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Ptgfrn prostaglandin F2 receptor negative regulator [ Mus musculus (house mouse) ]

Gene ID: 19221, updated on 11-Apr-2024

Summary

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Official Symbol
Ptgfrnprovided by MGI
Official Full Name
prostaglandin F2 receptor negative regulatorprovided by MGI
Primary source
MGI:MGI:1277114
See related
Ensembl:ENSMUSG00000027864 AllianceGenome:MGI:1277114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
FPRP; EWI-F; CD9P-1; Trim45; 4833445A08Rik
Summary
Involved in myoblast fusion involved in skeletal muscle regeneration. Acts upstream of or within lipid droplet organization. Predicted to be located in Golgi apparatus; endoplasmic reticulum; and membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; glans of male genital tubercle; skeleton; and vibrissa. Orthologous to human PTGFRN (prostaglandin F2 receptor inhibitor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 30.6), bladder adult (RPKM 17.8) and 21 other tissues See more
Orthologs
human all
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Genomic context

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See Ptgfrn in Genome Data Viewer
Location:
3 F2.2; 3 43.93 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (100947546..101018061, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101040230..101110745, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2678 Neighboring gene transcription termination factor, RNA polymerase II Neighboring gene CD101 antigen Neighboring gene STARR-seq mESC enhancer starr_08505 Neighboring gene STARR-seq mESC enhancer starr_08514 Neighboring gene STARR-seq mESC enhancer starr_08516 Neighboring gene STARR-seq mESC enhancer starr_08517 Neighboring gene STARR-seq mESC enhancer starr_08518 Neighboring gene nuclear import 7 pseudogene Neighboring gene tumor protein, translationally-controlled, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The Ig domain protein CD9P-1 down-regulates CD81 ability to support Plasmodium yoelii infection. Charrin S, et al. J Biol Chem, 2009 Nov 13. PMID 19762465, Free PMC Article
  2. The monoclonal antibodies 18d7/91f2 recognize a receptor regulatory protein on mouse bone marrow stromal cells. Weng L, et al. J Bone Miner Res, 2000 Jul. PMID 10893677
  3. Cloning, sequencing and proposed structure for a prostaglandin F2 alpha receptor regulatory protein. Orlicky DJ, et al. Prostaglandins Leukot Essent Fatty Acids, 1996 Oct. PMID 8951995
  4. Synthesis and accumulation of a receptor regulatory protein associated with lipid droplet accumulation in 3T3-L1 cells. Orlicky DJ, et al. J Lipid Res, 1998 Jun. PMID 9643346
  5. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins. Sala-Valdés M, et al. J Biol Chem, 2006 Jul 14. PMID 16690612

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins
    Title: EWI-2 and EWI-F link the tetraspanin web to the actin cytoskeleton through their direct association with ezrin-radixin-moesin proteins.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid droplet organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in myoblast fusion involved in skeletal muscle regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
prostaglandin F2 receptor negative regulator
Names
CD9 partner 1
glu-Trp-Ile EWI motif-containing protein F
prostaglandin F2-alpha receptor regulatory protein
prostaglandin F2-alpha receptor-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011197.3 → NP_035327.2  prostaglandin F2 receptor negative regulator precursor

    See identical proteins and their annotated locations for NP_035327.2

    Status: VALIDATED

    Source sequence(s)
    AL645930, AL669872
    Consensus CDS
    CCDS17680.1
    UniProtKB/Swiss-Prot
    Q5SRA8, Q9WV91
    UniProtKB/TrEMBL
    Q69ZJ6
    Related
    ENSMUSP00000099755.4, ENSMUST00000102694.4
    Conserved Domains (3) summary
    smart00406
    Location:39 → 121
    IGv; Immunoglobulin V-Type
    smart00410
    Location:29 → 140
    IG_like; Immunoglobulin like
    cl11960
    Location:283 → 375
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    100947546..101018061 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319503.2 → XP_017174992.1  prostaglandin F2 receptor negative regulator isoform X1

    UniProtKB/TrEMBL
    Q69ZJ6
    Conserved Domains (2) summary
    smart00406
    Location:36 → 118
    IGv; Immunoglobulin V-Type
    smart00409
    Location:281 → 372
    IG; Immunoglobulin

  2. XM_006501147.4 → XP_006501210.1  prostaglandin F2 receptor negative regulator isoform X2

    See identical proteins and their annotated locations for XP_006501210.1

    UniProtKB/TrEMBL
    Q69ZJ6
    Conserved Domains (2) summary
    smart00406
    Location:27 → 109
    IGv; Immunoglobulin V-Type
    smart00409
    Location:272 → 363
    IG; Immunoglobulin
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9WV91.2 GenPept UniProtKB/Swiss-Prot:Q9WV91

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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