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Rspo1 R-spondin 1 [ Mus musculus (house mouse) ]

Gene ID: 192199, updated on 21-Apr-2024

Summary

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Official Symbol
Rspo1provided by MGI
Official Full Name
R-spondin 1provided by MGI
Primary source
MGI:MGI:2183426
See related
Ensembl:ENSMUSG00000028871 AllianceGenome:MGI:2183426
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rspondin; R-spondin
Summary
Enables heparin binding activity and signaling receptor binding activity. Involved in positive regulation of canonical Wnt signaling pathway. Acts upstream of or within several processes, including male meiotic nuclear division; positive regulation of non-canonical Wnt signaling pathway; and regulation of male germ cell proliferation. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and skeleton. Orthologous to human RSPO1 (R-spondin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in ovary adult (RPKM 13.8), CNS E11.5 (RPKM 10.5) and 19 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 57.96 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (124880197..124902895)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (124986401..125009102)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E424 Neighboring gene STARR-positive B cell enhancer ABC_E4665 Neighboring gene AFG2 interacting ribosome maturation factor Neighboring gene predicted gene 12930 Neighboring gene predicted gene, 32371 Neighboring gene predicted gene, 38472 Neighboring gene STARR-positive B cell enhancer ABC_E7987 Neighboring gene guanine nucleotide binding protein nucleolar 2 Neighboring gene dynein, axonemal, light intermediate polypeptide 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway. Su X, et al. Exp Cell Res, 2021 Aug 15. PMID 34181940
  2. R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways. Lacour F, et al. Cell Rep, 2017 Mar 7. PMID 28273449, Free PMC Article
  3. Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy. Chadi S, et al. PLoS One, 2016. PMID 27611670, Free PMC Article
  4. R-spondin1 is a novel hormone mediator for mammary stem cell self-renewal. Cai C, et al. Genes Dev, 2014 Oct 15. PMID 25260709, Free PMC Article
  5. R-spondin1 deficiency enhances β-Cell neogenesis in a murine model of diabetes. Chahal JK, et al. Pancreas, 2014 Jan. PMID 24263108

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
    Title: Rspo1 and Rspo3 are required for sensory lineage neural crest formation in mouse embryos.
  2. Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/beta-catenin pathway.
    Title: Silencing of RSPO1 mitigates obesity-related renal fibrosis in mice by deactivating Wnt/β-catenin pathway.
  3. R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.
    Title: R-spondin substitutes for neuronal input for taste cell regeneration in adult mice.
  4. Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKalpha-SREBP2 pathway.
    Title: Rspo1/Rspo3-LGR4 signaling inhibits hepatic cholesterol synthesis through the AMPKα-SREBP2 pathway.
  5. A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/beta-catenin signaling.
    Title: A novel function of R-spondin1 in regulating estrogen receptor expression independent of Wnt/β-catenin signaling.
  6. Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland.
    Title: Amphiregulin mediates the hormonal regulation on Rspondin-1 expression in the mammary gland.
  7. the Rspo3-Lgr5 axis simultaneously regulates both antimicrobial defence and mucosal regeneration
    Title: R-spondin-3 induces secretory, antimicrobial Lgr5(+) cells in the stomach.
  8. blocking Rspo-Lgr4 signaling overcame Lewis lung carcinoma (LLC) resistance to anti-PD-1 therapy and improved the efficacy of PD-1 immunotherapy against B16F10 melanoma, indicating vital roles of Rspo-Lgr4 in host antitumor immunity and a potential therapeutic target in cancer immunotherapy.
    Title: Inhibition of Rspo-Lgr4 Facilitates Checkpoint Blockade Therapy by Switching Macrophage Polarization.
  9. reciprocal control of antagonistic Wnt signaling pathways by Rspo1 in muscle stem cell progeny is a key step ensuring normal tissue architecture restoration following acute damage.
    Title: R-spondin1 Controls Muscle Cell Fusion through Dual Regulation of Antagonistic Wnt Signaling Pathways.
  10. In Rspo1 knock-out mice during pregnancy, a stronger expression of mesenchymal markers was observed, without modifications to the structure of mammary epithelial tissue. Mammary epithelial cell immunohistochemical analysis revealed a persistence of virgin markers, which signify a delay in cell differentiation.
    Title: Phenotypic and Molecular Alterations in the Mammary Tissue of R-Spondin1 Knock-Out Mice during Pregnancy.
Submit: New GeneRIF Correction See all GeneRIFs (43)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (3) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor binding ISO
Inferred from Sequence Orthology
more info
  
enables heparin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within male meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of non-canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of receptor internalization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within response to stimulus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
R-spondin-1
Names
R-spondin homolog
cristin-3
cysteine-rich and single thrombospondin domain-containing protein 3
mCristin-3
roof plate-specific spondin-1
thrombospondin type 1 domain containing gene Rspondin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_138683.2 → NP_619624.2  R-spondin-1 precursor

    See identical proteins and their annotated locations for NP_619624.2

    Status: VALIDATED

    Source sequence(s)
    AB016768, AK132277
    Consensus CDS
    CCDS18633.1
    UniProtKB/Swiss-Prot
    Q3V1S3, Q9Z132
    UniProtKB/TrEMBL
    B1ASC1
    Related
    ENSMUSP00000030687.8, ENSMUST00000030687.8
    Conserved Domains (3) summary
    cd00064
    Location:100 → 142
    FU; Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.
    pfam15913
    Location:42 → 144
    Furin-like_2; Furin-like repeat, cysteine-rich
    cl15278
    Location:151 → 208
    TSP_1; Thrombospondin type 1 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    124880197..124902895
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502862.4 → XP_006502925.1  R-spondin-1 isoform X1

    Conserved Domains (2) summary
    PTZ00441
    Location:89 → 143
    PTZ00441; sporozoite surface protein 2 (SSP2); Provisional
    pfam15913
    Location:19 → 78
    Furin-like_2; Furin-like repeat, cysteine-rich
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Z132.1 GenPept UniProtKB/Swiss-Prot:Q9Z132

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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