor upregulation in mouse and human kidney.
Title: Increased COX-2 after ureter obstruction attenuates fibrosis and is associated with EP(2) receptor upregulation in mouse and human kidney.
COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity.
Title: COX-2 Deficiency Promotes White Adipogenesis via PGE2-Mediated Paracrine Mechanism and Exacerbates Diet-Induced Obesity.
Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.
Title: Downregulation of LHCGR Attenuates COX-2 Expression and Induces Luteinized Unruptured Follicle Syndrome in Endometriosis.

Submit: New GeneRIF Correction See all GeneRIFs (663)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (16) 1 citation
Endonuclease-mediated (8) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC27868P2 (e-PCR)
- UniSTS:272389

M88242 (e-PCR)
- UniSTS:178476

PMC18294P1 (e-PCR)
- UniSTS:271683

Ptgs2 (e-PCR), detects polymorphism
- UniSTS:254306

PMC14708P2 (e-PCR)
- UniSTS:271010

PMC148819P3 (e-PCR)
- UniSTS:271016

NoName (e-PCR)
- UniSTS:224190

Ptgs2 (e-PCR), detects polymorphism
- UniSTS:256486

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables dioxygenase activity	IEA Inferred from Electronic Annotation more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables heme binding	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	IBA Inferred from Biological aspect of Ancestor more info
enables oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info
enables prostaglandin-endoperoxide synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables prostaglandin-endoperoxide synthase activity	IDA Inferred from Direct Assay more info	PubMed
enables prostaglandin-endoperoxide synthase activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within anagen	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within bone mineralization	ISO Inferred from Sequence Orthology more info	PubMed
involved_in brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to fluid shear stress	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to non-ionic osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclooxygenase pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cyclooxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cyclooxygenase pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cyclooxygenase pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within decidualization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in decidualization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryo implantation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo implantation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in learning	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in maintenance of blood-brain barrier	ISO Inferred from Sequence Orthology more info
involved_in memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of synaptic transmission, dopaminergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of brown fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fever generation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fever generation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fibroblast growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of nitric oxide biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of platelet-derived growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of prostaglandin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of smooth muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of synaptic transmission, glutamatergic	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in prostaglandin biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in prostaglandin biosynthetic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within prostaglandin secretion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of neuroinflammatory response	IDA Inferred from Direct Assay more info	PubMed
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
colocalizes_with caveola	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info	PubMed
located_in nuclear inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear inner membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear outer membrane	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: prostaglandin G/H synthase 2

Names: PGH synthase 2; cyclooxygenase-2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin H2 synthase 2

NP_035328.2

EC 1.14.99.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_011198.5 → NP_035328.2 prostaglandin G/H synthase 2 precursor

See identical proteins and their annotated locations for NP_035328.2

Status: VALIDATED

Source sequence(s)

AC114655

Consensus CDS

CCDS15353.1

UniProtKB/Swiss-Prot

Q05769, Q543K3

UniProtKB/TrEMBL

Q3UMR6

Related

ENSMUSP00000035065.8, ENSMUST00000035065.9

Conserved Domains (2) summary

cd09816
Location:75 → 562

prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins

cd00054
Location:19 → 55

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...