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Luc7l2 LUC7-like 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 192196, updated on 9-May-2024

Summary

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Official Symbol
Luc7l2provided by MGI
Official Full Name
LUC7-like 2 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:2183260
See related
Ensembl:ENSMUSG00000029823 AllianceGenome:MGI:2183260
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CGI59; Cgi74; 4930471C18Rik
Summary
Predicted to enable enzyme binding activity and mRNA binding activity. Predicted to be involved in mRNA splice site selection. Located in nuclear speck. Orthologous to human LUC7L2 (LUC7 like 2, pre-mRNA splicing factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 17.0), bladder adult (RPKM 14.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
6 B1; 6 17.85 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (38522996..38586888)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (38551334..38609953)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr6:38484704-38484891 Neighboring gene nuclear encoded tRNA arginine 1 (anticodon CCT) Neighboring gene formation of mitochondrial complex V assembly factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E2782 Neighboring gene kinesin family member 11 pseudogene Neighboring gene killer cell lectin-like receptor subfamily G, member 2 Neighboring gene Clec2l Hedgehog-responsive enhancer Neighboring gene C-type lectin domain family 2, member L

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence for a direct role of the disease modifier SCNM1 in splicing. Howell VM, et al. Hum Mol Genet, 2007 Oct 15. PMID 17656373
  2. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
  3. The interactome of CLUH reveals its association to SPAG5 and its co-translational proximity to mitochondrial proteins. Hémono M, et al. BMC Biol, 2022 Jan 10. PMID 35012549, Free PMC Article
  4. Plasticity in the Glucagon Interactome Reveals Novel Proteins That Regulate Glucagon Secretion in α-TC1-6 Cells. Asadi F, et al. Front Endocrinol (Lausanne), 2018. PMID 30713523, Free PMC Article
  5. Huntingtin interacting proteins are genetic modifiers of neurodegeneration. Kaltenbach LS, et al. PLoS Genet, 2007 May 11. PMID 17500595, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in mRNA splice site recognition IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
putative RNA-binding protein Luc7-like 2
Names
CGI-74-like SR-rich

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170848.2 → NP_001164319.1  putative RNA-binding protein Luc7-like 2 isoform 2

    See identical proteins and their annotated locations for NP_001164319.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC124762, AC161147, AK134191
    UniProtKB/TrEMBL
    Q3UGK2, Q3UZ17
    Conserved Domains (1) summary
    pfam03194
    Location:5 → 241
    LUC7; LUC7 N_terminus

  2. NM_001170849.2 → NP_001164320.1  putative RNA-binding protein Luc7-like 2 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and 3' coding region, compared to variant 1. The resulting isoform (3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124762, AC161147, BC056383
    Consensus CDS
    CCDS51751.1
    UniProtKB/Swiss-Prot
    Q7TNC4
    Related
    ENSMUSP00000124010.2, ENSMUST00000161538.8
    Conserved Domains (2) summary
    COG5200
    Location:5 → 228
    LUC7; U1 snRNP component, mediates U1 snRNP association with cap-binding complex [RNA processing and modification]
    pfam03194
    Location:5 → 241
    LUC7; LUC7 N_terminus

  3. NM_001311099.2 → NP_001298028.1  putative RNA-binding protein Luc7-like 2 isoform 4

    See identical proteins and their annotated locations for NP_001298028.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) contains an alternate exon in the 5' region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 4, which has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC124762, AC161147
    Consensus CDS
    CCDS80524.1
    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Related
    ENSMUSP00000125111.2, ENSMUST00000161227.8
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  4. NM_001311100.2 → NP_001298029.1  putative RNA-binding protein Luc7-like 2 isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) contains an alternate exon in the 5' region, has a distinct 3' terminal exon and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 5, which has a shorter N-terminus and a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC124762, AC161147
    Consensus CDS
    CCDS80525.1
    UniProtKB/TrEMBL
    E9Q715
    Related
    ENSMUSP00000125394.2, ENSMUST00000163047.8
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  5. NM_001331222.1 → NP_001318151.1  putative RNA-binding protein Luc7-like 2 isoform 6

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains three alternate exons in the 5' region and initiates translation at an alternate start codon, and lacks an in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (6) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC124762, AC161147, AK046307, AK147889, CJ255376
    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  6. NM_001331223.1 → NP_001318152.1  putative RNA-binding protein Luc7-like 2 isoform 7

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' exons and initiates translation at a downstream start codon, and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (7) is shorter than isoform 1.
    Source sequence(s)
    AC124762, AC161147, AK140271, AK147889, AK153527, CJ255376
    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  7. NM_138680.3 → NP_619621.2  putative RNA-binding protein Luc7-like 2 isoform 1

    See identical proteins and their annotated locations for NP_619621.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC124762, AC161147
    Consensus CDS
    CCDS20015.1
    UniProtKB/Swiss-Prot
    Q7TNC4, Q99LM5, Q99PC3
    UniProtKB/TrEMBL
    Q3UGK2
    Related
    ENSMUSP00000055254.5, ENSMUST00000057692.11
    Conserved Domains (1) summary
    pfam03194
    Location:5 → 241
    LUC7; LUC7 N_terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    38522996..38586888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165939.1 → XP_036021832.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  2. XM_036165936.1 → XP_036021829.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  3. XM_036165942.1 → XP_036021835.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  4. XM_036165941.1 → XP_036021834.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  5. XM_036165946.1 → XP_036021839.1  putative RNA-binding protein Luc7-like 2 isoform X11

    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  6. XM_036165931.1 → XP_036021824.1  putative RNA-binding protein Luc7-like 2 isoform X6

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  7. XM_036165934.1 → XP_036021827.1  putative RNA-binding protein Luc7-like 2 isoform X8

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  8. XM_036165933.1 → XP_036021826.1  putative RNA-binding protein Luc7-like 2 isoform X7

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:14 → 238
    LUC7; LUC7 N_terminus

  9. XM_036165938.1 → XP_036021831.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  10. XM_036165932.1 → XP_036021825.1  putative RNA-binding protein Luc7-like 2 isoform X6

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  11. XM_036165935.1 → XP_036021828.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  12. XM_030255229.2 → XP_030111089.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  13. XM_030255226.2 → XP_030111086.1  putative RNA-binding protein Luc7-like 2 isoform X6

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  14. XM_036165940.1 → XP_036021833.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  15. XM_036165930.1 → XP_036021823.1  putative RNA-binding protein Luc7-like 2 isoform X3

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:61 → 275
    LUC7; LUC7 N_terminus

  16. XM_006505747.5 → XP_006505810.1  putative RNA-binding protein Luc7-like 2 isoform X4

    See identical proteins and their annotated locations for XP_006505810.1

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:41 → 245
    LUC7; LUC7 N_terminus

  17. XM_006505748.5 → XP_006505811.1  putative RNA-binding protein Luc7-like 2 isoform X5

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:41 → 245
    LUC7; LUC7 N_terminus

  18. XM_030255233.2 → XP_030111093.1  putative RNA-binding protein Luc7-like 2 isoform X11

    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  19. XM_036165928.1 → XP_036021821.1  putative RNA-binding protein Luc7-like 2 isoform X1

    Conserved Domains (1) summary
    pfam03194
    Location:5 → 312
    LUC7; LUC7 N_terminus

  20. XM_036165929.1 → XP_036021822.1  putative RNA-binding protein Luc7-like 2 isoform X2

    Conserved Domains (1) summary
    pfam03194
    Location:5 → 312
    LUC7; LUC7 N_terminus

  21. XM_036165945.1 → XP_036021838.1  putative RNA-binding protein Luc7-like 2 isoform X11

    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  22. XM_006505750.4 → XP_006505813.1  putative RNA-binding protein Luc7-like 2 isoform X6

    See identical proteins and their annotated locations for XP_006505813.1

    UniProtKB/TrEMBL
    Q3UGK2
    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  23. XM_030255232.2 → XP_030111092.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  24. XM_030255235.2 → XP_030111095.1  putative RNA-binding protein Luc7-like 2 isoform X11

    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  25. XM_036165943.1 → XP_036021836.1  putative RNA-binding protein Luc7-like 2 isoform X10

    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  26. XM_036165948.1 → XP_036021841.1  putative RNA-binding protein Luc7-like 2 isoform X13

    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  27. XM_030255236.2 → XP_030111096.1  putative RNA-binding protein Luc7-like 2 isoform X12

    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  28. XM_036165949.1 → XP_036021842.1  putative RNA-binding protein Luc7-like 2 isoform X13

    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  29. XM_030255237.2 → XP_030111097.1  putative RNA-binding protein Luc7-like 2 isoform X12

    Conserved Domains (1) summary
    pfam03194
    Location:26 → 240
    LUC7; LUC7 N_terminus

  30. XM_036165950.1 → XP_036021843.1  putative RNA-binding protein Luc7-like 2 isoform X14

    UniProtKB/TrEMBL
    E9Q715
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  31. XM_036165951.1 → XP_036021844.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  32. XM_036165937.1 → XP_036021830.1  putative RNA-binding protein Luc7-like 2 isoform X9

    UniProtKB/TrEMBL
    Q05CX5, Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus

  33. XM_036165944.1 → XP_036021837.1  putative RNA-binding protein Luc7-like 2 isoform X11

    UniProtKB/TrEMBL
    Q3U5L2
    Conserved Domains (1) summary
    pfam03194
    Location:1 → 188
    LUC7; LUC7 N_terminus
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TNC4.1 GenPept UniProtKB/Swiss-Prot:Q7TNC4

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